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Body mass index, body height, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study.
Cancer Causes Control. 2005 Sep; 16(7):839-50.CC

Abstract

OBJECTIVE

To investigate the association of body mass index (BMI) or body height with colorectal cancer incidence in a population-based prospective study.

METHODS

We identified 986 (626 men and 360 women) newly diagnosed cases of colorectal cancer during the 9.4-year follow-up of a cohort consisting of 102,949 (49,158 male and 53,791 female) middle-aged and elderly Japanese.

RESULTS

Lower BMI groups (lower than 23) were not associated with colorectal cancer compared with the 23-24.9 BMI group. Any categories of 25-26.9, 27-29.9, or 30 or more BMI were associated with an increased risk of colorectal cancer compared with the lower than 25 BMI (RR, 1.2 for 25-26.9, 1.4 for 27-29.9, and 1.5 for 30 or more; p for trend, 0.004) in men. These associations were more evident only in invasive-type cancer analysis. BMI was not associated with the risk of colorectal cancer in women. No significant association with height was obtained for either men or women.

CONCLUSIONS

The association of BMI with colorectal cancer was confirmed in a Japanese population as well as Western populations. Only invasive-cancer analysis suggested that BMI was important for tumor growth and proliferation. Approximately 6.7% of colorectal cancer was attributable to a BMI of 25 or higher in middle-aged and elderly Japanese men.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. teotani@gan2.res.ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16132794

Citation

Otani, Tetsuya, et al. "Body Mass Index, Body Height, and Subsequent Risk of Colorectal Cancer in Middle-aged and Elderly Japanese Men and Women: Japan Public Health Center-based Prospective Study." Cancer Causes & Control : CCC, vol. 16, no. 7, 2005, pp. 839-50.
Otani T, Iwasaki M, Inoue M, et al. Body mass index, body height, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study. Cancer Causes Control. 2005;16(7):839-50.
Otani, T., Iwasaki, M., & Inoue, M. (2005). Body mass index, body height, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study. Cancer Causes & Control : CCC, 16(7), 839-50.
Otani T, et al. Body Mass Index, Body Height, and Subsequent Risk of Colorectal Cancer in Middle-aged and Elderly Japanese Men and Women: Japan Public Health Center-based Prospective Study. Cancer Causes Control. 2005;16(7):839-50. PubMed PMID: 16132794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, body height, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study. AU - Otani,Tetsuya, AU - Iwasaki,Motoki, AU - Inoue,Manami, AU - ,, PY - 2005/9/1/pubmed PY - 2006/7/11/medline PY - 2005/9/1/entrez SP - 839 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 7 N2 - OBJECTIVE: To investigate the association of body mass index (BMI) or body height with colorectal cancer incidence in a population-based prospective study. METHODS: We identified 986 (626 men and 360 women) newly diagnosed cases of colorectal cancer during the 9.4-year follow-up of a cohort consisting of 102,949 (49,158 male and 53,791 female) middle-aged and elderly Japanese. RESULTS: Lower BMI groups (lower than 23) were not associated with colorectal cancer compared with the 23-24.9 BMI group. Any categories of 25-26.9, 27-29.9, or 30 or more BMI were associated with an increased risk of colorectal cancer compared with the lower than 25 BMI (RR, 1.2 for 25-26.9, 1.4 for 27-29.9, and 1.5 for 30 or more; p for trend, 0.004) in men. These associations were more evident only in invasive-type cancer analysis. BMI was not associated with the risk of colorectal cancer in women. No significant association with height was obtained for either men or women. CONCLUSIONS: The association of BMI with colorectal cancer was confirmed in a Japanese population as well as Western populations. Only invasive-cancer analysis suggested that BMI was important for tumor growth and proliferation. Approximately 6.7% of colorectal cancer was attributable to a BMI of 25 or higher in middle-aged and elderly Japanese men. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16132794/Body_mass_index_body_height_and_subsequent_risk_of_colorectal_cancer_in_middle_aged_and_elderly_Japanese_men_and_women:_Japan_public_health_center_based_prospective_study_ L2 - https://doi.org/10.1007/s10552-005-4573-z DB - PRIME DP - Unbound Medicine ER -