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Simultaneous human papillomavirus 6 (HPV 6) -positive condyloma acuminatum, HPV 31-positive Bowen's disease, and non HPV-associated extramammary Paget's disease coexisting within an area presenting clinically as condyloma acuminatum.
Am J Dermatopathol 2005; 27(5):439-42AJ

Abstract

An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. Histologically, there were three distinct epithelial changes compatible with condyloma acuminatum, Bowen's disease, and extramammary Paget's disease (EMPD). By in situ hybridization, the zone of condyloma acuminatum was positive for HPV 6 and well demarcated from HPV 31-positive Bowen's disease. EMPD was negative for targeted HPV 6/11/16/18/31/33 probes. Immunohistochemically, Paget's cells expressing cytokeratin 7 were distributed as scattered single cells or clusters mainly in the lower part of the HPV 6/31-positive epithelium. To the best of our knowledge, this is the first reported case of the occurrence of condyloma acuminatum, Bowen's disease, and EMPD within the same lesion.

Authors+Show Affiliations

Department of Dermatology, Kumamoto University School of Medicine, Kumamoto, Japan. kuroibo@kaiju.medic.kumamoto-u.ac.jpNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16148417

Citation

Egawa, Kiyofumi, and Yumi Honda. "Simultaneous Human Papillomavirus 6 (HPV 6) -positive Condyloma Acuminatum, HPV 31-positive Bowen's Disease, and Non HPV-associated Extramammary Paget's Disease Coexisting Within an Area Presenting Clinically as Condyloma Acuminatum." The American Journal of Dermatopathology, vol. 27, no. 5, 2005, pp. 439-42.
Egawa K, Honda Y. Simultaneous human papillomavirus 6 (HPV 6) -positive condyloma acuminatum, HPV 31-positive Bowen's disease, and non HPV-associated extramammary Paget's disease coexisting within an area presenting clinically as condyloma acuminatum. Am J Dermatopathol. 2005;27(5):439-42.
Egawa, K., & Honda, Y. (2005). Simultaneous human papillomavirus 6 (HPV 6) -positive condyloma acuminatum, HPV 31-positive Bowen's disease, and non HPV-associated extramammary Paget's disease coexisting within an area presenting clinically as condyloma acuminatum. The American Journal of Dermatopathology, 27(5), pp. 439-42.
Egawa K, Honda Y. Simultaneous Human Papillomavirus 6 (HPV 6) -positive Condyloma Acuminatum, HPV 31-positive Bowen's Disease, and Non HPV-associated Extramammary Paget's Disease Coexisting Within an Area Presenting Clinically as Condyloma Acuminatum. Am J Dermatopathol. 2005;27(5):439-42. PubMed PMID: 16148417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous human papillomavirus 6 (HPV 6) -positive condyloma acuminatum, HPV 31-positive Bowen's disease, and non HPV-associated extramammary Paget's disease coexisting within an area presenting clinically as condyloma acuminatum. AU - Egawa,Kiyofumi, AU - Honda,Yumi, PY - 2005/9/9/pubmed PY - 2005/12/21/medline PY - 2005/9/9/entrez SP - 439 EP - 42 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 27 IS - 5 N2 - An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. Histologically, there were three distinct epithelial changes compatible with condyloma acuminatum, Bowen's disease, and extramammary Paget's disease (EMPD). By in situ hybridization, the zone of condyloma acuminatum was positive for HPV 6 and well demarcated from HPV 31-positive Bowen's disease. EMPD was negative for targeted HPV 6/11/16/18/31/33 probes. Immunohistochemically, Paget's cells expressing cytokeratin 7 were distributed as scattered single cells or clusters mainly in the lower part of the HPV 6/31-positive epithelium. To the best of our knowledge, this is the first reported case of the occurrence of condyloma acuminatum, Bowen's disease, and EMPD within the same lesion. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/16148417/Simultaneous_human_papillomavirus_6__HPV_6___positive_condyloma_acuminatum_HPV_31_positive_Bowen's_disease_and_non_HPV_associated_extramammary_Paget's_disease_coexisting_within_an_area_presenting_clinically_as_condyloma_acuminatum_ L2 - http://dx.doi.org/10.1097/01.dad.0000157463.57087.6a DB - PRIME DP - Unbound Medicine ER -