Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative?Int J Pediatr Otorhinolaryngol 2006; 70(2):275-85IJ
Abstract
BACKGROUND
Based on two clinical trials in healthy infants the American Academy of Pediatrics (AAP) advices immunization with a 7-valent pneumococcal conjugate vaccine in children with recurrent acute otitis media (AOM).
OBJECTIVE
To study the efficacy of a 7-valent pneumococcal conjugate vaccine on acute otitis media recurrences, its immunogenicity and impact on nasopharyngeal Streptococcus pneumoniae carriage in children with a history of frequent acute otitis media.
METHODS
In this double-blind, randomized study, 74 Belgian children, aged 1-7 years, with at least 2 clinically diagnosed episodes of acute otitis media in the previous year were enrolled. Children were immunized with either a 7-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide booster or a control hepatitis A vaccine. Total follow-up was 26 months.
RESULTS
Despite adequate serum IgG responses to all conjugate vaccine pneumococcal serotypes, no reduction of acute otitis media episodes was observed in the pneumococcal vaccine group as compared to the control group (rate ratio: 1.16; 95% CI: 0.69-1.96). Overall nasopharyngeal pneumococcal carriage remained stable. However, a transient shift from conjugate vaccine related S. pneumoniae serogroups to non-vaccine related serogroups was noted following conjugate vaccination.
CONCLUSION
Clinically no protective effect of pneumococcal conjugate vaccination on acute otitis media recurrences was found in children with a history of frequent AOM.
Links
MeSH
Acute DiseaseCarrier StateChildChild, PreschoolDouble-Blind MethodFemaleFollow-Up StudiesHepatitis A VaccinesHumansImmunization, SecondaryImmunoglobulin GInfantMaleMiddle Ear VentilationNasopharynxOtitis MediaPneumococcal InfectionsPneumococcal VaccinesSecondary PreventionStreptococcus pneumoniaeTreatment OutcomeVaccines, Conjugate
Pub Type(s)
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
16140397
Citation
van Kempen, Muriel J P., et al. "Pneumococcal Conjugate Vaccination in Children With Recurrent Acute Otitis Media: a Therapeutic Alternative?" International Journal of Pediatric Otorhinolaryngology, vol. 70, no. 2, 2006, pp. 275-85.
van Kempen MJ, Vermeiren JS, Vaneechoutte M, et al. Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? Int J Pediatr Otorhinolaryngol. 2006;70(2):275-85.
van Kempen, M. J., Vermeiren, J. S., Vaneechoutte, M., Claeys, G., Veenhoven, R. H., Rijkers, G. T., ... Dhooge, I. J. (2006). Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? International Journal of Pediatric Otorhinolaryngology, 70(2), pp. 275-85.
van Kempen MJ, et al. Pneumococcal Conjugate Vaccination in Children With Recurrent Acute Otitis Media: a Therapeutic Alternative. Int J Pediatr Otorhinolaryngol. 2006;70(2):275-85. PubMed PMID: 16140397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative?
AU - van Kempen,Muriel J P,
AU - Vermeiren,Judith S,
AU - Vaneechoutte,Mario,
AU - Claeys,Geert,
AU - Veenhoven,Reinier H,
AU - Rijkers,Ger T,
AU - Sanders,Elisabeth A M,
AU - Dhooge,Ingeborg J,
Y1 - 2005/09/02/
PY - 2005/01/31/received
PY - 2005/06/24/accepted
PY - 2005/9/6/pubmed
PY - 2007/5/18/medline
PY - 2005/9/6/entrez
SP - 275
EP - 85
JF - International journal of pediatric otorhinolaryngology
JO - Int. J. Pediatr. Otorhinolaryngol.
VL - 70
IS - 2
N2 - BACKGROUND: Based on two clinical trials in healthy infants the American Academy of Pediatrics (AAP) advices immunization with a 7-valent pneumococcal conjugate vaccine in children with recurrent acute otitis media (AOM). OBJECTIVE: To study the efficacy of a 7-valent pneumococcal conjugate vaccine on acute otitis media recurrences, its immunogenicity and impact on nasopharyngeal Streptococcus pneumoniae carriage in children with a history of frequent acute otitis media. METHODS: In this double-blind, randomized study, 74 Belgian children, aged 1-7 years, with at least 2 clinically diagnosed episodes of acute otitis media in the previous year were enrolled. Children were immunized with either a 7-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide booster or a control hepatitis A vaccine. Total follow-up was 26 months. RESULTS: Despite adequate serum IgG responses to all conjugate vaccine pneumococcal serotypes, no reduction of acute otitis media episodes was observed in the pneumococcal vaccine group as compared to the control group (rate ratio: 1.16; 95% CI: 0.69-1.96). Overall nasopharyngeal pneumococcal carriage remained stable. However, a transient shift from conjugate vaccine related S. pneumoniae serogroups to non-vaccine related serogroups was noted following conjugate vaccination. CONCLUSION: Clinically no protective effect of pneumococcal conjugate vaccination on acute otitis media recurrences was found in children with a history of frequent AOM.
SN - 0165-5876
UR - https://www.unboundmedicine.com/medline/citation/16140397/Pneumococcal_conjugate_vaccination_in_children_with_recurrent_acute_otitis_media:_a_therapeutic_alternative
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(05)00326-5
DB - PRIME
DP - Unbound Medicine
ER -
