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Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis.
Eur J Clin Nutr 2006; 60(1):41-7EJ

Abstract

OBJECTIVE

The aim of the study is to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors and, in particular, on some inflammatory biomarkers.

METHODS

A total of 48 subjects of both sexes who were nondrinkers or rare drinkers of moderate red wine were selected and randomly subdivided into two groups assigned to receive with a crossover design a Sicilian red wine (Nero d'Avola or Etna Torrepalino) during meals: Group A (n = 24), in whom the diet was supplemented for 4 weeks with 250 ml/day of red wine, followed by 4 weeks when they returned to their usual wine intake; and Group B (n = 24), in whom the usual wine intake was maintained for 4 weeks, followed by 4 weeks when the diet was supplemented with 250 ml/day of red wine. The following were values measured in all tests: blood glucose, total and HDL-cholesterol and triglycerides, LDL-cholesterol, LDL/HDL ratio, apolipoproteins A1 and B, Lp(a), plasma C-reactive protein, TGFbeta1, D-Dimer, Factor VII , PAl Ag, t-PA Ag, fibrinogen, oxidized LDL Ab, total plasma antioxidant capacity.

RESULTS

At the end of the red wine intake period, LDL/HDL, fibrinogen, factor VII, plasma C-reactive protein and oxidized LDL Ab were significantly decreased, while HDL-C, Apo A1,TGFbeta1, t-PA, PAI and total plasma antioxidant capacity were significantly increased.

CONCLUSIONS

Our results show a positive effect of two Sicilian red wines on many risk factors and on some inflammatory biomarkers, suggesting that a moderate consumption of red wine in the adult population is a positive component of the Mediterranean diet.

Authors+Show Affiliations

Institute of Clinical Medicine, University of Palermo, Palermo, Italy. ginoavellone@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16132058

Citation

Avellone, G, et al. "Effects of Moderate Sicilian Red Wine Consumption On Inflammatory Biomarkers of Atherosclerosis." European Journal of Clinical Nutrition, vol. 60, no. 1, 2006, pp. 41-7.
Avellone G, Di Garbo V, Campisi D, et al. Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. Eur J Clin Nutr. 2006;60(1):41-7.
Avellone, G., Di Garbo, V., Campisi, D., De Simone, R., Raneli, G., Scaglione, R., & Licata, G. (2006). Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. European Journal of Clinical Nutrition, 60(1), pp. 41-7.
Avellone G, et al. Effects of Moderate Sicilian Red Wine Consumption On Inflammatory Biomarkers of Atherosclerosis. Eur J Clin Nutr. 2006;60(1):41-7. PubMed PMID: 16132058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. AU - Avellone,G, AU - Di Garbo,V, AU - Campisi,D, AU - De Simone,R, AU - Raneli,G, AU - Scaglione,R, AU - Licata,G, PY - 2005/9/1/pubmed PY - 2006/4/21/medline PY - 2005/9/1/entrez SP - 41 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 1 N2 - OBJECTIVE: The aim of the study is to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors and, in particular, on some inflammatory biomarkers. METHODS: A total of 48 subjects of both sexes who were nondrinkers or rare drinkers of moderate red wine were selected and randomly subdivided into two groups assigned to receive with a crossover design a Sicilian red wine (Nero d'Avola or Etna Torrepalino) during meals: Group A (n = 24), in whom the diet was supplemented for 4 weeks with 250 ml/day of red wine, followed by 4 weeks when they returned to their usual wine intake; and Group B (n = 24), in whom the usual wine intake was maintained for 4 weeks, followed by 4 weeks when the diet was supplemented with 250 ml/day of red wine. The following were values measured in all tests: blood glucose, total and HDL-cholesterol and triglycerides, LDL-cholesterol, LDL/HDL ratio, apolipoproteins A1 and B, Lp(a), plasma C-reactive protein, TGFbeta1, D-Dimer, Factor VII , PAl Ag, t-PA Ag, fibrinogen, oxidized LDL Ab, total plasma antioxidant capacity. RESULTS: At the end of the red wine intake period, LDL/HDL, fibrinogen, factor VII, plasma C-reactive protein and oxidized LDL Ab were significantly decreased, while HDL-C, Apo A1,TGFbeta1, t-PA, PAI and total plasma antioxidant capacity were significantly increased. CONCLUSIONS: Our results show a positive effect of two Sicilian red wines on many risk factors and on some inflammatory biomarkers, suggesting that a moderate consumption of red wine in the adult population is a positive component of the Mediterranean diet. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16132058/Effects_of_moderate_Sicilian_red_wine_consumption_on_inflammatory_biomarkers_of_atherosclerosis_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602265 DB - PRIME DP - Unbound Medicine ER -