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Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes.
J Rheumatol 2005; 32(9):1673-8JR

Abstract

OBJECTIVE

To investigate whether polymorphisms in the tumor necrosis factor receptor I (TNFRSF1A) and receptor II (TNFRSF1B) genes are associated with the anemia observed in rheumatoid arthritis (RA).

METHODS

We studied a group of Caucasian patients (n = 160) with established RA on whom longitudinal data of hemoglobin (Hb) levels over 5 years were recorded. A second group of patients (n = 102) with early RA was used for a confirmation study. Polymerase chain reaction restriction fragment length polymorphism analysis was used to genotype patients for the A36G polymorphism in the TNFRSF1A gene, and the T676G polymorphism in TNFRSF1B. Serum levels of ferritin were determined by ELISA and used to differentiate between iron deficiency anemia (IDA) and anemia of chronic disease (ACD). Data were analyzed by Kruskal-Wallis analysis of variance and logistic regression analysis.

RESULTS

The TNFRSF1A GG genotype was associated with lower 5-year mean area under the curve Hb levels compared with other genotypes (p = 0.01). Analysis of anemic status showed an increased frequency of anemia in patients carrying a G allele, with the highest frequency in GG homozygotes. The TNFRSF1A GG genotype was significantly associated with IDA in established RA (OR 4.3, p = 0.01), and this was confirmed in a group of patients with early RA (OR 4.8, p = 0.04). Analysis of the combined groups also showed a weak association of the G allele with ACD (OR 2.2, p = 0.04). No association was found between TNFRSF1B variants and anemia when the cohorts were analyzed separately, but an association between carriage of the T allele and ACD was found when the 2 groups were combined (OR 11.5, p = 0.01).

CONCLUSION

Our data suggest that polymorphisms within the TNFRSF1A and TNFRSF1B genes are associated with IDA and/or ACD in patients with RA.

Authors+Show Affiliations

Institute of Science and Technology in Medicine, Keele University.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16142859

Citation

Glossop, John R., et al. "Anemia in Rheumatoid Arthritis: Association With Polymorphism in the Tumor Necrosis Factor Receptor I and II Genes." The Journal of Rheumatology, vol. 32, no. 9, 2005, pp. 1673-8.
Glossop JR, Dawes PT, Hassell AB, et al. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. J Rheumatol. 2005;32(9):1673-8.
Glossop, J. R., Dawes, P. T., Hassell, A. B., & Mattey, D. L. (2005). Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. The Journal of Rheumatology, 32(9), pp. 1673-8.
Glossop JR, et al. Anemia in Rheumatoid Arthritis: Association With Polymorphism in the Tumor Necrosis Factor Receptor I and II Genes. J Rheumatol. 2005;32(9):1673-8. PubMed PMID: 16142859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. AU - Glossop,John R, AU - Dawes,Peter T, AU - Hassell,Andrew B, AU - Mattey,Derek L, PY - 2005/9/6/pubmed PY - 2005/11/16/medline PY - 2005/9/6/entrez SP - 1673 EP - 8 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 32 IS - 9 N2 - OBJECTIVE: To investigate whether polymorphisms in the tumor necrosis factor receptor I (TNFRSF1A) and receptor II (TNFRSF1B) genes are associated with the anemia observed in rheumatoid arthritis (RA). METHODS: We studied a group of Caucasian patients (n = 160) with established RA on whom longitudinal data of hemoglobin (Hb) levels over 5 years were recorded. A second group of patients (n = 102) with early RA was used for a confirmation study. Polymerase chain reaction restriction fragment length polymorphism analysis was used to genotype patients for the A36G polymorphism in the TNFRSF1A gene, and the T676G polymorphism in TNFRSF1B. Serum levels of ferritin were determined by ELISA and used to differentiate between iron deficiency anemia (IDA) and anemia of chronic disease (ACD). Data were analyzed by Kruskal-Wallis analysis of variance and logistic regression analysis. RESULTS: The TNFRSF1A GG genotype was associated with lower 5-year mean area under the curve Hb levels compared with other genotypes (p = 0.01). Analysis of anemic status showed an increased frequency of anemia in patients carrying a G allele, with the highest frequency in GG homozygotes. The TNFRSF1A GG genotype was significantly associated with IDA in established RA (OR 4.3, p = 0.01), and this was confirmed in a group of patients with early RA (OR 4.8, p = 0.04). Analysis of the combined groups also showed a weak association of the G allele with ACD (OR 2.2, p = 0.04). No association was found between TNFRSF1B variants and anemia when the cohorts were analyzed separately, but an association between carriage of the T allele and ACD was found when the 2 groups were combined (OR 11.5, p = 0.01). CONCLUSION: Our data suggest that polymorphisms within the TNFRSF1A and TNFRSF1B genes are associated with IDA and/or ACD in patients with RA. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/16142859/Anemia_in_rheumatoid_arthritis:_association_with_polymorphism_in_the_tumor_necrosis_factor_receptor_I_and_II_genes_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=16142859 DB - PRIME DP - Unbound Medicine ER -