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The relationship between obesity and race on inhibin B during the menopause transition.
Menopause. 2005 Sep-Oct; 12(5):559-66.M

Abstract

OBJECTIVE

Data are lacking on the effects of obesity and race on inhibin B levels during the menopause transition. The purpose of this study was to determine the relationship among inhibin B levels, body mass index (BMI), and race during the menopause transition.

DESIGN

In the Penn Ovarian Aging Study, a prospective cohort study of reproductive aging, 436 women aged 35 to 47 years were followed up with serial hormones, anthropometric measures, and questionnaires for 6 years. Univariate and multivariable analyses were performed comparing mean log transformed inhibin B levels among menopause stages, age groups, BMI categories, races, and smoking groups.

RESULTS

In the univariate analyses, mean inhibin B levels were negatively associated with menopause stage, age, and BMI, but not significantly with race or smoking. Interactions of menopause status and BMI were significant (P < 0.001). Premenopausal women with a BMI of 25 or higher had significantly lower inhibin B levels compared with women with a BMI of less than 25 (41.8 pg/mL vs 58.4 pg/mL, P < 0.001), whereas postmenopausal women with a BMI of 30 or higher had significantly higher inhibin B levels compared with the postmenopausal women with a BMI of less than 25 (29.1 pg/mL vs 26.7 pg/mL, P < 0.001).

CONCLUSIONS

Although BMI is a significant independent predictor of inhibin B levels, the relationship between BMI and inhibin B changes with advancing menopause stage. These data provide additional evidence that obesity influences hormones during the menopause transition.

Authors+Show Affiliations

Department of Obstetrics/Gynecology , University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. cgarcia@obgyn.upenn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16145310

Citation

Gracia, Clarisa R., et al. "The Relationship Between Obesity and Race On Inhibin B During the Menopause Transition." Menopause (New York, N.Y.), vol. 12, no. 5, 2005, pp. 559-66.
Gracia CR, Freeman EW, Sammel MD, et al. The relationship between obesity and race on inhibin B during the menopause transition. Menopause. 2005;12(5):559-66.
Gracia, C. R., Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2005). The relationship between obesity and race on inhibin B during the menopause transition. Menopause (New York, N.Y.), 12(5), 559-66.
Gracia CR, et al. The Relationship Between Obesity and Race On Inhibin B During the Menopause Transition. Menopause. 2005 Sep-Oct;12(5):559-66. PubMed PMID: 16145310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between obesity and race on inhibin B during the menopause transition. AU - Gracia,Clarisa R, AU - Freeman,Ellen W, AU - Sammel,Mary D, AU - Lin,Hui, AU - Nelson,Deborah B, Y1 - 2005/09/01/ PY - 2005/9/8/pubmed PY - 2006/2/8/medline PY - 2005/9/8/entrez SP - 559 EP - 66 JF - Menopause (New York, N.Y.) JO - Menopause VL - 12 IS - 5 N2 - OBJECTIVE: Data are lacking on the effects of obesity and race on inhibin B levels during the menopause transition. The purpose of this study was to determine the relationship among inhibin B levels, body mass index (BMI), and race during the menopause transition. DESIGN: In the Penn Ovarian Aging Study, a prospective cohort study of reproductive aging, 436 women aged 35 to 47 years were followed up with serial hormones, anthropometric measures, and questionnaires for 6 years. Univariate and multivariable analyses were performed comparing mean log transformed inhibin B levels among menopause stages, age groups, BMI categories, races, and smoking groups. RESULTS: In the univariate analyses, mean inhibin B levels were negatively associated with menopause stage, age, and BMI, but not significantly with race or smoking. Interactions of menopause status and BMI were significant (P < 0.001). Premenopausal women with a BMI of 25 or higher had significantly lower inhibin B levels compared with women with a BMI of less than 25 (41.8 pg/mL vs 58.4 pg/mL, P < 0.001), whereas postmenopausal women with a BMI of 30 or higher had significantly higher inhibin B levels compared with the postmenopausal women with a BMI of less than 25 (29.1 pg/mL vs 26.7 pg/mL, P < 0.001). CONCLUSIONS: Although BMI is a significant independent predictor of inhibin B levels, the relationship between BMI and inhibin B changes with advancing menopause stage. These data provide additional evidence that obesity influences hormones during the menopause transition. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/16145310/The_relationship_between_obesity_and_race_on_inhibin_B_during_the_menopause_transition_ L2 - https://doi.org/10.1097/01.gme.0000172268.24949.94 DB - PRIME DP - Unbound Medicine ER -