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Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC).
Br J Cancer 2005; 93(5):582-9BJ

Abstract

We examined prospectively the association between weight change during adulthood and breast cancer risk, using data on 1358 incident cases that developed during 5.8 years of follow-up among 40,429 premenopausal and 57,923 postmenopausal women from six European countries, taking part in the European prospective investigation into cancer and nutrition study. Multivariate Cox regression models were used to calculate hazard ratios according to weight change (kg), defined as the weight difference between age at enrollment and age 20 adjusted for other risk factors. Changes in weight were not associated with premenopausal breast cancer risk. In postmenopausal women, weight gain was positively associated with breast cancer risk only among noncurrent hormone replacement therapy (HRT) users (P-trend < or = 0.0002). Compared to women with a stable weight (+/-2 kg), the relative risk for women who gained 15-20 kg was 1.50 (95% confidence interval (CI) 1.06-2.13). The pooled RR per weight gain increment of 5 kg was 1.08 (95% CI 1.04-1.12). Weight gain was not associated with breast cancer risk in current HRT users, although, overall, these women experienced a much higher risk of breast cancer compared with nonusers. Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany. Lahmann@mail.dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16136032

Citation

Lahmann, P H., et al. "Long-term Weight Change and Breast Cancer Risk: the European Prospective Investigation Into Cancer and Nutrition (EPIC)." British Journal of Cancer, vol. 93, no. 5, 2005, pp. 582-9.
Lahmann PH, Schulz M, Hoffmann K, et al. Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). Br J Cancer. 2005;93(5):582-9.
Lahmann, P. H., Schulz, M., Hoffmann, K., Boeing, H., Tjønneland, A., Olsen, A., ... Riboli, E. (2005). Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). British Journal of Cancer, 93(5), pp. 582-9.
Lahmann PH, et al. Long-term Weight Change and Breast Cancer Risk: the European Prospective Investigation Into Cancer and Nutrition (EPIC). Br J Cancer. 2005 Sep 5;93(5):582-9. PubMed PMID: 16136032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). AU - Lahmann,P H, AU - Schulz,M, AU - Hoffmann,K, AU - Boeing,H, AU - Tjønneland,A, AU - Olsen,A, AU - Overvad,K, AU - Key,T J, AU - Allen,N E, AU - Khaw,K-T, AU - Bingham,S, AU - Berglund,G, AU - Wirfält,E, AU - Berrino,F, AU - Krogh,V, AU - Trichopoulou,A, AU - Lagiou,P, AU - Trichopoulos,D, AU - Kaaks,R, AU - Riboli,E, PY - 2005/9/2/pubmed PY - 2005/10/19/medline PY - 2005/9/2/entrez SP - 582 EP - 9 JF - British journal of cancer JO - Br. J. Cancer VL - 93 IS - 5 N2 - We examined prospectively the association between weight change during adulthood and breast cancer risk, using data on 1358 incident cases that developed during 5.8 years of follow-up among 40,429 premenopausal and 57,923 postmenopausal women from six European countries, taking part in the European prospective investigation into cancer and nutrition study. Multivariate Cox regression models were used to calculate hazard ratios according to weight change (kg), defined as the weight difference between age at enrollment and age 20 adjusted for other risk factors. Changes in weight were not associated with premenopausal breast cancer risk. In postmenopausal women, weight gain was positively associated with breast cancer risk only among noncurrent hormone replacement therapy (HRT) users (P-trend < or = 0.0002). Compared to women with a stable weight (+/-2 kg), the relative risk for women who gained 15-20 kg was 1.50 (95% confidence interval (CI) 1.06-2.13). The pooled RR per weight gain increment of 5 kg was 1.08 (95% CI 1.04-1.12). Weight gain was not associated with breast cancer risk in current HRT users, although, overall, these women experienced a much higher risk of breast cancer compared with nonusers. Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/16136032/Long_term_weight_change_and_breast_cancer_risk:_the_European_prospective_investigation_into_cancer_and_nutrition__EPIC__ L2 - http://dx.doi.org/10.1038/sj.bjc.6602763 DB - PRIME DP - Unbound Medicine ER -