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The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice.
Life Sci. 2005 Nov 26; 78(2):157-63.LS

Abstract

The measurement of step-down latency in passive avoidance has been used to study memory in laboratory animals. The pre-training injection of 5 mg/kg morphine impaired memory, which was restored when 24 h later the same dose of the drug was administered. To explore the possible involvement of NMDA modulators on morphine-induced memory impairment, we have investigated the effects of intracerebroventricular (i.c.v.) administration of NMDA and the competitive NMDA antagonist, DL-AP5, on morphine-induced memory impairment or recall, on the test day. Morphine (5 mg/kg, s.c.) was administered 30 min before training to induce impairment of memory and 24 h later, 30 min before test to improve it. Pre-test administration of NMDA (0.00001, 0.0001 and 0.001 microg/mouse, i.c.v.) did not alter the retention latency compared to the saline-treated animals. But restored the memory impairment induced by pre-training morphine (5 mg/kg, s.c.). Pre-test administration of DL-AP5 (1, 3.2 and 10 microg/mouse, i.c.v.) by itself decreased the retention latencies. The same doses of DL-AP5 increased pre-training morphine-induced memory impairment. Co-administration of NMDA (0.0001 and 0.001 microg/mouse, i.c.v.) and morphine (5 mg/kg, s.c.) on the test day increased morphine memory improvement. Conversely, DL-AP5 (1, 3.2 and 10 microg/mouse, i.c.v.) inhibited morphine-induced memory recall. It is concluded that NMDA receptors may be involved, at least in part, in morphine state-dependent learning in mice.

Authors+Show Affiliations

Jafari-Sabet M
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.
Zarrindast MR
No affiliation info available
Rezayat M
No affiliation info available
Rezayof A
No affiliation info available
Djahanguiri B
No affiliation info available

MeSH

2-Amino-5-phosphonovalerateAnimalsAvoidance LearningDose-Response Relationship, DrugExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsInjections, IntraventricularMaleMemoryMental RecallMiceMorphineN-MethylaspartateNarcoticsReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16137707

Citation

Jafari-Sabet, Majid, et al. "The Influence of NMDA Receptor Agonist and Antagonist On Morphine State-dependent Memory of Passive Avoidance in Mice." Life Sciences, vol. 78, no. 2, 2005, pp. 157-63.
Jafari-Sabet M, Zarrindast MR, Rezayat M, et al. The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice. Life Sci. 2005;78(2):157-63.
Jafari-Sabet, M., Zarrindast, M. R., Rezayat, M., Rezayof, A., & Djahanguiri, B. (2005). The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice. Life Sciences, 78(2), 157-63.
Jafari-Sabet M, et al. The Influence of NMDA Receptor Agonist and Antagonist On Morphine State-dependent Memory of Passive Avoidance in Mice. Life Sci. 2005 Nov 26;78(2):157-63. PubMed PMID: 16137707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice. AU - Jafari-Sabet,Majid, AU - Zarrindast,Mohammad-Reza, AU - Rezayat,Mehdi, AU - Rezayof,Ameneh, AU - Djahanguiri,Bijan, Y1 - 2005/08/30/ PY - 2004/11/22/received PY - 2005/04/15/accepted PY - 2005/9/3/pubmed PY - 2005/12/13/medline PY - 2005/9/3/entrez SP - 157 EP - 63 JF - Life sciences JO - Life Sci VL - 78 IS - 2 N2 - The measurement of step-down latency in passive avoidance has been used to study memory in laboratory animals. The pre-training injection of 5 mg/kg morphine impaired memory, which was restored when 24 h later the same dose of the drug was administered. To explore the possible involvement of NMDA modulators on morphine-induced memory impairment, we have investigated the effects of intracerebroventricular (i.c.v.) administration of NMDA and the competitive NMDA antagonist, DL-AP5, on morphine-induced memory impairment or recall, on the test day. Morphine (5 mg/kg, s.c.) was administered 30 min before training to induce impairment of memory and 24 h later, 30 min before test to improve it. Pre-test administration of NMDA (0.00001, 0.0001 and 0.001 microg/mouse, i.c.v.) did not alter the retention latency compared to the saline-treated animals. But restored the memory impairment induced by pre-training morphine (5 mg/kg, s.c.). Pre-test administration of DL-AP5 (1, 3.2 and 10 microg/mouse, i.c.v.) by itself decreased the retention latencies. The same doses of DL-AP5 increased pre-training morphine-induced memory impairment. Co-administration of NMDA (0.0001 and 0.001 microg/mouse, i.c.v.) and morphine (5 mg/kg, s.c.) on the test day increased morphine memory improvement. Conversely, DL-AP5 (1, 3.2 and 10 microg/mouse, i.c.v.) inhibited morphine-induced memory recall. It is concluded that NMDA receptors may be involved, at least in part, in morphine state-dependent learning in mice. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/16137707/The_influence_of_NMDA_receptor_agonist_and_antagonist_on_morphine_state_dependent_memory_of_passive_avoidance_in_mice_ DB - PRIME DP - Unbound Medicine ER -