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Effects of probiotics on the gastrointestinal tract.
Curr Opin Infect Dis 2005; 18(5):420-6CO

Abstract

PURPOSE OF REVIEW

This review summarizes recent developments in our understanding of what gastrointestinal disorders probiotics can be of benefit for, focussing on conditions associated with infection or disruption of the normal gut flora. New insights into the effects administered strains can have in the gut, their safety, and potential for future development, will also be discussed.

RECENT FINDINGS

Recent clinical studies have shown that probiotics can protect young children from diarrhoeal illness, including antibiotic-associated diarrhoea. They may also protect neonates from necrotizing enterocolitis. In adults, they can help prevent or reduce the severity of diarrhoeal illness, and ameliorate side-effects for those undergoing antibiotic therapy for infection. Researchers are looking at combining probiotics with prebiotics to enhance anti-inflammatory effects and restore colonization resistance of the commensal flora. New technologies are elucidating complex effects on gene expression in the gut, the probiotic, and bacterial pathogens. Recombinant strains capable of binding bacterial toxins are being developed as novel therapeutics against gastrointestinal infection.

SUMMARY

Considering the clinical trial evidence of therapeutic benefit, probiotics are an underused treatment modality for prevention and amelioration of diarrhoeal illness. Better understanding of strain-specific effects, dosing regimens and any contraindications should help resolve this.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK. A.M.Snelling@Bradford.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16148529

Citation

Snelling, Anna M.. "Effects of Probiotics On the Gastrointestinal Tract." Current Opinion in Infectious Diseases, vol. 18, no. 5, 2005, pp. 420-6.
Snelling AM. Effects of probiotics on the gastrointestinal tract. Curr Opin Infect Dis. 2005;18(5):420-6.
Snelling, A. M. (2005). Effects of probiotics on the gastrointestinal tract. Current Opinion in Infectious Diseases, 18(5), pp. 420-6.
Snelling AM. Effects of Probiotics On the Gastrointestinal Tract. Curr Opin Infect Dis. 2005;18(5):420-6. PubMed PMID: 16148529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of probiotics on the gastrointestinal tract. A1 - Snelling,Anna M, PY - 2005/9/9/pubmed PY - 2005/11/10/medline PY - 2005/9/9/entrez SP - 420 EP - 6 JF - Current opinion in infectious diseases JO - Curr. Opin. Infect. Dis. VL - 18 IS - 5 N2 - PURPOSE OF REVIEW: This review summarizes recent developments in our understanding of what gastrointestinal disorders probiotics can be of benefit for, focussing on conditions associated with infection or disruption of the normal gut flora. New insights into the effects administered strains can have in the gut, their safety, and potential for future development, will also be discussed. RECENT FINDINGS: Recent clinical studies have shown that probiotics can protect young children from diarrhoeal illness, including antibiotic-associated diarrhoea. They may also protect neonates from necrotizing enterocolitis. In adults, they can help prevent or reduce the severity of diarrhoeal illness, and ameliorate side-effects for those undergoing antibiotic therapy for infection. Researchers are looking at combining probiotics with prebiotics to enhance anti-inflammatory effects and restore colonization resistance of the commensal flora. New technologies are elucidating complex effects on gene expression in the gut, the probiotic, and bacterial pathogens. Recombinant strains capable of binding bacterial toxins are being developed as novel therapeutics against gastrointestinal infection. SUMMARY: Considering the clinical trial evidence of therapeutic benefit, probiotics are an underused treatment modality for prevention and amelioration of diarrhoeal illness. Better understanding of strain-specific effects, dosing regimens and any contraindications should help resolve this. SN - 0951-7375 UR - https://www.unboundmedicine.com/medline/citation/16148529/Effects_of_probiotics_on_the_gastrointestinal_tract_ L2 - http://dx.doi.org/10.1097/01.qco.0000182103.32504.e3 DB - PRIME DP - Unbound Medicine ER -