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Genital lesions associated with visceral leishmaniasis and shedding of Leishmania sp. in the semen of naturally infected dogs.
Vet Pathol 2005; 42(5):650-8VP

Abstract

Although visceral leishmaniasis is primarily transmitted by a biological invertebrate vector, transmission in the absence of the vector has been reported, including venereal transmission in humans. Considering the possibility of venereal transmission, we studied genital lesions in dogs naturally infected with visceral leishmaniasis and shedding of Leishmania sp. in the semen. Approximately 200 dogs were serologically tested for anti-Leishmania antibodies and divided into three groups: 1) serologically negative dogs (n = 20), 2) asymptomatic serologically positive dogs (n = 20), and 3) symptomatic serologically positive dogs (n = 20). Samples from both testes, all segments of both epididymes, prostate gland, glans penis, and prepuce were histologically evaluated and processed for immunodetection of Leishmania sp. Semen samples were obtained from 22 symptomatic serologically positive dogs and processed for detecting Leishmania DNA by polymerase chain reaction. A significantly higher frequency of inflammation was observed in the epididymes, glans penis, and prepuce of dogs with visceral leishmaniasis, which was associated with a high frequency of immunohistochemically positive tissues (up to 95% of tissues from symptomatic dogs were positive by immunohistochemistry). Leishmania DNA was detected in eight of 22 semen samples from symptomatic dogs. Together these findings indicate that genital lesions and shedding of Leishmania sp. (donovani complex) in the semen are associated with visceral leishmaniasis. Additional studies should address the possibility of venereal transmission of the disease in the dog.

Authors+Show Affiliations

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária da Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16145211

Citation

Diniz, S A., et al. "Genital Lesions Associated With Visceral Leishmaniasis and Shedding of Leishmania Sp. in the Semen of Naturally Infected Dogs." Veterinary Pathology, vol. 42, no. 5, 2005, pp. 650-8.
Diniz SA, Melo MS, Borges AM, et al. Genital lesions associated with visceral leishmaniasis and shedding of Leishmania sp. in the semen of naturally infected dogs. Vet Pathol. 2005;42(5):650-8.
Diniz, S. A., Melo, M. S., Borges, A. M., Bueno, R., Reis, B. P., Tafuri, W. L., ... Santos, R. L. (2005). Genital lesions associated with visceral leishmaniasis and shedding of Leishmania sp. in the semen of naturally infected dogs. Veterinary Pathology, 42(5), pp. 650-8.
Diniz SA, et al. Genital Lesions Associated With Visceral Leishmaniasis and Shedding of Leishmania Sp. in the Semen of Naturally Infected Dogs. Vet Pathol. 2005;42(5):650-8. PubMed PMID: 16145211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genital lesions associated with visceral leishmaniasis and shedding of Leishmania sp. in the semen of naturally infected dogs. AU - Diniz,S A, AU - Melo,M S, AU - Borges,A M, AU - Bueno,R, AU - Reis,B P, AU - Tafuri,W L, AU - Nascimento,E F, AU - Santos,R L, PY - 2005/9/8/pubmed PY - 2005/12/15/medline PY - 2005/9/8/entrez SP - 650 EP - 8 JF - Veterinary pathology JO - Vet. Pathol. VL - 42 IS - 5 N2 - Although visceral leishmaniasis is primarily transmitted by a biological invertebrate vector, transmission in the absence of the vector has been reported, including venereal transmission in humans. Considering the possibility of venereal transmission, we studied genital lesions in dogs naturally infected with visceral leishmaniasis and shedding of Leishmania sp. in the semen. Approximately 200 dogs were serologically tested for anti-Leishmania antibodies and divided into three groups: 1) serologically negative dogs (n = 20), 2) asymptomatic serologically positive dogs (n = 20), and 3) symptomatic serologically positive dogs (n = 20). Samples from both testes, all segments of both epididymes, prostate gland, glans penis, and prepuce were histologically evaluated and processed for immunodetection of Leishmania sp. Semen samples were obtained from 22 symptomatic serologically positive dogs and processed for detecting Leishmania DNA by polymerase chain reaction. A significantly higher frequency of inflammation was observed in the epididymes, glans penis, and prepuce of dogs with visceral leishmaniasis, which was associated with a high frequency of immunohistochemically positive tissues (up to 95% of tissues from symptomatic dogs were positive by immunohistochemistry). Leishmania DNA was detected in eight of 22 semen samples from symptomatic dogs. Together these findings indicate that genital lesions and shedding of Leishmania sp. (donovani complex) in the semen are associated with visceral leishmaniasis. Additional studies should address the possibility of venereal transmission of the disease in the dog. SN - 0300-9858 UR - https://www.unboundmedicine.com/medline/citation/16145211/Genital_lesions_associated_with_visceral_leishmaniasis_and_shedding_of_Leishmania_sp__in_the_semen_of_naturally_infected_dogs_ L2 - http://journals.sagepub.com/doi/full/10.1354/vp.42-5-650?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -