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Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction.
Pharmacol Res. 2005 Dec; 52(6):485-90.PR

Abstract

Combined treatments with non-steroidal anti-inflammatory drugs and antibiotics may offer significant benefits in the prevention of pain and infections associated with oral surgery. In this study, piroxicam and azithromycin were administered to patients undergoing dental extraction to examine the efficacy of piroxicam in the prevention of post-operative pain and inflammatory complications, either in the absence or in the presence of a concomitant antibiotic treatment. Thirty patients were randomly assigned to three groups and treated for 3 days, before impacted lower third molar removal, as follows: (1) sublingual piroxicam-FDDF (fast dissolving dosage formulation) 20 mg/day; (2) oral azithromycin 500 mg/day; (3) piroxicam-FDDF 20 mg/day plus azithromycin 500 mg/day. Oral acetaminophen (500 mg tablets) was allowed as rescue analgesic medication. Pain intensity was evaluated on a 100-mm visual-analogue scale after dental extraction (day 1), and at days 2, 3, 7 after surgery. Edema and trismus were estimated at days 2 and 7. At days 1 and 2, pain intensity was significantly lower in patients treated with piroxicam-FDDF, either alone (p < 0.05) or in combination with azithromycin (p < 0.05), than in patients administered with azithromycin alone. A higher acetaminophen consumption was also recorded in the latter group (p < 0.01). Pain intensity values did not differ among treatment groups at days 3 and 7. At day 2, the facial edema was significantly less intense in patients exposed to piroxicam-FDDF alone, as compared to patients treated with azithromycin, either alone (p < 0.05) or in combination with piroxicam-FDDF (p < 0.05). No significant differences were detected when comparing groups for trismus at days 2 and 7. The present results indicate that, when given alone in the pre-operative period, piroxicam-FDDF effectively counteracts post-surgical pain and inflammatory reactions in oral tissues. Upon combined treatment with piroxicam-FDDF and azithromycin, the macrolide antibiotic may reduce the influence of piroxicam on post-operative inflammation, without affecting its beneficial effect on surgical pain.

Authors+Show Affiliations

Section of Oral Surgery, Department of Neurosciences, University of Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16140544

Citation

Graziani, F, et al. "Clinical Evaluation of piroxicam-FDDF and Azithromycin in the Prevention of Complications Associated With Impacted Lower Third Molar Extraction." Pharmacological Research, vol. 52, no. 6, 2005, pp. 485-90.
Graziani F, Corsi L, Fornai M, et al. Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. Pharmacol Res. 2005;52(6):485-90.
Graziani, F., Corsi, L., Fornai, M., Antonioli, L., Tonelli, M., Cei, S., Colucci, R., Blandizzi, C., Gabriele, M., & Del Tacca, M. (2005). Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. Pharmacological Research, 52(6), 485-90.
Graziani F, et al. Clinical Evaluation of piroxicam-FDDF and Azithromycin in the Prevention of Complications Associated With Impacted Lower Third Molar Extraction. Pharmacol Res. 2005;52(6):485-90. PubMed PMID: 16140544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. AU - Graziani,F, AU - Corsi,L, AU - Fornai,M, AU - Antonioli,L, AU - Tonelli,M, AU - Cei,S, AU - Colucci,R, AU - Blandizzi,C, AU - Gabriele,M, AU - Del Tacca,M, Y1 - 2005/09/02/ PY - 2005/06/08/received PY - 2005/07/27/revised PY - 2005/07/29/accepted PY - 2005/9/6/pubmed PY - 2005/12/24/medline PY - 2005/9/6/entrez SP - 485 EP - 90 JF - Pharmacological research JO - Pharmacol Res VL - 52 IS - 6 N2 - Combined treatments with non-steroidal anti-inflammatory drugs and antibiotics may offer significant benefits in the prevention of pain and infections associated with oral surgery. In this study, piroxicam and azithromycin were administered to patients undergoing dental extraction to examine the efficacy of piroxicam in the prevention of post-operative pain and inflammatory complications, either in the absence or in the presence of a concomitant antibiotic treatment. Thirty patients were randomly assigned to three groups and treated for 3 days, before impacted lower third molar removal, as follows: (1) sublingual piroxicam-FDDF (fast dissolving dosage formulation) 20 mg/day; (2) oral azithromycin 500 mg/day; (3) piroxicam-FDDF 20 mg/day plus azithromycin 500 mg/day. Oral acetaminophen (500 mg tablets) was allowed as rescue analgesic medication. Pain intensity was evaluated on a 100-mm visual-analogue scale after dental extraction (day 1), and at days 2, 3, 7 after surgery. Edema and trismus were estimated at days 2 and 7. At days 1 and 2, pain intensity was significantly lower in patients treated with piroxicam-FDDF, either alone (p < 0.05) or in combination with azithromycin (p < 0.05), than in patients administered with azithromycin alone. A higher acetaminophen consumption was also recorded in the latter group (p < 0.01). Pain intensity values did not differ among treatment groups at days 3 and 7. At day 2, the facial edema was significantly less intense in patients exposed to piroxicam-FDDF alone, as compared to patients treated with azithromycin, either alone (p < 0.05) or in combination with piroxicam-FDDF (p < 0.05). No significant differences were detected when comparing groups for trismus at days 2 and 7. The present results indicate that, when given alone in the pre-operative period, piroxicam-FDDF effectively counteracts post-surgical pain and inflammatory reactions in oral tissues. Upon combined treatment with piroxicam-FDDF and azithromycin, the macrolide antibiotic may reduce the influence of piroxicam on post-operative inflammation, without affecting its beneficial effect on surgical pain. SN - 1043-6618 UR - https://www.unboundmedicine.com/medline/citation/16140544/Clinical_evaluation_of_piroxicam_FDDF_and_azithromycin_in_the_prevention_of_complications_associated_with_impacted_lower_third_molar_extraction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(05)00150-7 DB - PRIME DP - Unbound Medicine ER -