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Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules.
J Pharm Sci. 2005 Oct; 94(10):2314-26.JP

Abstract

Effect of variation in the ambient moisture levels on the compaction behavior of a 10% acetaminophen (APAP) powder blend in microcrystalline cellulose (MCC) powder was studied by comparing the physical and mechanical properties of ribbons prepared by roller compaction with those of simulated ribbons, i.e., tablets prepared under uni-axial compression. Relative density, moisture content, tensile strength, and Young's modulus were used as key compact properties for comparison. Moisture was found to facilitate the particle rearrangement of both, the APAP and the MCC particles, as well as the deformation of the MCC particles. The tensile strength of the simulated ribbons also showed an increase with increasing moisture content. An interesting observation was that the tensile strength of the roller compacted samples first increased and then decreased with increasing moisture content. Variation in the ambient moisture during roller compaction was also found to influence the characteristics of tablets produced from the granules obtained post-milling the ribbons. A method to study this influence is also reported.

Authors+Show Affiliations

Gupta A
Department of Industrial and Physical Pharmacy, Purdue University School of Pharmacy, West Lafayette, Indiana 47907-2091, USA.
Peck GE
No affiliation info available
Miller RW
No affiliation info available
Morris KR
No affiliation info available

MeSH

AcetaminophenCelluloseDrug CompoundingExcipientsHumidityParticle SizePorosityPowdersSolubilityTabletsTensile StrengthWater

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16136545

Citation

Gupta, Abhay, et al. "Effect of the Variation in the Ambient Moisture On the Compaction Behavior of Powder Undergoing Roller-compaction and On the Characteristics of Tablets Produced From the Post-milled Granules." Journal of Pharmaceutical Sciences, vol. 94, no. 10, 2005, pp. 2314-26.
Gupta A, Peck GE, Miller RW, et al. Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules. J Pharm Sci. 2005;94(10):2314-26.
Gupta, A., Peck, G. E., Miller, R. W., & Morris, K. R. (2005). Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules. Journal of Pharmaceutical Sciences, 94(10), 2314-26.
Gupta A, et al. Effect of the Variation in the Ambient Moisture On the Compaction Behavior of Powder Undergoing Roller-compaction and On the Characteristics of Tablets Produced From the Post-milled Granules. J Pharm Sci. 2005;94(10):2314-26. PubMed PMID: 16136545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules. AU - Gupta,Abhay, AU - Peck,Garnet E, AU - Miller,Ronald W, AU - Morris,Kenneth R, PY - 2005/9/2/pubmed PY - 2006/2/1/medline PY - 2005/9/2/entrez SP - 2314 EP - 26 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 94 IS - 10 N2 - Effect of variation in the ambient moisture levels on the compaction behavior of a 10% acetaminophen (APAP) powder blend in microcrystalline cellulose (MCC) powder was studied by comparing the physical and mechanical properties of ribbons prepared by roller compaction with those of simulated ribbons, i.e., tablets prepared under uni-axial compression. Relative density, moisture content, tensile strength, and Young's modulus were used as key compact properties for comparison. Moisture was found to facilitate the particle rearrangement of both, the APAP and the MCC particles, as well as the deformation of the MCC particles. The tensile strength of the simulated ribbons also showed an increase with increasing moisture content. An interesting observation was that the tensile strength of the roller compacted samples first increased and then decreased with increasing moisture content. Variation in the ambient moisture during roller compaction was also found to influence the characteristics of tablets produced from the granules obtained post-milling the ribbons. A method to study this influence is also reported. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/16136545/Effect_of_the_variation_in_the_ambient_moisture_on_the_compaction_behavior_of_powder_undergoing_roller_compaction_and_on_the_characteristics_of_tablets_produced_from_the_post_milled_granules_ DB - PRIME DP - Unbound Medicine ER -