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Is the use o f Gunnera perpensa extracts in endometritis related to antibacterial activity?
Onderstepoort J Vet Res. 2005 Jun; 72(2):129-34.OJ

Abstract

Rhizome extracts of Gunnera perpensa are used in traditional remedies in South Africa to treat endometritis both in humans and animals. An investigation was undertaken to determine whether this plant possesses antibacterial activity, which may explain its efficacy. Gunnera perpensa rhizome extracts were prepared serially with solvents of increasing polarity and tested for antibacterial activity. Test bacteria included the Gram-positive Enterococcus faecalis and Staphylococcus aureus and the Gram-negative Escherichia coli and Pseudomonas aeruginosa. A moderate to weak level of antibacterial activity in most of the extracts resulted, with the best minimal inhibitory concentration (MIC) value of 2.61 mg ml(-1) shown by the acetone extract against S. aureus. The extracts were also submitted to the brine shrimp assay to detect possible toxic or pharmacological effects. All the extracts were lethal to the brine shrimp larvae at a concentration of 5 mg ml(-1). The acetone extract was extremely toxic at 1 mg ml(-1), with some toxicity evident at 0.1 mg ml(-1). The remainder of the extracts generally displayed little activity at concentrations lower than 5 mg ml(-1). In summary, the results indicate that although the extracts demonstrated a level of pharmacological activity, the relatively weak antibacterial activity is unlikely to justify the use of G. perpensa rhizomes in the traditional treatment of endometritis. Rather, the slightly antibacterial nature of the rhizomes may contribute to an additive effect, along with their known uterotonic activity, to the overall efficacy of the preparation.

Authors+Show Affiliations

Programme for Phytomedicine, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16137130

Citation

McGaw, L J., et al. "Is the Use O F Gunnera Perpensa Extracts in Endometritis Related to Antibacterial Activity?" The Onderstepoort Journal of Veterinary Research, vol. 72, no. 2, 2005, pp. 129-34.
McGaw LJ, Gehring R, Katsoulis L, et al. Is the use o f Gunnera perpensa extracts in endometritis related to antibacterial activity? Onderstepoort J Vet Res. 2005;72(2):129-34.
McGaw, L. J., Gehring, R., Katsoulis, L., & Eloff, J. N. (2005). Is the use o f Gunnera perpensa extracts in endometritis related to antibacterial activity? The Onderstepoort Journal of Veterinary Research, 72(2), 129-34.
McGaw LJ, et al. Is the Use O F Gunnera Perpensa Extracts in Endometritis Related to Antibacterial Activity. Onderstepoort J Vet Res. 2005;72(2):129-34. PubMed PMID: 16137130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the use o f Gunnera perpensa extracts in endometritis related to antibacterial activity? AU - McGaw,L J, AU - Gehring,R, AU - Katsoulis,L, AU - Eloff,J N, PY - 2005/9/3/pubmed PY - 2005/10/14/medline PY - 2005/9/3/entrez SP - 129 EP - 34 JF - The Onderstepoort journal of veterinary research JO - Onderstepoort J. Vet. Res. VL - 72 IS - 2 N2 - Rhizome extracts of Gunnera perpensa are used in traditional remedies in South Africa to treat endometritis both in humans and animals. An investigation was undertaken to determine whether this plant possesses antibacterial activity, which may explain its efficacy. Gunnera perpensa rhizome extracts were prepared serially with solvents of increasing polarity and tested for antibacterial activity. Test bacteria included the Gram-positive Enterococcus faecalis and Staphylococcus aureus and the Gram-negative Escherichia coli and Pseudomonas aeruginosa. A moderate to weak level of antibacterial activity in most of the extracts resulted, with the best minimal inhibitory concentration (MIC) value of 2.61 mg ml(-1) shown by the acetone extract against S. aureus. The extracts were also submitted to the brine shrimp assay to detect possible toxic or pharmacological effects. All the extracts were lethal to the brine shrimp larvae at a concentration of 5 mg ml(-1). The acetone extract was extremely toxic at 1 mg ml(-1), with some toxicity evident at 0.1 mg ml(-1). The remainder of the extracts generally displayed little activity at concentrations lower than 5 mg ml(-1). In summary, the results indicate that although the extracts demonstrated a level of pharmacological activity, the relatively weak antibacterial activity is unlikely to justify the use of G. perpensa rhizomes in the traditional treatment of endometritis. Rather, the slightly antibacterial nature of the rhizomes may contribute to an additive effect, along with their known uterotonic activity, to the overall efficacy of the preparation. SN - 0030-2465 UR - https://www.unboundmedicine.com/medline/citation/16137130/Is_the_use_o_f_Gunnera_perpensa_extracts_in_endometritis_related_to_antibacterial_activity L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -