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The emerging importance of cortical spreading depression in migraine headache.
Rev Neurol (Paris) 2005; 161(6-7):655-7RN

Abstract

Migraine is a disabling neurovascular disorder with a complex pathophysiology. Functional imaging and magneto encephalographic studies strongly suggest that Cortical Spreading Depression (CSD) constitutes the biological basis for the neurologic aura that precedes headache in one fourth of migrainers. It is likely that the aura is the generator of the headache since experimentally, CSD triggers the activation of the trigeminovascular system, possibly through matrix metalloproteases activation which is associated with an increase in vascular permeability. These data may have therapeutic implications: strategies to block trigeminal activation or its downstream consequences are central to treat the acute headache whereas strategies to block events lying upstream of trigeminal activation would be crucial in prophylaxis.

Authors+Show Affiliations

Department of Neurology, Gazi University Hospitals, Ankara, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16141950

Citation

Bolay, H, and M A. Moskowitz. "The Emerging Importance of Cortical Spreading Depression in Migraine Headache." Revue Neurologique, vol. 161, no. 6-7, 2005, pp. 655-7.
Bolay H, Moskowitz MA. The emerging importance of cortical spreading depression in migraine headache. Rev Neurol (Paris). 2005;161(6-7):655-7.
Bolay, H., & Moskowitz, M. A. (2005). The emerging importance of cortical spreading depression in migraine headache. Revue Neurologique, 161(6-7), pp. 655-7.
Bolay H, Moskowitz MA. The Emerging Importance of Cortical Spreading Depression in Migraine Headache. Rev Neurol (Paris). 2005;161(6-7):655-7. PubMed PMID: 16141950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emerging importance of cortical spreading depression in migraine headache. AU - Bolay,H, AU - Moskowitz,M A, PY - 2005/9/6/pubmed PY - 2005/10/20/medline PY - 2005/9/6/entrez SP - 655 EP - 7 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 161 IS - 6-7 N2 - Migraine is a disabling neurovascular disorder with a complex pathophysiology. Functional imaging and magneto encephalographic studies strongly suggest that Cortical Spreading Depression (CSD) constitutes the biological basis for the neurologic aura that precedes headache in one fourth of migrainers. It is likely that the aura is the generator of the headache since experimentally, CSD triggers the activation of the trigeminovascular system, possibly through matrix metalloproteases activation which is associated with an increase in vascular permeability. These data may have therapeutic implications: strategies to block trigeminal activation or its downstream consequences are central to treat the acute headache whereas strategies to block events lying upstream of trigeminal activation would be crucial in prophylaxis. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/16141950/The_emerging_importance_of_cortical_spreading_depression_in_migraine_headache_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-RN-07-2005-161-6-7-0035-3787-101019-200503739 DB - PRIME DP - Unbound Medicine ER -