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Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats.
Eur Neuropsychopharmacol. 2006 Feb; 16(2):85-91.EN

Abstract

The aim of the present study was to evaluate the effect of an antioxidant vineatrol against kainic acid-induced seizures, markers of oxidative stress and expression of heat shock protein in brain. In rats, kainic acid (10 mg/kg i.p.) induced long lasting seizures, associated behavioral symptoms and brain damage and significantly increased level of brain malondialdehyde (MDA) (283 +/- 42 nmol/g wet tissue) as compared to control (173.3 +/- 10.2 nmol/g wet tissue). Pretreatment (5 min) of vineatrol (10, 20 and 40 mg/kg i.p.) could not inhibit the convulsions though the latency was significantly increased with 20 and 40 mg/kg. However when the drug was administrated 5 min prior and repeated at 30 and 90 min after kainic acid there was significant reduction in incidence of convulsions. The brain MDA levels were also found to be significantly attenuated, however the glutathione levels were not different in control, kainic acid and vineatrol treated animals. Expression of heat shock protein (HSP) 72 was observed in the kainic acid per se group indicating neurotoxicity as compared to the control group and was reduced by vineatrol. The study suggests the potential use of vineatrol in status epilepticus.

Authors+Show Affiliations

Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi. ykg@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16139993

Citation

Gupta, Yogendra Kumar, and Seema Briyal. "Protective Effect of Vineatrol Against Kainic Acid Induced Seizures, Oxidative Stress and On the Expression of Heat Shock Proteins in Rats." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 16, no. 2, 2006, pp. 85-91.
Gupta YK, Briyal S. Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats. Eur Neuropsychopharmacol. 2006;16(2):85-91.
Gupta, Y. K., & Briyal, S. (2006). Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 16(2), 85-91.
Gupta YK, Briyal S. Protective Effect of Vineatrol Against Kainic Acid Induced Seizures, Oxidative Stress and On the Expression of Heat Shock Proteins in Rats. Eur Neuropsychopharmacol. 2006;16(2):85-91. PubMed PMID: 16139993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats. AU - Gupta,Yogendra Kumar, AU - Briyal,Seema, Y1 - 2005/09/02/ PY - 2005/03/07/received PY - 2005/07/05/accepted PY - 2005/9/6/pubmed PY - 2006/5/2/medline PY - 2005/9/6/entrez SP - 85 EP - 91 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 16 IS - 2 N2 - The aim of the present study was to evaluate the effect of an antioxidant vineatrol against kainic acid-induced seizures, markers of oxidative stress and expression of heat shock protein in brain. In rats, kainic acid (10 mg/kg i.p.) induced long lasting seizures, associated behavioral symptoms and brain damage and significantly increased level of brain malondialdehyde (MDA) (283 +/- 42 nmol/g wet tissue) as compared to control (173.3 +/- 10.2 nmol/g wet tissue). Pretreatment (5 min) of vineatrol (10, 20 and 40 mg/kg i.p.) could not inhibit the convulsions though the latency was significantly increased with 20 and 40 mg/kg. However when the drug was administrated 5 min prior and repeated at 30 and 90 min after kainic acid there was significant reduction in incidence of convulsions. The brain MDA levels were also found to be significantly attenuated, however the glutathione levels were not different in control, kainic acid and vineatrol treated animals. Expression of heat shock protein (HSP) 72 was observed in the kainic acid per se group indicating neurotoxicity as compared to the control group and was reduced by vineatrol. The study suggests the potential use of vineatrol in status epilepticus. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/16139993/Protective_effect_of_vineatrol_against_kainic_acid_induced_seizures_oxidative_stress_and_on_the_expression_of_heat_shock_proteins_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(05)00106-9 DB - PRIME DP - Unbound Medicine ER -