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Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Clin Cancer Res. 2005 Sep 01; 11(17):6116-26.CC

Abstract

PURPOSE

Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine. This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers with that in the normal tissues that they resemble.

EXPERIMENTAL DESIGN

Expression of 63,000 probe sets was measured in 50 ovarian cancers, in 5 pools of normal ovarian epithelial brushings, and in mucosal scrapings from 4 normal fallopian tube, 5 endometrium, and 4 colon specimens. Using rank-sum analysis, genes whose expressions best differentiated the ovarian cancer histotypes and normal ovarian epithelium were used to determine whether a correlation based on gene expression existed between ovarian cancer histotypes and the normal tissues they resemble.

RESULTS

When compared with normal ovarian epithelial brushings, alterations in serous tumors correlated with those in normal fallopian tube (P = 0.0042) but not in other normal tissues. Similarly, mucinous cancers correlated with those in normal colonic mucosa (P = 0.0003), and both endometrioid and clear cell histotypes correlated with changes in normal endometrium (P = 0.0172 and 0.0002, respectively). Mucinous cancers displayed the greatest number of alterations in gene expression when compared with normal ovarian epithelial cells.

CONCLUSION

Studies at a molecular level show distinct expression profiles of different histologies of ovarian cancer and support the long-held belief that histotypes of ovarian cancers come to resemble normal fallopian tube, endometrial, and colonic epithelium. Several potential molecular markers for mucinous ovarian cancers have been identified.

Authors+Show Affiliations

Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. rtmarquez@mdanderson.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16144910

Citation

Marquez, Rebecca T., et al. "Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate With Those in Normal Fallopian Tube, Endometrium, and Colon." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 11, no. 17, 2005, pp. 6116-26.
Marquez RT, Baggerly KA, Patterson AP, et al. Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res. 2005;11(17):6116-26.
Marquez, R. T., Baggerly, K. A., Patterson, A. P., Liu, J., Broaddus, R., Frumovitz, M., Atkinson, E. N., Smith, D. I., Hartmann, L., Fishman, D., Berchuck, A., Whitaker, R., Gershenson, D. M., Mills, G. B., Bast, R. C., & Lu, K. H. (2005). Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 11(17), 6116-26.
Marquez RT, et al. Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate With Those in Normal Fallopian Tube, Endometrium, and Colon. Clin Cancer Res. 2005 Sep 1;11(17):6116-26. PubMed PMID: 16144910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. AU - Marquez,Rebecca T, AU - Baggerly,Keith A, AU - Patterson,Andrea P, AU - Liu,Jinsong, AU - Broaddus,Russell, AU - Frumovitz,Michael, AU - Atkinson,Edward N, AU - Smith,David I, AU - Hartmann,Lynn, AU - Fishman,David, AU - Berchuck,Andrew, AU - Whitaker,Regina, AU - Gershenson,David M, AU - Mills,Gordon B, AU - Bast,Robert C,Jr AU - Lu,Karen H, PY - 2005/9/8/pubmed PY - 2005/11/3/medline PY - 2005/9/8/entrez SP - 6116 EP - 26 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 11 IS - 17 N2 - PURPOSE: Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine. This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers with that in the normal tissues that they resemble. EXPERIMENTAL DESIGN: Expression of 63,000 probe sets was measured in 50 ovarian cancers, in 5 pools of normal ovarian epithelial brushings, and in mucosal scrapings from 4 normal fallopian tube, 5 endometrium, and 4 colon specimens. Using rank-sum analysis, genes whose expressions best differentiated the ovarian cancer histotypes and normal ovarian epithelium were used to determine whether a correlation based on gene expression existed between ovarian cancer histotypes and the normal tissues they resemble. RESULTS: When compared with normal ovarian epithelial brushings, alterations in serous tumors correlated with those in normal fallopian tube (P = 0.0042) but not in other normal tissues. Similarly, mucinous cancers correlated with those in normal colonic mucosa (P = 0.0003), and both endometrioid and clear cell histotypes correlated with changes in normal endometrium (P = 0.0172 and 0.0002, respectively). Mucinous cancers displayed the greatest number of alterations in gene expression when compared with normal ovarian epithelial cells. CONCLUSION: Studies at a molecular level show distinct expression profiles of different histologies of ovarian cancer and support the long-held belief that histotypes of ovarian cancers come to resemble normal fallopian tube, endometrial, and colonic epithelium. Several potential molecular markers for mucinous ovarian cancers have been identified. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/16144910/Patterns_of_gene_expression_in_different_histotypes_of_epithelial_ovarian_cancer_correlate_with_those_in_normal_fallopian_tube_endometrium_and_colon_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16144910 DB - PRIME DP - Unbound Medicine ER -