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Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum.
J Agric Food Chem. 2005 Sep 07; 53(18):7274-8.JA

Abstract

The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) was investigated by gas chromatography-mass spectrometry, and 21 compounds were identified. The major constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In the antiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibit proIL-1beta protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60 microg/mL, essential oil clearly inhibited proIL-1beta protein expression. Furthermore, a dose of 60 microg/mL of essential oil was effectively inhibitory for IL-1beta and IL-6 production but not for TNF-alpha, suggesting that essential oil was bioactive in antiinflammation in vitro. This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum.

Authors+Show Affiliations

Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan 717, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16131142

Citation

Chao, Louis Kuoping, et al. "Study On the Antiinflammatory Activity of Essential Oil From Leaves of Cinnamomum Osmophloeum." Journal of Agricultural and Food Chemistry, vol. 53, no. 18, 2005, pp. 7274-8.
Chao LK, Hua KF, Hsu HY, et al. Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. J Agric Food Chem. 2005;53(18):7274-8.
Chao, L. K., Hua, K. F., Hsu, H. Y., Cheng, S. S., Liu, J. Y., & Chang, S. T. (2005). Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. Journal of Agricultural and Food Chemistry, 53(18), 7274-8.
Chao LK, et al. Study On the Antiinflammatory Activity of Essential Oil From Leaves of Cinnamomum Osmophloeum. J Agric Food Chem. 2005 Sep 7;53(18):7274-8. PubMed PMID: 16131142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. AU - Chao,Louis Kuoping, AU - Hua,Kuo-Feng, AU - Hsu,Hsien-Yeh, AU - Cheng,Sen-Sung, AU - Liu,Ju-Yun, AU - Chang,Shang-Tzen, PY - 2005/9/1/pubmed PY - 2005/10/12/medline PY - 2005/9/1/entrez SP - 7274 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 53 IS - 18 N2 - The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) was investigated by gas chromatography-mass spectrometry, and 21 compounds were identified. The major constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In the antiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibit proIL-1beta protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60 microg/mL, essential oil clearly inhibited proIL-1beta protein expression. Furthermore, a dose of 60 microg/mL of essential oil was effectively inhibitory for IL-1beta and IL-6 production but not for TNF-alpha, suggesting that essential oil was bioactive in antiinflammation in vitro. This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16131142/Study_on_the_antiinflammatory_activity_of_essential_oil_from_leaves_of_Cinnamomum_osmophloeum_ DB - PRIME DP - Unbound Medicine ER -