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Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding.
Dev Psychobiol 2005; 47(2):145-57DP

Abstract

Previous research in our laboratory found that repeated exposure of adolescent rats to 3,4-methylenedioxymethamphetamine (MDMA) impaired working memory and reduced anxiety. The present experiment extended these findings by investigating the physiological, behavioral, and neurotoxic effects of a modified MDMA treatment regimen. Male Sprague-Dawley rats received 5 mg/kg of MDMA hourly for a period of 4 hr on every fifth day from postnatal day 35-60. Acute effects of the MDMA treatment included hypothermia, serotonin syndrome behavior, and ejaculation. Body weight gain was attenuated by repeated drug administration. The animals completed anxiety and working memory tests beginning 4 days after the final MDMA dose. MDMA altered habituation to the open-field, increased locomotor activity in the elevated plus-maze, decreased attention in the novel object-recognition test, and reduced serotonin transporter binding in the neocortex. These results indicate that repeated exposure to a relatively moderate MDMA dose during adolescence produces later changes in behavior and neurochemistry.

Authors+Show Affiliations

Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16136551

Citation

Piper, Brian J., et al. "Repeated MDMA ("Ecstasy") Exposure in Adolescent Male Rats Alters Temperature Regulation, Spontaneous Motor Activity, Attention, and Serotonin Transporter Binding." Developmental Psychobiology, vol. 47, no. 2, 2005, pp. 145-57.
Piper BJ, Fraiman JB, Meyer JS. Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. Dev Psychobiol. 2005;47(2):145-57.
Piper, B. J., Fraiman, J. B., & Meyer, J. S. (2005). Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. Developmental Psychobiology, 47(2), pp. 145-57.
Piper BJ, Fraiman JB, Meyer JS. Repeated MDMA ("Ecstasy") Exposure in Adolescent Male Rats Alters Temperature Regulation, Spontaneous Motor Activity, Attention, and Serotonin Transporter Binding. Dev Psychobiol. 2005;47(2):145-57. PubMed PMID: 16136551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. AU - Piper,Brian J, AU - Fraiman,Joseph B, AU - Meyer,Jerrold S, PY - 2005/9/2/pubmed PY - 2006/2/14/medline PY - 2005/9/2/entrez SP - 145 EP - 57 JF - Developmental psychobiology JO - Dev Psychobiol VL - 47 IS - 2 N2 - Previous research in our laboratory found that repeated exposure of adolescent rats to 3,4-methylenedioxymethamphetamine (MDMA) impaired working memory and reduced anxiety. The present experiment extended these findings by investigating the physiological, behavioral, and neurotoxic effects of a modified MDMA treatment regimen. Male Sprague-Dawley rats received 5 mg/kg of MDMA hourly for a period of 4 hr on every fifth day from postnatal day 35-60. Acute effects of the MDMA treatment included hypothermia, serotonin syndrome behavior, and ejaculation. Body weight gain was attenuated by repeated drug administration. The animals completed anxiety and working memory tests beginning 4 days after the final MDMA dose. MDMA altered habituation to the open-field, increased locomotor activity in the elevated plus-maze, decreased attention in the novel object-recognition test, and reduced serotonin transporter binding in the neocortex. These results indicate that repeated exposure to a relatively moderate MDMA dose during adolescence produces later changes in behavior and neurochemistry. SN - 0012-1630 UR - https://www.unboundmedicine.com/medline/citation/16136551/Repeated_MDMA__"Ecstasy"__exposure_in_adolescent_male_rats_alters_temperature_regulation_spontaneous_motor_activity_attention_and_serotonin_transporter_binding_ L2 - https://doi.org/10.1002/dev.20085 DB - PRIME DP - Unbound Medicine ER -