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Does leptin play a cytokine-like role within the airways of COPD patients?
Eur Respir J. 2005 Sep; 26(3):398-405.ER

Abstract

The leptin-leptin receptor system might be up-regulated in the airways of chronic obstructive pulmonary disease (COPD). In bronchial biopsies obtained from normal subjects and smokers, with and without COPD, the present study examined leptin and leptin-receptor expression and their co-localisation in airway and inflammatory cells. Combining immunohistochemistry with terminal deoxynucleotidyl transferase dUTP nick end-labelling techniques, apoptosis in airway and inflammatory cells and in leptin and leptin-receptor expressing cells was investigated. In the epithelial cells both leptin and leptin-receptor expression was higher in normal subjects than in smokers and COPD subjects. By contrast, in the sub-mucosa, leptin was over-expressed in COPD when compared with normal subjects and smokers. Leptin and its receptor were co-localised, mainly with activated T cells (CD45R0) and CD8+ T lymphocytes. In smokers, apoptosis was found in some inflammatory cells, whereas in COPD inflammatory cells, leptin and leptin-receptor positive cells were not apoptotic. Leptin expression was related to COPD severity and assessed using the Global initiative for Chronic Obstructive Lung Disease classification. In conclusion, the present study shows an increased leptin expression in bronchial mucosa of chronic obstructive pulmonary disease patients, associated with airway inflammation and airflow obstruction.

Authors+Show Affiliations

Istituto di Biomedicina e Immunologia Molecolare-Consiglio Nazionale delle Ricerche, Via Ugo La Malfa, 153-90146 Palermo, Italy. andreina@neomedia.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16135719

Citation

Bruno, A, et al. "Does Leptin Play a Cytokine-like Role Within the Airways of COPD Patients?" The European Respiratory Journal, vol. 26, no. 3, 2005, pp. 398-405.
Bruno A, Chanez P, Chiappara G, et al. Does leptin play a cytokine-like role within the airways of COPD patients? Eur Respir J. 2005;26(3):398-405.
Bruno, A., Chanez, P., Chiappara, G., Siena, L., Giammanco, S., Gjomarkaj, M., Bonsignore, G., Bousquet, J., & Vignola, A. M. (2005). Does leptin play a cytokine-like role within the airways of COPD patients? The European Respiratory Journal, 26(3), 398-405.
Bruno A, et al. Does Leptin Play a Cytokine-like Role Within the Airways of COPD Patients. Eur Respir J. 2005;26(3):398-405. PubMed PMID: 16135719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does leptin play a cytokine-like role within the airways of COPD patients? AU - Bruno,A, AU - Chanez,P, AU - Chiappara,G, AU - Siena,L, AU - Giammanco,S, AU - Gjomarkaj,M, AU - Bonsignore,G, AU - Bousquet,J, AU - Vignola,A M, PY - 2005/9/2/pubmed PY - 2005/10/26/medline PY - 2005/9/2/entrez SP - 398 EP - 405 JF - The European respiratory journal JO - Eur Respir J VL - 26 IS - 3 N2 - The leptin-leptin receptor system might be up-regulated in the airways of chronic obstructive pulmonary disease (COPD). In bronchial biopsies obtained from normal subjects and smokers, with and without COPD, the present study examined leptin and leptin-receptor expression and their co-localisation in airway and inflammatory cells. Combining immunohistochemistry with terminal deoxynucleotidyl transferase dUTP nick end-labelling techniques, apoptosis in airway and inflammatory cells and in leptin and leptin-receptor expressing cells was investigated. In the epithelial cells both leptin and leptin-receptor expression was higher in normal subjects than in smokers and COPD subjects. By contrast, in the sub-mucosa, leptin was over-expressed in COPD when compared with normal subjects and smokers. Leptin and its receptor were co-localised, mainly with activated T cells (CD45R0) and CD8+ T lymphocytes. In smokers, apoptosis was found in some inflammatory cells, whereas in COPD inflammatory cells, leptin and leptin-receptor positive cells were not apoptotic. Leptin expression was related to COPD severity and assessed using the Global initiative for Chronic Obstructive Lung Disease classification. In conclusion, the present study shows an increased leptin expression in bronchial mucosa of chronic obstructive pulmonary disease patients, associated with airway inflammation and airflow obstruction. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/16135719/Does_leptin_play_a_cytokine_like_role_within_the_airways_of_COPD_patients L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=16135719 DB - PRIME DP - Unbound Medicine ER -