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[Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis].
Zhonghua Fu Chan Ke Za Zhi. 2001 Dec; 36(12):727-30.ZF

Abstract

OBJECTIVE

To detect the expression of vascular endothelial growth factor (VEGF) and thrombospondin (TSP)-1 mRNA in the ectopic and eutopic endometrium of patients with endometriosis.

METHODS

Thirty-two specimens of ovarian endometrioma, 12 red peritoneal lesion, 8 uterosacral ligament nodule, and 30 matched eutopic endometrium were biopsied from 38 patients with endometriosis, another 25 specimens of endometrium were biopsied from women without endometriosis. Reverse transcript-polymerase chain reaction (RT-PCR) and Northern Blot analysis were utilized to examine VEGF mRNA and TSP-1 mRNA expression and their relative levels in the above endometrium.

RESULTS

Among endometriotic lesions, red peritoneal lesion expressed higher level of VEGF and lower level of TSP-1, whereas ovarian endometrioma expressed lower level VEGF and higher level of TSP-1. Eutopic endometrium of women with endometriosis had higer level of VEGF expression and lower level of TSP-1 expression than women without endometriosis.

CONCLUSIONS

The expression of VEGF and TSP-1 in endometriotic lesion appears to be associated with its neovalscualization extent. The imbalance in expression of VEGF and TSP-1 in endometrium might be related to the development of endometriosis and its biological behavior.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16136892

Citation

Tan, X, et al. "[Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in the Ectopic and Eutopic Endometrium of Women With Endometriosis]." Zhonghua Fu Chan Ke Za Zhi, vol. 36, no. 12, 2001, pp. 727-30.
Tan X, Lang J, Liu D. [Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2001;36(12):727-30.
Tan, X., Lang, J., & Liu, D. (2001). [Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis]. Zhonghua Fu Chan Ke Za Zhi, 36(12), 727-30.
Tan X, Lang J, Liu D. [Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in the Ectopic and Eutopic Endometrium of Women With Endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2001;36(12):727-30. PubMed PMID: 16136892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis]. AU - Tan,X, AU - Lang,J, AU - Liu,D, PY - 2005/9/3/pubmed PY - 2010/5/15/medline PY - 2005/9/3/entrez SP - 727 EP - 30 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 36 IS - 12 N2 - OBJECTIVE: To detect the expression of vascular endothelial growth factor (VEGF) and thrombospondin (TSP)-1 mRNA in the ectopic and eutopic endometrium of patients with endometriosis. METHODS: Thirty-two specimens of ovarian endometrioma, 12 red peritoneal lesion, 8 uterosacral ligament nodule, and 30 matched eutopic endometrium were biopsied from 38 patients with endometriosis, another 25 specimens of endometrium were biopsied from women without endometriosis. Reverse transcript-polymerase chain reaction (RT-PCR) and Northern Blot analysis were utilized to examine VEGF mRNA and TSP-1 mRNA expression and their relative levels in the above endometrium. RESULTS: Among endometriotic lesions, red peritoneal lesion expressed higher level of VEGF and lower level of TSP-1, whereas ovarian endometrioma expressed lower level VEGF and higher level of TSP-1. Eutopic endometrium of women with endometriosis had higer level of VEGF expression and lower level of TSP-1 expression than women without endometriosis. CONCLUSIONS: The expression of VEGF and TSP-1 in endometriotic lesion appears to be associated with its neovalscualization extent. The imbalance in expression of VEGF and TSP-1 in endometrium might be related to the development of endometriosis and its biological behavior. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/16136892/[Expression_of_vascular_endothelial_growth_factor_and_thrombospondin_1_in_the_ectopic_and_eutopic_endometrium_of_women_with_endometriosis]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -