Tags

Type your tag names separated by a space and hit enter

Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes.
J Am Chem Soc. 2005 Sep 07; 127(35):12230-1.JA

Abstract

A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions.

Authors+Show Affiliations

Zhang X
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Larock RC
No affiliation info available

MeSH

AlkynesAnisolesCyclizationHydrocarbons, HalogenatedModels, ChemicalMolecular StructureSpiro Compounds

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16131194

Citation

Zhang, Xiaoxia, and Richard C. Larock. "Synthesis of Spiro[4.5]trienones By Intramolecular Ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes." Journal of the American Chemical Society, vol. 127, no. 35, 2005, pp. 12230-1.
Zhang X, Larock RC. Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes. J Am Chem Soc. 2005;127(35):12230-1.
Zhang, X., & Larock, R. C. (2005). Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes. Journal of the American Chemical Society, 127(35), 12230-1.
Zhang X, Larock RC. Synthesis of Spiro[4.5]trienones By Intramolecular Ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes. J Am Chem Soc. 2005 Sep 7;127(35):12230-1. PubMed PMID: 16131194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes. AU - Zhang,Xiaoxia, AU - Larock,Richard C, PY - 2005/9/1/pubmed PY - 2005/12/15/medline PY - 2005/9/1/entrez SP - 12230 EP - 1 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 127 IS - 35 N2 - A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions. SN - 0002-7863 UR - https://www.unboundmedicine.com/medline/citation/16131194/Synthesis_of_spiro[4_5]trienones_by_intramolecular_ipso_halocyclization_of_4__p_methoxyaryl__1_alkynes_ DB - PRIME DP - Unbound Medicine ER -