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[Changes and relations of soluble plasma CD40L and matrix metalloproteinase-9 levels in patients with coronary heart disease].

Abstract

OBJECTIVE

To investigate the serum soluble CD40 ligand (sCD40L) levels in coronary heart disease and its relationship with MMP-9 and to explore the potential predicting factor for the acute coronary syndrome.

METHODS

Enzyme-linked immunosorbent assay was used to measure the sCD40L and MMP-9 in 79 patients with coronary heart disease.

RESULTS

sCD40L level was significantly higher in patients with acute coronary syndrome [(1.96 +/- 0.84) ng/ml and (2.23 +/- 0.99) ng/ml in unstable angina and acute myocardial infarction group, respectively] than in stable coronary heart disease patients [(1.20 +/- 0.76) ng/ml, P < 0.05]. Serum sCD40L was significantly correlated with MMP-9 (r = 0.401 , P < 0.01), and sCD40L level was significantly correlated with TG (r = 0.254, P = 0.039), HDL (r = -0.234, P = 0.031), and HDL-C (r = -0.253, P = 0.024).

CONCLUSION

Serum sCD40L and MMP-9 levels were elevated in acute coronary syndrome, suggesting the possible relation to the pathogenesis of ACS and it may serve as a potential marker of plaque stability.

Authors+Show Affiliations

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. lij8898@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16137036

Citation

Li, Jiang, et al. "[Changes and Relations of Soluble Plasma CD40L and Matrix Metalloproteinase-9 Levels in Patients With Coronary Heart Disease]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 29, no. 5, 2004, pp. 517-20.
Li J, Zhao SP, Peng DQ, et al. [Changes and relations of soluble plasma CD40L and matrix metalloproteinase-9 levels in patients with coronary heart disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004;29(5):517-20.
Li, J., Zhao, S. P., Peng, D. Q., & Zhou, H. N. (2004). [Changes and relations of soluble plasma CD40L and matrix metalloproteinase-9 levels in patients with coronary heart disease]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 29(5), pp. 517-20.
Li J, et al. [Changes and Relations of Soluble Plasma CD40L and Matrix Metalloproteinase-9 Levels in Patients With Coronary Heart Disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004;29(5):517-20. PubMed PMID: 16137036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes and relations of soluble plasma CD40L and matrix metalloproteinase-9 levels in patients with coronary heart disease]. AU - Li,Jiang, AU - Zhao,Shui-ping, AU - Peng,Dao-quan, AU - Zhou,Hong-nian, PY - 2005/9/3/pubmed PY - 2007/3/17/medline PY - 2005/9/3/entrez SP - 517 EP - 20 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 29 IS - 5 N2 - OBJECTIVE: To investigate the serum soluble CD40 ligand (sCD40L) levels in coronary heart disease and its relationship with MMP-9 and to explore the potential predicting factor for the acute coronary syndrome. METHODS: Enzyme-linked immunosorbent assay was used to measure the sCD40L and MMP-9 in 79 patients with coronary heart disease. RESULTS: sCD40L level was significantly higher in patients with acute coronary syndrome [(1.96 +/- 0.84) ng/ml and (2.23 +/- 0.99) ng/ml in unstable angina and acute myocardial infarction group, respectively] than in stable coronary heart disease patients [(1.20 +/- 0.76) ng/ml, P < 0.05]. Serum sCD40L was significantly correlated with MMP-9 (r = 0.401 , P < 0.01), and sCD40L level was significantly correlated with TG (r = 0.254, P = 0.039), HDL (r = -0.234, P = 0.031), and HDL-C (r = -0.253, P = 0.024). CONCLUSION: Serum sCD40L and MMP-9 levels were elevated in acute coronary syndrome, suggesting the possible relation to the pathogenesis of ACS and it may serve as a potential marker of plaque stability. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/16137036/[Changes_and_relations_of_soluble_plasma_CD40L_and_matrix_metalloproteinase_9_levels_in_patients_with_coronary_heart_disease]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/200410517.pdf DB - PRIME DP - Unbound Medicine ER -