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Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids.
Behav Pharmacol 2005; 16(5-6):487-96BP

Abstract

This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy marijuana users (12 men, 11 women) participated in four sessions. They were randomly assigned to a low or a high delta9-tetrahydrocannabinol group (THC; 1.8% versus 3.6%). In the four sessions under blinded conditions subjects smoked marijuana cigarettes containing placebo (no active cannabinoids), or cigarettes containing THC with low or high levels of cannabichromene (CBC; 0.1% versus 0.5%) and low or high levels of cannabidiol (CBD; 0.2% versus 1.0%). Dependent measures included subjective reports, measures of cognitive task performance and neurophysiological measures [electroencephalographic (EEG) and event-related potential (ERP)]. Compared to placebo, active THC cigarettes produced expected effects on mood, behavior and brain activity. A decrease in performance, reduction in EEG power and attenuation of ERP components reflecting attentional processes were observed during tests of working memory and episodic memory. Most of these effects were not dose-dependent. Varying the concentrations of CBC and CBD did not change subjects' responses on any of the outcome measures. These findings are consistent with previous studies indicating that THC and its metabolites are the primary active constituents of marijuana. They also suggest that neurophysiological EEG and ERP measures are useful biomarkers of the effects of THC.

Authors+Show Affiliations

The San Francisco Brain Research Institute and SAM Technology, CA 94108, USA. aaron@eeg.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16148455

Citation

Ilan, A B., et al. "Neurophysiological and Subjective Profile of Marijuana With Varying Concentrations of Cannabinoids." Behavioural Pharmacology, vol. 16, no. 5-6, 2005, pp. 487-96.
Ilan AB, Gevins A, Coleman M, et al. Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Behav Pharmacol. 2005;16(5-6):487-96.
Ilan, A. B., Gevins, A., Coleman, M., ElSohly, M. A., & de Wit, H. (2005). Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Behavioural Pharmacology, 16(5-6), pp. 487-96.
Ilan AB, et al. Neurophysiological and Subjective Profile of Marijuana With Varying Concentrations of Cannabinoids. Behav Pharmacol. 2005;16(5-6):487-96. PubMed PMID: 16148455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. AU - Ilan,A B, AU - Gevins,A, AU - Coleman,M, AU - ElSohly,M A, AU - de Wit,H, PY - 2005/9/9/pubmed PY - 2006/1/10/medline PY - 2005/9/9/entrez SP - 487 EP - 96 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 16 IS - 5-6 N2 - This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy marijuana users (12 men, 11 women) participated in four sessions. They were randomly assigned to a low or a high delta9-tetrahydrocannabinol group (THC; 1.8% versus 3.6%). In the four sessions under blinded conditions subjects smoked marijuana cigarettes containing placebo (no active cannabinoids), or cigarettes containing THC with low or high levels of cannabichromene (CBC; 0.1% versus 0.5%) and low or high levels of cannabidiol (CBD; 0.2% versus 1.0%). Dependent measures included subjective reports, measures of cognitive task performance and neurophysiological measures [electroencephalographic (EEG) and event-related potential (ERP)]. Compared to placebo, active THC cigarettes produced expected effects on mood, behavior and brain activity. A decrease in performance, reduction in EEG power and attenuation of ERP components reflecting attentional processes were observed during tests of working memory and episodic memory. Most of these effects were not dose-dependent. Varying the concentrations of CBC and CBD did not change subjects' responses on any of the outcome measures. These findings are consistent with previous studies indicating that THC and its metabolites are the primary active constituents of marijuana. They also suggest that neurophysiological EEG and ERP measures are useful biomarkers of the effects of THC. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/16148455/Neurophysiological_and_subjective_profile_of_marijuana_with_varying_concentrations_of_cannabinoids_ L2 - http://Insights.ovid.com/pubmed?pmid=16148455 DB - PRIME DP - Unbound Medicine ER -