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Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative?
Int J Pediatr Otorhinolaryngol 2006; 70(2):275-85IJ

Abstract

BACKGROUND

Based on two clinical trials in healthy infants the American Academy of Pediatrics (AAP) advices immunization with a 7-valent pneumococcal conjugate vaccine in children with recurrent acute otitis media (AOM).

OBJECTIVE

To study the efficacy of a 7-valent pneumococcal conjugate vaccine on acute otitis media recurrences, its immunogenicity and impact on nasopharyngeal Streptococcus pneumoniae carriage in children with a history of frequent acute otitis media.

METHODS

In this double-blind, randomized study, 74 Belgian children, aged 1-7 years, with at least 2 clinically diagnosed episodes of acute otitis media in the previous year were enrolled. Children were immunized with either a 7-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide booster or a control hepatitis A vaccine. Total follow-up was 26 months.

RESULTS

Despite adequate serum IgG responses to all conjugate vaccine pneumococcal serotypes, no reduction of acute otitis media episodes was observed in the pneumococcal vaccine group as compared to the control group (rate ratio: 1.16; 95% CI: 0.69-1.96). Overall nasopharyngeal pneumococcal carriage remained stable. However, a transient shift from conjugate vaccine related S. pneumoniae serogroups to non-vaccine related serogroups was noted following conjugate vaccination.

CONCLUSION

Clinically no protective effect of pneumococcal conjugate vaccination on acute otitis media recurrences was found in children with a history of frequent AOM.

Authors+Show Affiliations

Department of Otorhinolaryngology, Ghent University Hospital, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16140397

Citation

van Kempen, Muriel J P., et al. "Pneumococcal Conjugate Vaccination in Children With Recurrent Acute Otitis Media: a Therapeutic Alternative?" International Journal of Pediatric Otorhinolaryngology, vol. 70, no. 2, 2006, pp. 275-85.
van Kempen MJ, Vermeiren JS, Vaneechoutte M, et al. Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? Int J Pediatr Otorhinolaryngol. 2006;70(2):275-85.
van Kempen, M. J., Vermeiren, J. S., Vaneechoutte, M., Claeys, G., Veenhoven, R. H., Rijkers, G. T., ... Dhooge, I. J. (2006). Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? International Journal of Pediatric Otorhinolaryngology, 70(2), pp. 275-85.
van Kempen MJ, et al. Pneumococcal Conjugate Vaccination in Children With Recurrent Acute Otitis Media: a Therapeutic Alternative. Int J Pediatr Otorhinolaryngol. 2006;70(2):275-85. PubMed PMID: 16140397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? AU - van Kempen,Muriel J P, AU - Vermeiren,Judith S, AU - Vaneechoutte,Mario, AU - Claeys,Geert, AU - Veenhoven,Reinier H, AU - Rijkers,Ger T, AU - Sanders,Elisabeth A M, AU - Dhooge,Ingeborg J, Y1 - 2005/09/02/ PY - 2005/01/31/received PY - 2005/06/24/accepted PY - 2005/9/6/pubmed PY - 2007/5/18/medline PY - 2005/9/6/entrez SP - 275 EP - 85 JF - International journal of pediatric otorhinolaryngology JO - Int. J. Pediatr. Otorhinolaryngol. VL - 70 IS - 2 N2 - BACKGROUND: Based on two clinical trials in healthy infants the American Academy of Pediatrics (AAP) advices immunization with a 7-valent pneumococcal conjugate vaccine in children with recurrent acute otitis media (AOM). OBJECTIVE: To study the efficacy of a 7-valent pneumococcal conjugate vaccine on acute otitis media recurrences, its immunogenicity and impact on nasopharyngeal Streptococcus pneumoniae carriage in children with a history of frequent acute otitis media. METHODS: In this double-blind, randomized study, 74 Belgian children, aged 1-7 years, with at least 2 clinically diagnosed episodes of acute otitis media in the previous year were enrolled. Children were immunized with either a 7-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide booster or a control hepatitis A vaccine. Total follow-up was 26 months. RESULTS: Despite adequate serum IgG responses to all conjugate vaccine pneumococcal serotypes, no reduction of acute otitis media episodes was observed in the pneumococcal vaccine group as compared to the control group (rate ratio: 1.16; 95% CI: 0.69-1.96). Overall nasopharyngeal pneumococcal carriage remained stable. However, a transient shift from conjugate vaccine related S. pneumoniae serogroups to non-vaccine related serogroups was noted following conjugate vaccination. CONCLUSION: Clinically no protective effect of pneumococcal conjugate vaccination on acute otitis media recurrences was found in children with a history of frequent AOM. SN - 0165-5876 UR - https://www.unboundmedicine.com/medline/citation/16140397/Pneumococcal_conjugate_vaccination_in_children_with_recurrent_acute_otitis_media:_a_therapeutic_alternative L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(05)00326-5 DB - PRIME DP - Unbound Medicine ER -