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Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States).
Cancer Causes Control. 2005 Sep; 16(7):877-91.CC

Abstract

Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. The authors sought to replicate these findings and investigate other aspects of diet. Mothers of 315 cases under age six at diagnosis and 315 controls were interviewed about their pregnancy diet. The authors observed modest, inverse associations for fruits/juices (odds ratio (OR) for highest compared to lowest category = 0.6, 95% confidence interval (CI): 0.3, 1.1) and vitamin C (OR = 0.6, 95% CI: 0.4, 1.1). In contrast to the previous study, folate and vegetables showed no association. As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors. An inverse association with non-fresh peaches and similar fruits (OR = 0.5, 95% CI: 0.3, 0.8) and a positive association with non-chocolate candy (OR = 1.7, 95% CI: 1.0, 3.0) replicated previous findings. French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research.

Authors+Show Affiliations

Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. bunin@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16132798

Citation

Bunin, Greta R., et al. "Maternal Diet During Pregnancy and Its Association With Medulloblastoma in Children: a Children's Oncology Group Study (United States)." Cancer Causes & Control : CCC, vol. 16, no. 7, 2005, pp. 877-91.
Bunin GR, Kushi LH, Gallagher PR, et al. Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). Cancer Causes Control. 2005;16(7):877-91.
Bunin, G. R., Kushi, L. H., Gallagher, P. R., Rorke-Adams, L. B., McBride, M. L., & Cnaan, A. (2005). Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). Cancer Causes & Control : CCC, 16(7), 877-91.
Bunin GR, et al. Maternal Diet During Pregnancy and Its Association With Medulloblastoma in Children: a Children's Oncology Group Study (United States). Cancer Causes Control. 2005;16(7):877-91. PubMed PMID: 16132798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). AU - Bunin,Greta R, AU - Kushi,Lawrence H, AU - Gallagher,Paul R, AU - Rorke-Adams,Lucy B, AU - McBride,Mary L, AU - Cnaan,Avital, PY - 2005/01/03/received PY - 2005/03/03/accepted PY - 2005/9/1/pubmed PY - 2006/7/11/medline PY - 2005/9/1/entrez SP - 877 EP - 91 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 7 N2 - Fruit, vegetables, vitamin C, and folate during pregnancy have been suggested as protective factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. The authors sought to replicate these findings and investigate other aspects of diet. Mothers of 315 cases under age six at diagnosis and 315 controls were interviewed about their pregnancy diet. The authors observed modest, inverse associations for fruits/juices (odds ratio (OR) for highest compared to lowest category = 0.6, 95% confidence interval (CI): 0.3, 1.1) and vitamin C (OR = 0.6, 95% CI: 0.4, 1.1). In contrast to the previous study, folate and vegetables showed no association. As hypothesized, cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors. An inverse association with non-fresh peaches and similar fruits (OR = 0.5, 95% CI: 0.3, 0.8) and a positive association with non-chocolate candy (OR = 1.7, 95% CI: 1.0, 3.0) replicated previous findings. French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16132798/Maternal_diet_during_pregnancy_and_its_association_with_medulloblastoma_in_children:_a_children's_oncology_group_study__United_States__ L2 - https://doi.org/10.1007/s10552-005-3144-7 DB - PRIME DP - Unbound Medicine ER -