Tags

Type your tag names separated by a space and hit enter

[The effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report].
Psychiatr Pol. 2005 May-Jun; 39(3):469-79.PP

Abstract

INTRODUCTION AND AIM

Electroconvulsive therapy (ECT) is an effective treatment of severe depression but its mechanism of action is still unknown. The aim of the study was to investigate the effect of first ECT on serum hormone concentrations in patients with severe depression.

MATERIAL AND METHOD

Serum concentrations of prolactin (PRL), adrenocorticotropin (ACTH), thyrotrophin (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), cortisol (F), triiodothyronine (T3), thyroxine (T4), estradiol (E2), progesterone (P) and testosterone (T) were estimated by RIA or IRMA in 5 men (mean age 34.20 +/- 8.70 years) with severe depression. Before ECT, all men were receiving psychotropic medication. None of the patients had clinical symptoms of endocrine disorders. Blood samples for hormonal investigations were taken before and 15 min., 2 hours, 6 h, 12 h, 24 h after the first electroconvulsive shock. The men without endocrine dysfunction in the same range of age who underwent identical intravenous anaesthesia for minor maxillofacial surgery were studied as controls.

RESULTS

Before and after first ECT mean serum LH, T and T3 concentrations were significantly decreased and PRL, F and E mean levels were significantly elevated in men with depression as compared with the control group. No significant changes in mean serum hormone concentrations after ECT as compared to levels before ECT were observed.

CONCLUSION

(1) Single electroconvulsive shock insignificantly changes the pituitary-thyroid-adrenal-gonadal axis function. (2) Complicated hormonal changes found before electroconvulsive shock in patients with severe depression suggest the influence of psychotropic treatment as well as the illness on the endocrine system.

Authors+Show Affiliations

Motta E
Katedra i Klinika Neurologii SAM GCM, Katowicach-Ochojcu.
Ostrowska Z
No affiliation info available
Kazibutowska Z
No affiliation info available
Paluch M
No affiliation info available
Płonka J
No affiliation info available
Gołba A
No affiliation info available

MeSH

Adrenal Cortex HormonesAdrenocorticotropic HormoneAdultCase-Control StudiesDepressive DisorderElectroconvulsive TherapyEstradiolFollicle Stimulating HormoneGonadal Steroid HormonesHumansHydrocortisoneHypothalamo-Hypophyseal SystemLuteinizing HormoneMalePituitary HormonesPituitary-Adrenal SystemProgesteroneProlactinRadioimmunoassayTestosteroneThyrotropinThyroxineTime FactorsTriiodothyronine

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

16149757

Citation

Motta, Ewa, et al. "[The Effect of a Single Electroconvulsive Shock On Pituitary-thyroid-adrenal-gonadal Axis Function in Men With Severe Depression--preliminary Report]." Psychiatria Polska, vol. 39, no. 3, 2005, pp. 469-79.
Motta E, Ostrowska Z, Kazibutowska Z, et al. [The effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report]. Psychiatr Pol. 2005;39(3):469-79.
Motta, E., Ostrowska, Z., Kazibutowska, Z., Paluch, M., Płonka, J., & Gołba, A. (2005). [The effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report]. Psychiatria Polska, 39(3), 469-79.
Motta E, et al. [The Effect of a Single Electroconvulsive Shock On Pituitary-thyroid-adrenal-gonadal Axis Function in Men With Severe Depression--preliminary Report]. Psychiatr Pol. 2005 May-Jun;39(3):469-79. PubMed PMID: 16149757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of a single electroconvulsive shock on pituitary-thyroid-adrenal-gonadal axis function in men with severe depression--preliminary report]. AU - Motta,Ewa, AU - Ostrowska,Zofia, AU - Kazibutowska,Zofia, AU - Paluch,Marek, AU - Płonka,Janusz, AU - Gołba,Anna, PY - 2005/9/10/pubmed PY - 2005/11/4/medline PY - 2005/9/10/entrez SP - 469 EP - 79 JF - Psychiatria polska JO - Psychiatr Pol VL - 39 IS - 3 N2 - INTRODUCTION AND AIM: Electroconvulsive therapy (ECT) is an effective treatment of severe depression but its mechanism of action is still unknown. The aim of the study was to investigate the effect of first ECT on serum hormone concentrations in patients with severe depression. MATERIAL AND METHOD: Serum concentrations of prolactin (PRL), adrenocorticotropin (ACTH), thyrotrophin (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), cortisol (F), triiodothyronine (T3), thyroxine (T4), estradiol (E2), progesterone (P) and testosterone (T) were estimated by RIA or IRMA in 5 men (mean age 34.20 +/- 8.70 years) with severe depression. Before ECT, all men were receiving psychotropic medication. None of the patients had clinical symptoms of endocrine disorders. Blood samples for hormonal investigations were taken before and 15 min., 2 hours, 6 h, 12 h, 24 h after the first electroconvulsive shock. The men without endocrine dysfunction in the same range of age who underwent identical intravenous anaesthesia for minor maxillofacial surgery were studied as controls. RESULTS: Before and after first ECT mean serum LH, T and T3 concentrations were significantly decreased and PRL, F and E mean levels were significantly elevated in men with depression as compared with the control group. No significant changes in mean serum hormone concentrations after ECT as compared to levels before ECT were observed. CONCLUSION: (1) Single electroconvulsive shock insignificantly changes the pituitary-thyroid-adrenal-gonadal axis function. (2) Complicated hormonal changes found before electroconvulsive shock in patients with severe depression suggest the influence of psychotropic treatment as well as the illness on the endocrine system. SN - 0033-2674 UR - https://www.unboundmedicine.com/medline/citation/16149757/[The_effect_of_a_single_electroconvulsive_shock_on_pituitary_thyroid_adrenal_gonadal_axis_function_in_men_with_severe_depression__preliminary_report]_ DB - PRIME DP - Unbound Medicine ER -