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Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer.
Clin Nutr. 2005 Dec; 24(6):998-1004.CN

Abstract

BACKGROUND & AIMS

There are few well-designed studies evaluating the effect of oral nutrition supplements in patients with cancer cachexia. The aim of this study, in a posthoc analysis, was to examine the effect of dietary compliance on intake and body composition in patients with unresectable pancreatic cancer.

METHODS

Two hundred patients were randomised to receive 2 cans/day of a protein and energy dense, oral nutrition supplement+/-n-3 fatty acids in an international, multi-centre randomised trial over 8 weeks. Dietary compliance was defined a priori as consumption of a minimum of 1.5 cans/day of either supplement. Body composition, dietary intake and quality of life were measured at baseline, 4 and 8 weeks.

RESULTS

On average, there were significant differences in energy intake (501 kcal), protein intake (25.4 g) and weight (1.7 kg) between patients who were compliant with the nutrition prescription compared to noncompliant patients controlling for n-3 fatty acid randomisation, baseline weight and quality of life. Over the 8-week period, there was significant improvement in weight only. There was no significant difference in the energy intake from meals of the total group over the 8 weeks.

CONCLUSIONS

Compliance with the prescription of 1.5 cans of a protein and energy dense, oral nutrition supplement +/-n-3 fatty acids improved nutrition related outcomes in untreated pancreatic cancer patients. This level of supplement intake does not inhibit meal intake.

Authors+Show Affiliations

The Wesley Research Institute, Brisbane, Australia. judithba@wesley.com.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16140426

Citation

Bauer, Judith, et al. "Compliance With Nutrition Prescription Improves Outcomes in Patients With Unresectable Pancreatic Cancer." Clinical Nutrition (Edinburgh, Scotland), vol. 24, no. 6, 2005, pp. 998-1004.
Bauer J, Capra S, Battistutta D, et al. Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer. Clin Nutr. 2005;24(6):998-1004.
Bauer, J., Capra, S., Battistutta, D., Davidson, W., & Ash, S. (2005). Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer. Clinical Nutrition (Edinburgh, Scotland), 24(6), 998-1004.
Bauer J, et al. Compliance With Nutrition Prescription Improves Outcomes in Patients With Unresectable Pancreatic Cancer. Clin Nutr. 2005;24(6):998-1004. PubMed PMID: 16140426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer. AU - Bauer,Judith, AU - Capra,Sandra, AU - Battistutta,Diana, AU - Davidson,Wendy, AU - Ash,Susan, AU - ,, Y1 - 2005/09/06/ PY - 2005/01/05/received PY - 2005/07/22/accepted PY - 2005/9/6/pubmed PY - 2006/3/11/medline PY - 2005/9/6/entrez SP - 998 EP - 1004 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 24 IS - 6 N2 - BACKGROUND & AIMS: There are few well-designed studies evaluating the effect of oral nutrition supplements in patients with cancer cachexia. The aim of this study, in a posthoc analysis, was to examine the effect of dietary compliance on intake and body composition in patients with unresectable pancreatic cancer. METHODS: Two hundred patients were randomised to receive 2 cans/day of a protein and energy dense, oral nutrition supplement+/-n-3 fatty acids in an international, multi-centre randomised trial over 8 weeks. Dietary compliance was defined a priori as consumption of a minimum of 1.5 cans/day of either supplement. Body composition, dietary intake and quality of life were measured at baseline, 4 and 8 weeks. RESULTS: On average, there were significant differences in energy intake (501 kcal), protein intake (25.4 g) and weight (1.7 kg) between patients who were compliant with the nutrition prescription compared to noncompliant patients controlling for n-3 fatty acid randomisation, baseline weight and quality of life. Over the 8-week period, there was significant improvement in weight only. There was no significant difference in the energy intake from meals of the total group over the 8 weeks. CONCLUSIONS: Compliance with the prescription of 1.5 cans of a protein and energy dense, oral nutrition supplement +/-n-3 fatty acids improved nutrition related outcomes in untreated pancreatic cancer patients. This level of supplement intake does not inhibit meal intake. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/16140426/Compliance_with_nutrition_prescription_improves_outcomes_in_patients_with_unresectable_pancreatic_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(05)00130-5 DB - PRIME DP - Unbound Medicine ER -