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Body mass index and waist circumference in non-alcoholic fatty liver disease.
J Hum Nutr Diet 2005; 18(5):365-70JH

Abstract

OBJECTIVE

To evaluate the association of anthropometric indexes (body mass index and waist circumference) in patients with non-alcoholic fatty liver disease (NAFLD), and its association with insulin resistance (IR), metabolic syndrome (MS) and histological findings.

METHODS

From August 2003 to July 2004 a case series of 81 outpatients with clinic and/or histological diagnosis of NAFLD were selected at the Bahia University Gastro-Hepatology Clinic, Brazil. Liver function tests, lipid profile, glucose and insulin were performed in all patients. Body mass index (BMI) and waist circumference (WC) were determined according to WHO criteria. IR was measured by means of the homeostasis model assessment (HOMA) and IR was considered with HOMA > or =3. MS was defined according to the Adult Treatment Panel III (ATP III). Liver biopsy was performed in 37 cases.

RESULTS

Body mass index > or = 30 kg m(-2) (obesity) was found in 39% of the cases and BMI > or = 25-29.9 kg m(-2) (overweight) in 53%. BMI was correlated with IR (r = 0.29; P = 0.02) and WC with ALT (r = 0.02; P = 0.03). Increased WC also was related to IR and to MS. The presence of steatohepatitis with fibrosis on liver biopsy was associated with overweight (68%) and increase of WC (41%).

CONCLUSIONS

Body mass index and WC are frequent associated with MS, IR and histological findings (steatohepatitis and fibrosis) in patients with NAFLD.

Authors+Show Affiliations

Curso de Pós Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Bahia, Brazil. raquelrocha2@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16150132

Citation

Rocha, R, et al. "Body Mass Index and Waist Circumference in Non-alcoholic Fatty Liver Disease." Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, vol. 18, no. 5, 2005, pp. 365-70.
Rocha R, Cotrim HP, Carvalho FM, et al. Body mass index and waist circumference in non-alcoholic fatty liver disease. J Hum Nutr Diet. 2005;18(5):365-70.
Rocha, R., Cotrim, H. P., Carvalho, F. M., Siqueira, A. C., Braga, H., & Freitas, L. A. (2005). Body mass index and waist circumference in non-alcoholic fatty liver disease. Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, 18(5), pp. 365-70.
Rocha R, et al. Body Mass Index and Waist Circumference in Non-alcoholic Fatty Liver Disease. J Hum Nutr Diet. 2005;18(5):365-70. PubMed PMID: 16150132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index and waist circumference in non-alcoholic fatty liver disease. AU - Rocha,R, AU - Cotrim,H P, AU - Carvalho,F M, AU - Siqueira,A C, AU - Braga,H, AU - Freitas,L A, PY - 2005/9/10/pubmed PY - 2005/12/28/medline PY - 2005/9/10/entrez SP - 365 EP - 70 JF - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JO - J Hum Nutr Diet VL - 18 IS - 5 N2 - OBJECTIVE: To evaluate the association of anthropometric indexes (body mass index and waist circumference) in patients with non-alcoholic fatty liver disease (NAFLD), and its association with insulin resistance (IR), metabolic syndrome (MS) and histological findings. METHODS: From August 2003 to July 2004 a case series of 81 outpatients with clinic and/or histological diagnosis of NAFLD were selected at the Bahia University Gastro-Hepatology Clinic, Brazil. Liver function tests, lipid profile, glucose and insulin were performed in all patients. Body mass index (BMI) and waist circumference (WC) were determined according to WHO criteria. IR was measured by means of the homeostasis model assessment (HOMA) and IR was considered with HOMA > or =3. MS was defined according to the Adult Treatment Panel III (ATP III). Liver biopsy was performed in 37 cases. RESULTS: Body mass index > or = 30 kg m(-2) (obesity) was found in 39% of the cases and BMI > or = 25-29.9 kg m(-2) (overweight) in 53%. BMI was correlated with IR (r = 0.29; P = 0.02) and WC with ALT (r = 0.02; P = 0.03). Increased WC also was related to IR and to MS. The presence of steatohepatitis with fibrosis on liver biopsy was associated with overweight (68%) and increase of WC (41%). CONCLUSIONS: Body mass index and WC are frequent associated with MS, IR and histological findings (steatohepatitis and fibrosis) in patients with NAFLD. SN - 0952-3871 UR - https://www.unboundmedicine.com/medline/citation/16150132/Body_mass_index_and_waist_circumference_in_non_alcoholic_fatty_liver_disease_ L2 - https://doi.org/10.1111/j.1365-277X.2005.00634.x DB - PRIME DP - Unbound Medicine ER -