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Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts.
J Ethnopharmacol. 2005 Dec 01; 102(3):450-6.JE

Abstract

The present study was conducted to investigate antibacterial activity of Zuccagnia punctata ethanolic extract against 47 strains of antibiotic-resistant Gram-negative bacteria and to identify bioactive compounds. Inhibition of bacterial growth was investigated using agar diffusion, agar macrodilution, broth microdilution and bioautographic methods. Zuccagnia punctata extract was active against all assayed bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia) with minimal inhibitory concentration (MIC) values ranging from 25 to 200 microg/mL. Minimal bactericidal concentration (MBC) values were identical or two-fold higher than the corresponding MIC values. Contact bioautography, indicated that Zuccagnia punctata extracts possess one major antibacterial component against Pseudomonas aeruginosa and at least three components against. Klebsiella pneumoniae and Escherichia coli. Activity-guided fractionation of 1he ethanol extract on a silica gel column yielded a compound (2',4'-dihydroxychalcone), which exhibited strong antibacterial activity with MIC values between 0.10 and 1.00 microg/mL for Proteus mirabilis, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia. These values are lower than imipenem (0.25-16 microg/mL). Zuccagnia punctata might provide promising therapeutic agents against infections with multi-resistant Gram-negative bacteria.

Authors+Show Affiliations

Cátedra de Fitoquimíca, Instituto de Estudios Vegetales Dr. Antonio R. Sampietro, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16137849

Citation

Zampini, Iris C., et al. "Antibacterial Activity of Zuccagnia Punctata Cav. Ethanolic Extracts." Journal of Ethnopharmacology, vol. 102, no. 3, 2005, pp. 450-6.
Zampini IC, Vattuone MA, Isla MI. Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts. J Ethnopharmacol. 2005;102(3):450-6.
Zampini, I. C., Vattuone, M. A., & Isla, M. I. (2005). Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts. Journal of Ethnopharmacology, 102(3), 450-6.
Zampini IC, Vattuone MA, Isla MI. Antibacterial Activity of Zuccagnia Punctata Cav. Ethanolic Extracts. J Ethnopharmacol. 2005 Dec 1;102(3):450-6. PubMed PMID: 16137849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts. AU - Zampini,Iris C, AU - Vattuone,Marta A, AU - Isla,Maria I, Y1 - 2005/08/30/ PY - 2004/10/01/received PY - 2005/07/13/revised PY - 2005/07/19/accepted PY - 2005/9/3/pubmed PY - 2006/3/17/medline PY - 2005/9/3/entrez SP - 450 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 102 IS - 3 N2 - The present study was conducted to investigate antibacterial activity of Zuccagnia punctata ethanolic extract against 47 strains of antibiotic-resistant Gram-negative bacteria and to identify bioactive compounds. Inhibition of bacterial growth was investigated using agar diffusion, agar macrodilution, broth microdilution and bioautographic methods. Zuccagnia punctata extract was active against all assayed bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia) with minimal inhibitory concentration (MIC) values ranging from 25 to 200 microg/mL. Minimal bactericidal concentration (MBC) values were identical or two-fold higher than the corresponding MIC values. Contact bioautography, indicated that Zuccagnia punctata extracts possess one major antibacterial component against Pseudomonas aeruginosa and at least three components against. Klebsiella pneumoniae and Escherichia coli. Activity-guided fractionation of 1he ethanol extract on a silica gel column yielded a compound (2',4'-dihydroxychalcone), which exhibited strong antibacterial activity with MIC values between 0.10 and 1.00 microg/mL for Proteus mirabilis, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia. These values are lower than imipenem (0.25-16 microg/mL). Zuccagnia punctata might provide promising therapeutic agents against infections with multi-resistant Gram-negative bacteria. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16137849/Antibacterial_activity_of_Zuccagnia_punctata_Cav__ethanolic_extracts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00461-7 DB - PRIME DP - Unbound Medicine ER -