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Acute ophthalmoplegia and nystagmus in infants fed a thiamine-deficient formula: an epidemic of Wernicke encephalopathy.
J Neuroophthalmol. 2005 Sep; 25(3):169-72.JN

Abstract

In 2003, an epidemic of Wernicke encephalopathy (WE) developed in Israeli infants fed a thiamine-deficient soy-based formula. Approximately 20 infants were affected out of an estimated 3500 fed the vitamin-deficient formula. The finding of gaze abnormalities in a single infant by neuro-ophthalmologists led to the unraveling of the epidemic. In this report, the findings in three infants are described. Early diagnosis and treatment with parenteral thiamine led to complete neurologic recovery in two infants; in the third infant, delayed diagnosis may have been responsible for severe lingering deficits. This is the first reported epidemic of WE secondary to thiamine-deficient infant formula. Early diagnosis and treatment are critical to avoid persistent neurologic impairment.

Authors+Show Affiliations

Neuro-ophthalmology Unit (AK) and the Department of Ophthalmology (AK,CS), Tel Aviv Medical Center, and the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. kesler@netvision.net.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16148620

Citation

Kesler, Anat, et al. "Acute Ophthalmoplegia and Nystagmus in Infants Fed a Thiamine-deficient Formula: an Epidemic of Wernicke Encephalopathy." Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society, vol. 25, no. 3, 2005, pp. 169-72.
Kesler A, Stolovitch C, Hoffmann C, et al. Acute ophthalmoplegia and nystagmus in infants fed a thiamine-deficient formula: an epidemic of Wernicke encephalopathy. J Neuroophthalmol. 2005;25(3):169-72.
Kesler, A., Stolovitch, C., Hoffmann, C., Avni, I., & Morad, Y. (2005). Acute ophthalmoplegia and nystagmus in infants fed a thiamine-deficient formula: an epidemic of Wernicke encephalopathy. Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society, 25(3), 169-72.
Kesler A, et al. Acute Ophthalmoplegia and Nystagmus in Infants Fed a Thiamine-deficient Formula: an Epidemic of Wernicke Encephalopathy. J Neuroophthalmol. 2005;25(3):169-72. PubMed PMID: 16148620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute ophthalmoplegia and nystagmus in infants fed a thiamine-deficient formula: an epidemic of Wernicke encephalopathy. AU - Kesler,Anat, AU - Stolovitch,Chaim, AU - Hoffmann,Chen, AU - Avni,Isaac, AU - Morad,Yair, PY - 2005/9/9/pubmed PY - 2005/12/13/medline PY - 2005/9/9/entrez SP - 169 EP - 72 JF - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society JO - J Neuroophthalmol VL - 25 IS - 3 N2 - In 2003, an epidemic of Wernicke encephalopathy (WE) developed in Israeli infants fed a thiamine-deficient soy-based formula. Approximately 20 infants were affected out of an estimated 3500 fed the vitamin-deficient formula. The finding of gaze abnormalities in a single infant by neuro-ophthalmologists led to the unraveling of the epidemic. In this report, the findings in three infants are described. Early diagnosis and treatment with parenteral thiamine led to complete neurologic recovery in two infants; in the third infant, delayed diagnosis may have been responsible for severe lingering deficits. This is the first reported epidemic of WE secondary to thiamine-deficient infant formula. Early diagnosis and treatment are critical to avoid persistent neurologic impairment. SN - 1070-8022 UR - https://www.unboundmedicine.com/medline/citation/16148620/Acute_ophthalmoplegia_and_nystagmus_in_infants_fed_a_thiamine_deficient_formula:_an_epidemic_of_Wernicke_encephalopathy_ L2 - https://doi.org/10.1097/01.wno.0000177293.06727.d5 DB - PRIME DP - Unbound Medicine ER -