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Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient mice.
Eur Neuropsychopharmacol. 2005 Oct; 15(5):587-90.EN

Abstract

Prepulse inhibition of acoustic startle is a behavioural response, which is used to estimate sensorimotor gating deficits in schizophrenia. Recent studies show that several behavioural effects of the psychotomimetic drug, phencyclidine (PCP), in rodents are blocked by nitric oxide synthase (NOS) inhibitors suggesting that NO plays an important role in the pharmacological effects of PCP. The present study was conducted to examine the effects of PCP on prepulse inhibition in neuronal NOS (nNOS) deficient mice. PCP treatment caused a significant and dose-related increase in prepulse inhibition in nNOS-/- mice whereas prepulse inhibition was not significantly affected in +/+ and +/- mice. Basal prepulse inhibition level did not differ significantly between the groups. Furthermore, PCP caused a dose-related decrease in startle response reactivity in +/+ mice but did not significantly affect this measure in +/- and -/- mice. Basal startle response level did not differ between +/+ and +/- but was significantly lower in -/- mice. It is concluded that nNOS plays a role in the NO-sensitive effects of PCP.

Authors+Show Affiliations

Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, POB 431, SE 405 30 Göteborg, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16139176

Citation

Klamer, Daniel, et al. "Effects of Phencyclidine On Acoustic Startle and Prepulse Inhibition in Neuronal Nitric Oxide Synthase Deficient Mice." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 15, no. 5, 2005, pp. 587-90.
Klamer D, Engel JA, Svensson L. Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient mice. Eur Neuropsychopharmacol. 2005;15(5):587-90.
Klamer, D., Engel, J. A., & Svensson, L. (2005). Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 15(5), 587-90.
Klamer D, Engel JA, Svensson L. Effects of Phencyclidine On Acoustic Startle and Prepulse Inhibition in Neuronal Nitric Oxide Synthase Deficient Mice. Eur Neuropsychopharmacol. 2005;15(5):587-90. PubMed PMID: 16139176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of phencyclidine on acoustic startle and prepulse inhibition in neuronal nitric oxide synthase deficient mice. AU - Klamer,Daniel, AU - Engel,Jörgen A, AU - Svensson,Lennart, Y1 - 2005/04/07/ PY - 2004/10/02/received PY - 2005/02/15/accepted PY - 2005/9/6/pubmed PY - 2005/12/31/medline PY - 2005/9/6/entrez SP - 587 EP - 90 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 15 IS - 5 N2 - Prepulse inhibition of acoustic startle is a behavioural response, which is used to estimate sensorimotor gating deficits in schizophrenia. Recent studies show that several behavioural effects of the psychotomimetic drug, phencyclidine (PCP), in rodents are blocked by nitric oxide synthase (NOS) inhibitors suggesting that NO plays an important role in the pharmacological effects of PCP. The present study was conducted to examine the effects of PCP on prepulse inhibition in neuronal NOS (nNOS) deficient mice. PCP treatment caused a significant and dose-related increase in prepulse inhibition in nNOS-/- mice whereas prepulse inhibition was not significantly affected in +/+ and +/- mice. Basal prepulse inhibition level did not differ significantly between the groups. Furthermore, PCP caused a dose-related decrease in startle response reactivity in +/+ mice but did not significantly affect this measure in +/- and -/- mice. Basal startle response level did not differ between +/+ and +/- but was significantly lower in -/- mice. It is concluded that nNOS plays a role in the NO-sensitive effects of PCP. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/16139176/Effects_of_phencyclidine_on_acoustic_startle_and_prepulse_inhibition_in_neuronal_nitric_oxide_synthase_deficient_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(05)00042-8 DB - PRIME DP - Unbound Medicine ER -