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Circadian blood pressure rhythm is disturbed by nephrectomy.
Hypertens Res. 2005 Apr; 28(4):301-6.HR

Abstract

We recently illustrated a close relationship between glomerular filtration rate and circadian rhythm of blood pressure (BP) in patients with chronic kidney disease. However, it remains undetermined from such cross-sectional findings which occurs first, the loss of kidney function or the lack of nocturnal BP fall. In the present study, we examined whether circadian rhythm of BP is affected by unilateral nephrectomy for kidney donation to clarify this important issue. Fifteen healthy subjects (4 men, 11 women; aged 33 to 65 years; mean age 55 +/- 2 years) who underwent unilateral nephrectomy for kidney donation were studied. Ambulatory BP was monitored for 24 h, while serum and urinary samples were collected to estimate creatinine clearance before and on the 8th day after nephrectomy. Then, changes in the night/day ratios of mean arterial BP were analyzed in relation to the decrease in 24-h creatinine clearance as a marker of glomerular filtration rate by nephrectomy. Creatinine clearance was reduced by 29% in average from 84 +/- 6 to 60 +/- 4 ml/min by nephrectomy, while 24-h mean arterial BP values were 91 +/- 3 and 94 +/- 4 mmHg (p=0.08) before and after nephrectomy. Although mean BP (daytime, nighttime or night/day ratio) was not altered significantly by nephrectomy, the decrease in creatinine clearance was positively correlated with the increase in the night/ day ratio of mean BP (r=0.61, p=0.017). The decrease in creatinine clearance was not correlated with changes in either 24-h, daytime or nighttime mean BP. Our results suggest that unilateral nephrectomy disturbs the circadian rhythm of BP as a function of renal dysfunction without affecting absolute levels of BP. Non-dipping of BP seems the consequence of the loss of renal function, rather than the cause.

Authors+Show Affiliations

Goto N
Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
Uchida K
No affiliation info available
Morozumi K
No affiliation info available
Ueki T
No affiliation info available
Matsuoka S
No affiliation info available
Katayama A
No affiliation info available
Haba T
No affiliation info available
Tominaga Y
No affiliation info available
Fukuda M
No affiliation info available
Nakao A
No affiliation info available
Kimura G
No affiliation info available

MeSH

AdultAgedBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmCreatinineFemaleGlomerular Filtration RateHumansHypertension, RenalKidney TransplantationLiving DonorsMaleMiddle AgedNephrectomy

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16138559

Citation

Goto, Norihiko, et al. "Circadian Blood Pressure Rhythm Is Disturbed By Nephrectomy." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 28, no. 4, 2005, pp. 301-6.
Goto N, Uchida K, Morozumi K, et al. Circadian blood pressure rhythm is disturbed by nephrectomy. Hypertens Res. 2005;28(4):301-6.
Goto, N., Uchida, K., Morozumi, K., Ueki, T., Matsuoka, S., Katayama, A., Haba, T., Tominaga, Y., Fukuda, M., Nakao, A., & Kimura, G. (2005). Circadian blood pressure rhythm is disturbed by nephrectomy. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 28(4), 301-6.
Goto N, et al. Circadian Blood Pressure Rhythm Is Disturbed By Nephrectomy. Hypertens Res. 2005;28(4):301-6. PubMed PMID: 16138559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian blood pressure rhythm is disturbed by nephrectomy. AU - Goto,Norihiko, AU - Uchida,Kazuharu, AU - Morozumi,Kunio, AU - Ueki,Tsuneo, AU - Matsuoka,Susumu, AU - Katayama,Akio, AU - Haba,Toshihito, AU - Tominaga,Yoshihiro, AU - Fukuda,Michio, AU - Nakao,Akimasa, AU - Kimura,Genjiro, PY - 2005/9/6/pubmed PY - 2005/9/30/medline PY - 2005/9/6/entrez SP - 301 EP - 6 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 28 IS - 4 N2 - We recently illustrated a close relationship between glomerular filtration rate and circadian rhythm of blood pressure (BP) in patients with chronic kidney disease. However, it remains undetermined from such cross-sectional findings which occurs first, the loss of kidney function or the lack of nocturnal BP fall. In the present study, we examined whether circadian rhythm of BP is affected by unilateral nephrectomy for kidney donation to clarify this important issue. Fifteen healthy subjects (4 men, 11 women; aged 33 to 65 years; mean age 55 +/- 2 years) who underwent unilateral nephrectomy for kidney donation were studied. Ambulatory BP was monitored for 24 h, while serum and urinary samples were collected to estimate creatinine clearance before and on the 8th day after nephrectomy. Then, changes in the night/day ratios of mean arterial BP were analyzed in relation to the decrease in 24-h creatinine clearance as a marker of glomerular filtration rate by nephrectomy. Creatinine clearance was reduced by 29% in average from 84 +/- 6 to 60 +/- 4 ml/min by nephrectomy, while 24-h mean arterial BP values were 91 +/- 3 and 94 +/- 4 mmHg (p=0.08) before and after nephrectomy. Although mean BP (daytime, nighttime or night/day ratio) was not altered significantly by nephrectomy, the decrease in creatinine clearance was positively correlated with the increase in the night/ day ratio of mean BP (r=0.61, p=0.017). The decrease in creatinine clearance was not correlated with changes in either 24-h, daytime or nighttime mean BP. Our results suggest that unilateral nephrectomy disturbs the circadian rhythm of BP as a function of renal dysfunction without affecting absolute levels of BP. Non-dipping of BP seems the consequence of the loss of renal function, rather than the cause. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/16138559/Circadian_blood_pressure_rhythm_is_disturbed_by_nephrectomy_ DB - PRIME DP - Unbound Medicine ER -