Tags

Type your tag names separated by a space and hit enter

Adherence to asthma controller medication regimens.
Respir Med. 2005 Oct; 99(10):1263-7.RM

Abstract

BACKGROUND

Improved adherence to inhaled corticosteroids (ICS) is recognized as an important factor in reduced morbidity, mortality and consumption of health care resources. The present study was designed to replicate previous reports of patient adherence with fluticasone/salmeterol in a single inhaler (FSC), fluticasone and salmeterol in separate inhalers (FP+SAL), fluticasone and montelukast (FP+MON), fluticasone alone (FP) and montelukast alone (MON).

METHODS

A 24-month observational retrospective study was conducted using administrative claims data. Subjects were 12 years old with 24 months of continuous enrollment; had 1 asthma claim (ICD-9: 493), 1 short-acting beta(2)-agonist claim, and 1 FSC, FP, SAL, or MON claim. Outcomes included asthma medication refill rates and persistence measured by treatment days. This study was designed with a unique population of patients with asthma from different health plans to validate previous findings.

RESULTS

A total of 3,503 subjects were identified based on their index medication: FSC (996), FP+SAL (259), FP+MON (101), FP (1254) and MON (893). Mean number of prescription refills for FSC (3.98) was significantly higher than FP (2.29) and the FP component of FP+SAL (2.36), and FP+MON (2.15), P<0.05. No significant differences were observed between FSC and MON fill rates (4.33). Mean number of treatment days was greater for FSC compared to FP, FP+SAL, and FP+MON (P<0.0001).

CONCLUSION

This study confirms a previous report that adherence profiles of fluticasone and salmeterol in a single inhaler are significantly better when compared to the controller regimens of fluticasone and salmeterol in separate inhalers, fluticasone and montelukast, or fluticasone alone and similar to montelukast alone.

Authors+Show Affiliations

Department of Pediatrics, Infomed Northwest and University of Washington, Bellevue, WA 98004, USA. econmed@msn.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16140227

Citation

Stempel, D A., et al. "Adherence to Asthma Controller Medication Regimens." Respiratory Medicine, vol. 99, no. 10, 2005, pp. 1263-7.
Stempel DA, Stoloff SW, Carranza Rosenzweig JR, et al. Adherence to asthma controller medication regimens. Respir Med. 2005;99(10):1263-7.
Stempel, D. A., Stoloff, S. W., Carranza Rosenzweig, J. R., Stanford, R. H., Ryskina, K. L., & Legorreta, A. P. (2005). Adherence to asthma controller medication regimens. Respiratory Medicine, 99(10), 1263-7.
Stempel DA, et al. Adherence to Asthma Controller Medication Regimens. Respir Med. 2005;99(10):1263-7. PubMed PMID: 16140227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to asthma controller medication regimens. AU - Stempel,D A, AU - Stoloff,S W, AU - Carranza Rosenzweig,J R, AU - Stanford,R H, AU - Ryskina,K L, AU - Legorreta,A P, Y1 - 2005/04/12/ PY - 2004/11/22/received PY - 2005/9/6/pubmed PY - 2006/3/7/medline PY - 2005/9/6/entrez SP - 1263 EP - 7 JF - Respiratory medicine JO - Respir Med VL - 99 IS - 10 N2 - BACKGROUND: Improved adherence to inhaled corticosteroids (ICS) is recognized as an important factor in reduced morbidity, mortality and consumption of health care resources. The present study was designed to replicate previous reports of patient adherence with fluticasone/salmeterol in a single inhaler (FSC), fluticasone and salmeterol in separate inhalers (FP+SAL), fluticasone and montelukast (FP+MON), fluticasone alone (FP) and montelukast alone (MON). METHODS: A 24-month observational retrospective study was conducted using administrative claims data. Subjects were 12 years old with 24 months of continuous enrollment; had 1 asthma claim (ICD-9: 493), 1 short-acting beta(2)-agonist claim, and 1 FSC, FP, SAL, or MON claim. Outcomes included asthma medication refill rates and persistence measured by treatment days. This study was designed with a unique population of patients with asthma from different health plans to validate previous findings. RESULTS: A total of 3,503 subjects were identified based on their index medication: FSC (996), FP+SAL (259), FP+MON (101), FP (1254) and MON (893). Mean number of prescription refills for FSC (3.98) was significantly higher than FP (2.29) and the FP component of FP+SAL (2.36), and FP+MON (2.15), P<0.05. No significant differences were observed between FSC and MON fill rates (4.33). Mean number of treatment days was greater for FSC compared to FP, FP+SAL, and FP+MON (P<0.0001). CONCLUSION: This study confirms a previous report that adherence profiles of fluticasone and salmeterol in a single inhaler are significantly better when compared to the controller regimens of fluticasone and salmeterol in separate inhalers, fluticasone and montelukast, or fluticasone alone and similar to montelukast alone. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/16140227/Adherence_to_asthma_controller_medication_regimens_ DB - PRIME DP - Unbound Medicine ER -