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Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices.
J Biomed Mater Res A. 2006 Jan; 76(1):86-94.JB

Abstract

Diamond-like carbon (DLC) is being considered for widespread clinical use as a surface coating for cardiovascular devices. We synthesized fluorinated DLC (F-DLC) coatings in order to create a more hydrophobic surface with improved antithrombogenicity and flexibility when compared with conventional DLC coatings by combining the inertness of DLC films with the advantage of fluorination. The purpose of this study was to evaluate the in vitro hemocompatibility and in vivo biocompatibility of the F-DLC coating for medical devices. The in vitro whole blood model confirmed that platelet loss was lower in the F-DLC group than in the noncoated group (SUS316L), which suggests the adhesion of a smaller number of platelets to F-DLC-coated materials. Furthermore, the biomarkers of mechanically induced platelet activation (beta-thromboglobulin) and activated coagulation (thrombin-antithrombin-three complex) were markedly reduced in the F-DLC-coated group. In vivo rat implant model studies revealed no excessive local and systemic inflammatory responses in the F-DLC group. The thickness of the fibrous tissue capsule surrounding the F-DLC-coated disk was almost equal to that of the noncoated SUS316L disk, which has the favorable biocompatibility for metallic implant materials. F-DLC coating thus appears to be a promising candidate for use as a coating material in blood-contacting devices.

Authors+Show Affiliations

Department of Radiology, Tachikawa Hospital, 4-2-22 Nishiki-cho, Tachikawa, Tokyo, Japan 190-8531. teru_hasebe@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16138324

Citation

Hasebe, Terumitsu, et al. "Fluorinated Diamond-like Carbon as Antithrombogenic Coating for Blood-contacting Devices." Journal of Biomedical Materials Research. Part A, vol. 76, no. 1, 2006, pp. 86-94.
Hasebe T, Shimada A, Suzuki T, et al. Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices. J Biomed Mater Res A. 2006;76(1):86-94.
Hasebe, T., Shimada, A., Suzuki, T., Matsuoka, Y., Saito, T., Yohena, S., Kamijo, A., Shiraga, N., Higuchi, M., Kimura, K., Yoshimura, H., & Kuribayashi, S. (2006). Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices. Journal of Biomedical Materials Research. Part A, 76(1), 86-94.
Hasebe T, et al. Fluorinated Diamond-like Carbon as Antithrombogenic Coating for Blood-contacting Devices. J Biomed Mater Res A. 2006;76(1):86-94. PubMed PMID: 16138324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices. AU - Hasebe,Terumitsu, AU - Shimada,Atsushi, AU - Suzuki,Tetsuya, AU - Matsuoka,Yoshiaki, AU - Saito,Toshiya, AU - Yohena,Satoshi, AU - Kamijo,Aki, AU - Shiraga,Nobuyuki, AU - Higuchi,Mutsumi, AU - Kimura,Kanako, AU - Yoshimura,Hirokuni, AU - Kuribayashi,Sachio, PY - 2005/9/3/pubmed PY - 2006/3/28/medline PY - 2005/9/3/entrez SP - 86 EP - 94 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 76 IS - 1 N2 - Diamond-like carbon (DLC) is being considered for widespread clinical use as a surface coating for cardiovascular devices. We synthesized fluorinated DLC (F-DLC) coatings in order to create a more hydrophobic surface with improved antithrombogenicity and flexibility when compared with conventional DLC coatings by combining the inertness of DLC films with the advantage of fluorination. The purpose of this study was to evaluate the in vitro hemocompatibility and in vivo biocompatibility of the F-DLC coating for medical devices. The in vitro whole blood model confirmed that platelet loss was lower in the F-DLC group than in the noncoated group (SUS316L), which suggests the adhesion of a smaller number of platelets to F-DLC-coated materials. Furthermore, the biomarkers of mechanically induced platelet activation (beta-thromboglobulin) and activated coagulation (thrombin-antithrombin-three complex) were markedly reduced in the F-DLC-coated group. In vivo rat implant model studies revealed no excessive local and systemic inflammatory responses in the F-DLC group. The thickness of the fibrous tissue capsule surrounding the F-DLC-coated disk was almost equal to that of the noncoated SUS316L disk, which has the favorable biocompatibility for metallic implant materials. F-DLC coating thus appears to be a promising candidate for use as a coating material in blood-contacting devices. SN - 1549-3296 UR - https://www.unboundmedicine.com/medline/citation/16138324/Fluorinated_diamond_like_carbon_as_antithrombogenic_coating_for_blood_contacting_devices_ L2 - https://doi.org/10.1002/jbm.a.30512 DB - PRIME DP - Unbound Medicine ER -