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[Effect of jiuxinfumai injection on L-type calcium currents in single guinea pig ventricular myocytes].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Oct; 29(5):521-4.ZN

Abstract

OBJECTIVE

To determine the effect of 311 and 417, both active ingredients isolated from Jiuxinfumai injection (Citrus Aurantium) on L-type calcium currents (I(Ca-L)) in ventricular myocytes of guinea pigs.

METHODS

Single myocytes were dissociated by enzymatic dissociation method. The whole-cell patch-clamp recording technique was used to record the change of calcium current after the administration of 311and 417.

RESULTS

311 (10, 25, 50, 100 mmol/L) increased the (I(Ca-L)) by 8.27%, 27.29%, 41.01%, and 48.74% (P < 0.05), respectively. 417 (10, 25, 50, 100 mmol/L) increased the (I(Ca-L)) by 10.05%, 30.12%, 43.05%, and 51.90% (P < 0.05), respectively. Both 311 and 417 changed the (I(Ca-L)) significantly in a concentration-dependent manner. They did not change the shape of I-V cruves.

CONCLUSION

311 and 417 can increase I(I(Ca-L)) n ventricular myocytes of guinea pigs in a dose-response manner.

Authors+Show Affiliations

Fang F
School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China.
Song T
No affiliation info available
Xie LX
No affiliation info available
Liang SP
No affiliation info available
Liu ML
No affiliation info available
Zhou HH
No affiliation info available
Fang YX
No affiliation info available

MeSH

AnimalsCalcium Channels, L-TypeCitrusDose-Response Relationship, DrugDrugs, Chinese HerbalGuinea PigsHeart VentriclesMyocytes, CardiacPatch-Clamp Techniques

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16137037

Citation

Fang, Fang, et al. "[Effect of Jiuxinfumai Injection On L-type Calcium Currents in Single Guinea Pig Ventricular Myocytes]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 29, no. 5, 2004, pp. 521-4.
Fang F, Song T, Xie LX, et al. [Effect of jiuxinfumai injection on L-type calcium currents in single guinea pig ventricular myocytes]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004;29(5):521-4.
Fang, F., Song, T., Xie, L. X., Liang, S. P., Liu, M. L., Zhou, H. H., & Fang, Y. X. (2004). [Effect of jiuxinfumai injection on L-type calcium currents in single guinea pig ventricular myocytes]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 29(5), 521-4.
Fang F, et al. [Effect of Jiuxinfumai Injection On L-type Calcium Currents in Single Guinea Pig Ventricular Myocytes]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004;29(5):521-4. PubMed PMID: 16137037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of jiuxinfumai injection on L-type calcium currents in single guinea pig ventricular myocytes]. AU - Fang,Fang, AU - Song,Tao, AU - Xie,Li-xin, AU - Liang,Song-ping, AU - Liu,Mei-li, AU - Zhou,Hong-hao, AU - Fang,Yun-xiang, PY - 2005/9/3/pubmed PY - 2007/3/17/medline PY - 2005/9/3/entrez SP - 521 EP - 4 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 29 IS - 5 N2 - OBJECTIVE: To determine the effect of 311 and 417, both active ingredients isolated from Jiuxinfumai injection (Citrus Aurantium) on L-type calcium currents (I(Ca-L)) in ventricular myocytes of guinea pigs. METHODS: Single myocytes were dissociated by enzymatic dissociation method. The whole-cell patch-clamp recording technique was used to record the change of calcium current after the administration of 311and 417. RESULTS: 311 (10, 25, 50, 100 mmol/L) increased the (I(Ca-L)) by 8.27%, 27.29%, 41.01%, and 48.74% (P < 0.05), respectively. 417 (10, 25, 50, 100 mmol/L) increased the (I(Ca-L)) by 10.05%, 30.12%, 43.05%, and 51.90% (P < 0.05), respectively. Both 311 and 417 changed the (I(Ca-L)) significantly in a concentration-dependent manner. They did not change the shape of I-V cruves. CONCLUSION: 311 and 417 can increase I(I(Ca-L)) n ventricular myocytes of guinea pigs in a dose-response manner. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/16137037/[Effect_of_jiuxinfumai_injection_on_L_type_calcium_currents_in_single_guinea_pig_ventricular_myocytes]_ DB - PRIME DP - Unbound Medicine ER -