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Gynecologic Cancers in Lynch Syndrome/HNPCC.

Abstract

Recent studies have estimated that the lifetime risk of endometrial cancer in women with Lynch syndrome/hereditary non-polyposis colorectal cancer syndrome (Lynch/HNPCC) is 40-60%. This risk equals or exceeds their risk for colon cancer. While much research has been done to define the natural history and molecular features of Lynch/HNPCC associated colon cancer, there has been considerably less research defining Lynch/HNPCC associated endometrial cancer. This article will review current information regarding the clinico-pathologic features of Lynch/HNPCC associated endometrial cancer. In addition, current consensus guidelines for endometrial cancer screening and prevention for women with Lynch/HNPCC will be discussed. Given the increased risk of multiple cancers, changing the name of this syndrome from hereditary non-polyposis colorectal cancer syndrome to Lynch Syndrome may benefit both patients and clinicians. Clinicians caring for women with Lynch/HNPCC may stress colon cancer screening and prevention without reviewing endometrial cancer risks and symptoms or screening and prevention options. Perhaps more importantly, women with Lynch/HNPCC may focus on colon cancer risks and lack understanding of endometrial cancer risks. With increasing evidence that women with Lynch/HNPCC have significant risks for both colon and endometrial cancers, we believe a multi-disciplinary approach to the management of these individuals is crucial.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Gynecologic Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. khlu@mdanderson.org

    Source

    Familial cancer 4:3 2005 pg 249-54

    MeSH

    Colorectal Neoplasms, Hereditary Nonpolyposis
    Endometrial Neoplasms
    Female
    Humans
    Ovarian Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    16136386

    Citation

    Lu, Karen H., and Russell R. Broaddus. "Gynecologic Cancers in Lynch Syndrome/HNPCC." Familial Cancer, vol. 4, no. 3, 2005, pp. 249-54.
    Lu KH, Broaddus RR. Gynecologic Cancers in Lynch Syndrome/HNPCC. Fam Cancer. 2005;4(3):249-54.
    Lu, K. H., & Broaddus, R. R. (2005). Gynecologic Cancers in Lynch Syndrome/HNPCC. Familial Cancer, 4(3), pp. 249-54.
    Lu KH, Broaddus RR. Gynecologic Cancers in Lynch Syndrome/HNPCC. Fam Cancer. 2005;4(3):249-54. PubMed PMID: 16136386.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gynecologic Cancers in Lynch Syndrome/HNPCC. AU - Lu,Karen H, AU - Broaddus,Russell R, PY - 2004/09/08/received PY - 2005/02/07/accepted PY - 2005/9/2/pubmed PY - 2005/12/13/medline PY - 2005/9/2/entrez SP - 249 EP - 54 JF - Familial cancer JO - Fam. Cancer VL - 4 IS - 3 N2 - Recent studies have estimated that the lifetime risk of endometrial cancer in women with Lynch syndrome/hereditary non-polyposis colorectal cancer syndrome (Lynch/HNPCC) is 40-60%. This risk equals or exceeds their risk for colon cancer. While much research has been done to define the natural history and molecular features of Lynch/HNPCC associated colon cancer, there has been considerably less research defining Lynch/HNPCC associated endometrial cancer. This article will review current information regarding the clinico-pathologic features of Lynch/HNPCC associated endometrial cancer. In addition, current consensus guidelines for endometrial cancer screening and prevention for women with Lynch/HNPCC will be discussed. Given the increased risk of multiple cancers, changing the name of this syndrome from hereditary non-polyposis colorectal cancer syndrome to Lynch Syndrome may benefit both patients and clinicians. Clinicians caring for women with Lynch/HNPCC may stress colon cancer screening and prevention without reviewing endometrial cancer risks and symptoms or screening and prevention options. Perhaps more importantly, women with Lynch/HNPCC may focus on colon cancer risks and lack understanding of endometrial cancer risks. With increasing evidence that women with Lynch/HNPCC have significant risks for both colon and endometrial cancers, we believe a multi-disciplinary approach to the management of these individuals is crucial. SN - 1389-9600 UR - https://www.unboundmedicine.com/medline/citation/16136386/Gynecologic_Cancers_in_Lynch_Syndrome/HNPCC_ L2 - https://doi.org/10.1007/s10689-005-1838-3 DB - PRIME DP - Unbound Medicine ER -