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Soluble transferrin receptor and zinc protoporphyrin--competitors or efficient partners?
Eur J Haematol 2005; 75(4):309-17EJ

Abstract

OBJECTIVES

Soluble transferrin receptor (sTfR) and zinc protoporphyrin (ZPP) are both parameters of iron deficient erythropoiesis (IDE), the sTfR measurement is commonly regarded to be the more sensitive test. sTfR also reflects erythropoietic activity, it is increased in enhanced erythropoiesis.

METHODS

We investigated the diagnostic accuracy of sTfR in assessment of iron deficiency (ID) and compared it with ZPP. The study was performed on 174 subjects, in which ID has been precisely staged.

RESULTS

Individuals without ID and patients with storage iron depletion only, had normal sTfR values. Patients classified as IDE and patients with iron deficiency anemia had significantly increased sTfR. There was a good correlation between sTfR and hemoglobin (r = -0.86; P < 0.0001) and between sTfR and ZPP (r = 0.86; P < 0.0001). When diagnosing ID, ZPP was the more sensitive test. In mildly developed IDE associated with ZPP-ratios between 40 and 70 micromol/mol heme, the sTfR concentration was elevated in only 25% of the cases. Reliably elevated sTfR values were observed only in more advanced IDE, associated with ZPP > 70 mumol/mol heme.

CONCLUSIONS

ZPP is not inferior to sTfR when diagnosing IDE. Given the good correlation between sTfR and ZPP and because ZPP is uninfluenced by the erythropoietic activity, sTfR and ZPP are not competitors, rather efficient partners in diagnosing anemias. By measuring ZPP and sTfR simultaneously, the diagnostic uncertainty inherent in each of them individually can be eliminated. In particular, the simultaneous determination of ZPP and sTfR enhances the diagnostic power of sTfR in assessment of the erythropoietic activity.

Authors+Show Affiliations

III. Medizinische Universitätsklinik Mannheim, University of Heidelberg, Wiesbadenerstrasse 7-11, 68305 Mannheim, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

16146537

Citation

Metzgeroth, Georgia, et al. "Soluble Transferrin Receptor and Zinc Protoporphyrin--competitors or Efficient Partners?" European Journal of Haematology, vol. 75, no. 4, 2005, pp. 309-17.
Metzgeroth G, Adelberger V, Dorn-Beineke A, et al. Soluble transferrin receptor and zinc protoporphyrin--competitors or efficient partners? Eur J Haematol. 2005;75(4):309-17.
Metzgeroth, G., Adelberger, V., Dorn-Beineke, A., Kuhn, C., Schatz, M., Maywald, O., ... Hastka, J. (2005). Soluble transferrin receptor and zinc protoporphyrin--competitors or efficient partners? European Journal of Haematology, 75(4), pp. 309-17.
Metzgeroth G, et al. Soluble Transferrin Receptor and Zinc Protoporphyrin--competitors or Efficient Partners. Eur J Haematol. 2005;75(4):309-17. PubMed PMID: 16146537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble transferrin receptor and zinc protoporphyrin--competitors or efficient partners? AU - Metzgeroth,Georgia, AU - Adelberger,Verena, AU - Dorn-Beineke,Alexandra, AU - Kuhn,Christian, AU - Schatz,Michael, AU - Maywald,Ole, AU - Bertsch,Thomas, AU - Wisser,Hermann, AU - Hehlmann,Rüdiger, AU - Hastka,Jan, PY - 2005/9/9/pubmed PY - 2005/10/19/medline PY - 2005/9/9/entrez SP - 309 EP - 17 JF - European journal of haematology JO - Eur. J. Haematol. VL - 75 IS - 4 N2 - OBJECTIVES: Soluble transferrin receptor (sTfR) and zinc protoporphyrin (ZPP) are both parameters of iron deficient erythropoiesis (IDE), the sTfR measurement is commonly regarded to be the more sensitive test. sTfR also reflects erythropoietic activity, it is increased in enhanced erythropoiesis. METHODS: We investigated the diagnostic accuracy of sTfR in assessment of iron deficiency (ID) and compared it with ZPP. The study was performed on 174 subjects, in which ID has been precisely staged. RESULTS: Individuals without ID and patients with storage iron depletion only, had normal sTfR values. Patients classified as IDE and patients with iron deficiency anemia had significantly increased sTfR. There was a good correlation between sTfR and hemoglobin (r = -0.86; P < 0.0001) and between sTfR and ZPP (r = 0.86; P < 0.0001). When diagnosing ID, ZPP was the more sensitive test. In mildly developed IDE associated with ZPP-ratios between 40 and 70 micromol/mol heme, the sTfR concentration was elevated in only 25% of the cases. Reliably elevated sTfR values were observed only in more advanced IDE, associated with ZPP > 70 mumol/mol heme. CONCLUSIONS: ZPP is not inferior to sTfR when diagnosing IDE. Given the good correlation between sTfR and ZPP and because ZPP is uninfluenced by the erythropoietic activity, sTfR and ZPP are not competitors, rather efficient partners in diagnosing anemias. By measuring ZPP and sTfR simultaneously, the diagnostic uncertainty inherent in each of them individually can be eliminated. In particular, the simultaneous determination of ZPP and sTfR enhances the diagnostic power of sTfR in assessment of the erythropoietic activity. SN - 0902-4441 UR - https://www.unboundmedicine.com/medline/citation/16146537/Soluble_transferrin_receptor_and_zinc_protoporphyrin__competitors_or_efficient_partners L2 - https://doi.org/10.1111/j.1600-0609.2005.00515.x DB - PRIME DP - Unbound Medicine ER -