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The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels.
Am J Community Psychol. 2005 Sep; 36(1-2):159-75.AJ

Abstract

BACKGROUND

Women who experience intimate partner violence (IPV) report greater stress and negative health consequences than nonabused women. Although an association between psychological stress and altered immune function has been shown, IPV studies have not investigated this relationship.

OBJECTIVE

This study explored the association of IPV with mental health symptoms and an immune marker to determine if posttraumatic stress disorder (PTSD) symptoms mediate the effect of IPV on pro-inflammatory (IFN-gamma) cytokine levels.

METHODS

A cross-sectional, comparative design was used to compare 62 women with IPV and 39 nonabused women.

RESULTS

Mean IFN-gamma values were higher in abused women and in women with current PTSD symptoms. There were no significant relationships with potential confounding variables that could provide an alternative explanation for the increase in production of proinflammatory cytokines.

CONCLUSIONS

PTSD symptoms mediate the association between IPV and IFN-gamma levels and may partially explain the association of mental health symptoms with physical health sequelae in IPV.

Authors+Show Affiliations

Johns Hopkins University School of Nursing, 525 N. Wolfe Street, Room 442, Baltimore, Maryland 21205, USA. awoods1@son.jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16134052

Citation

Woods, Anne B., et al. "The Mediation Effect of Posttraumatic Stress Disorder Symptoms On the Relationship of Intimate Partner Violence and IFN-gamma Levels." American Journal of Community Psychology, vol. 36, no. 1-2, 2005, pp. 159-75.
Woods AB, Page GG, O'Campo P, et al. The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels. Am J Community Psychol. 2005;36(1-2):159-75.
Woods, A. B., Page, G. G., O'Campo, P., Pugh, L. C., Ford, D., & Campbell, J. C. (2005). The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels. American Journal of Community Psychology, 36(1-2), 159-75.
Woods AB, et al. The Mediation Effect of Posttraumatic Stress Disorder Symptoms On the Relationship of Intimate Partner Violence and IFN-gamma Levels. Am J Community Psychol. 2005;36(1-2):159-75. PubMed PMID: 16134052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels. AU - Woods,Anne B, AU - Page,Gayle G, AU - O'Campo,Patricia, AU - Pugh,Linda C, AU - Ford,Daniel, AU - Campbell,Jacquelyn C, PY - 2005/9/1/pubmed PY - 2006/2/16/medline PY - 2005/9/1/entrez SP - 159 EP - 75 JF - American journal of community psychology JO - Am J Community Psychol VL - 36 IS - 1-2 N2 - BACKGROUND: Women who experience intimate partner violence (IPV) report greater stress and negative health consequences than nonabused women. Although an association between psychological stress and altered immune function has been shown, IPV studies have not investigated this relationship. OBJECTIVE: This study explored the association of IPV with mental health symptoms and an immune marker to determine if posttraumatic stress disorder (PTSD) symptoms mediate the effect of IPV on pro-inflammatory (IFN-gamma) cytokine levels. METHODS: A cross-sectional, comparative design was used to compare 62 women with IPV and 39 nonabused women. RESULTS: Mean IFN-gamma values were higher in abused women and in women with current PTSD symptoms. There were no significant relationships with potential confounding variables that could provide an alternative explanation for the increase in production of proinflammatory cytokines. CONCLUSIONS: PTSD symptoms mediate the association between IPV and IFN-gamma levels and may partially explain the association of mental health symptoms with physical health sequelae in IPV. SN - 0091-0562 UR - https://www.unboundmedicine.com/medline/citation/16134052/The_mediation_effect_of_posttraumatic_stress_disorder_symptoms_on_the_relationship_of_intimate_partner_violence_and_IFN_gamma_levels_ L2 - https://www.springerlink.com/10.1007/s10464-005-6240-7 DB - PRIME DP - Unbound Medicine ER -