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[Experimental study of effect of carvedilol on myocardial collagen network remodeling after acute myocardial infarction in rats].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Sep; 17(9):537-40.ZW

Abstract

OBJECTIVE

To investigate the effects of carvedilol, irbesartan and their combination on myocardial collagen network remodeling after acute myocardial infarction (AMI) in rats.

METHODS

Twenty-four hours after ligating left anterior descending coronary artery, 35 surviving AMI male Sprague-Dawley rats were randomly assigned to control (n=8), carvedilol (n=9, 10 mg.kg(-1).d(-1)), irbesartan (n=9, 45 mg.kg(-1).d(-1)), and carvedilol (10 mg.kg(-1).d(-1)) plus irbesartan (45 mg.kg(-1).d(-1), n=9) groups. Sham operating group was comprised of 8 rats without coronary artery ligation as controls. After 8 weeks of administration of the drug by gastric gavage, hemodynamics and left ventricular function were measured, then the rat hearts were fixed, sectioned, and stained with Sirius red, and pathologically analyzed using polarized light. The total collagen volume density fraction (CVF) and type I and III CVF in the infarcted and noninfarcted zone (IZ/NIZ) were measured by computer-assisted image analysis system.

RESULTS

There were no significant differences in myocardial infarction size among the four AMI groups (40.02%-44.70%, P>0.05). Compared with the sham operation group, left ventricular (LV) end diastolic pressure (LVEDP), left and right ventricular relative weight (LVRW/RVRW), the total CVF and the CVF of type I and III in the IZ and NIZ were all significantly higher (P<0.05 or P<0.01), and in contrast, blood pressure, left ventricular systolic pressure (LVSP), the left ventricular pressure maximal rate of rise and fall (+/-dp/dt max) and their adjustment by LVSP (+/-dp/dt max/LVSP) were significantly decreased (P<0.05 or P<0.01). Compared with the control group, LVEDP, LVRW, RVRW, the total CVF and the CVF of type I and III in the NIZ were all significantly decreased (P<0.05 or P<0.01), while +/-dp/dt max and +/-dp/dt max/LVSP were all significantly increased (all P<0.01) in the carvedilol, irbesartan and their combination therapy groups.

CONCLUSION

Carvedilol, irbesartan and their combination can all effectively decrease collagen deposition in the NIZ of left ventricle, prevent left ventricular remodeling after AMI in rats, improve hemodynamics and LV function.

Authors+Show Affiliations

Department of Cardiological Laboratory, General Hospital of PLA, Beijing 100853, China. liuhbin301@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16146598

Citation

Liu, Hong-bin, et al. "[Experimental Study of Effect of Carvedilol On Myocardial Collagen Network Remodeling After Acute Myocardial Infarction in Rats]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 17, no. 9, 2005, pp. 537-40.
Liu HB, Bian SY, Yang TS, et al. [Experimental study of effect of carvedilol on myocardial collagen network remodeling after acute myocardial infarction in rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17(9):537-40.
Liu, H. B., Bian, S. Y., Yang, T. S., Wang, L., Yi, J., & Yang, X. (2005). [Experimental study of effect of carvedilol on myocardial collagen network remodeling after acute myocardial infarction in rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 17(9), 537-40.
Liu HB, et al. [Experimental Study of Effect of Carvedilol On Myocardial Collagen Network Remodeling After Acute Myocardial Infarction in Rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17(9):537-40. PubMed PMID: 16146598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Experimental study of effect of carvedilol on myocardial collagen network remodeling after acute myocardial infarction in rats]. AU - Liu,Hong-bin, AU - Bian,Su-yan, AU - Yang,Ting-Shu, AU - Wang,Li, AU - Yi,Jun, AU - Yang,Xia, PY - 2005/9/9/pubmed PY - 2009/8/8/medline PY - 2005/9/9/entrez SP - 537 EP - 40 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 17 IS - 9 N2 - OBJECTIVE: To investigate the effects of carvedilol, irbesartan and their combination on myocardial collagen network remodeling after acute myocardial infarction (AMI) in rats. METHODS: Twenty-four hours after ligating left anterior descending coronary artery, 35 surviving AMI male Sprague-Dawley rats were randomly assigned to control (n=8), carvedilol (n=9, 10 mg.kg(-1).d(-1)), irbesartan (n=9, 45 mg.kg(-1).d(-1)), and carvedilol (10 mg.kg(-1).d(-1)) plus irbesartan (45 mg.kg(-1).d(-1), n=9) groups. Sham operating group was comprised of 8 rats without coronary artery ligation as controls. After 8 weeks of administration of the drug by gastric gavage, hemodynamics and left ventricular function were measured, then the rat hearts were fixed, sectioned, and stained with Sirius red, and pathologically analyzed using polarized light. The total collagen volume density fraction (CVF) and type I and III CVF in the infarcted and noninfarcted zone (IZ/NIZ) were measured by computer-assisted image analysis system. RESULTS: There were no significant differences in myocardial infarction size among the four AMI groups (40.02%-44.70%, P>0.05). Compared with the sham operation group, left ventricular (LV) end diastolic pressure (LVEDP), left and right ventricular relative weight (LVRW/RVRW), the total CVF and the CVF of type I and III in the IZ and NIZ were all significantly higher (P<0.05 or P<0.01), and in contrast, blood pressure, left ventricular systolic pressure (LVSP), the left ventricular pressure maximal rate of rise and fall (+/-dp/dt max) and their adjustment by LVSP (+/-dp/dt max/LVSP) were significantly decreased (P<0.05 or P<0.01). Compared with the control group, LVEDP, LVRW, RVRW, the total CVF and the CVF of type I and III in the NIZ were all significantly decreased (P<0.05 or P<0.01), while +/-dp/dt max and +/-dp/dt max/LVSP were all significantly increased (all P<0.01) in the carvedilol, irbesartan and their combination therapy groups. CONCLUSION: Carvedilol, irbesartan and their combination can all effectively decrease collagen deposition in the NIZ of left ventricle, prevent left ventricular remodeling after AMI in rats, improve hemodynamics and LV function. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/16146598/[Experimental_study_of_effect_of_carvedilol_on_myocardial_collagen_network_remodeling_after_acute_myocardial_infarction_in_rats]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -