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Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.
Psychoneuroendocrinology. 2006 Feb; 31(2):216-25.P

Abstract

Burnout is presumed to be the result of chronic stress, and chronic stress is known to affect the HPA-axis. To date, studies on HPA-axis functioning in burnout have showed inconsistent results. In the present study, a large sample (n=74) of clinically diagnosed burnout individuals, mostly on sick-leave, were included and compared with 35 healthy controls. Salivary cortisol was sampled on 2 days to determine the cortisol awakening response (CAR) and the day-curve. In addition, the dexamethasone suppression test (DST) was applied to assess the feedback efficacy of the HPA-axis. There were no differences observed in the CAR, day-curve or CAR after DST in the burnout group as compared to a healthy control group. Burnout shows overlap in symptoms with chronic fatigue syndrome (CFS) and depression. Therefore, differential changes in HPA-axis functioning that resemble the hypo-functioning of the HPA-axis in CFS, or rather the hyper-functioning of the HPA-axis in depression, might have obscured the findings. However, no effect of fatigue or depressive mood on HPA-axis functioning was found in the burnout group. We concluded that HPA-axis functioning in clinically diagnosed burnout participants as tested in the present study, seems to be normal.

Authors+Show Affiliations

Department of Health Psychology, Utrecht University, P.O. Box 80.140, 3508 TC Utrecht, The Netherlands. p.mommersteeg@fss.uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16150550

Citation

Mommersteeg, Paula M C., et al. "Clinical Burnout Is Not Reflected in the Cortisol Awakening Response, the Day-curve or the Response to a Low-dose Dexamethasone Suppression Test." Psychoneuroendocrinology, vol. 31, no. 2, 2006, pp. 216-25.
Mommersteeg PM, Heijnen CJ, Verbraak MJ, et al. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology. 2006;31(2):216-25.
Mommersteeg, P. M., Heijnen, C. J., Verbraak, M. J., & van Doornen, L. J. (2006). Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology, 31(2), 216-25.
Mommersteeg PM, et al. Clinical Burnout Is Not Reflected in the Cortisol Awakening Response, the Day-curve or the Response to a Low-dose Dexamethasone Suppression Test. Psychoneuroendocrinology. 2006;31(2):216-25. PubMed PMID: 16150550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. AU - Mommersteeg,Paula M C, AU - Heijnen,Cobi J, AU - Verbraak,Marc J P M, AU - van Doornen,Lorenz J P, Y1 - 2005/09/16/ PY - 2005/03/01/received PY - 2005/07/11/revised PY - 2005/07/12/accepted PY - 2005/9/10/pubmed PY - 2006/3/11/medline PY - 2005/9/10/entrez SP - 216 EP - 25 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 2 N2 - Burnout is presumed to be the result of chronic stress, and chronic stress is known to affect the HPA-axis. To date, studies on HPA-axis functioning in burnout have showed inconsistent results. In the present study, a large sample (n=74) of clinically diagnosed burnout individuals, mostly on sick-leave, were included and compared with 35 healthy controls. Salivary cortisol was sampled on 2 days to determine the cortisol awakening response (CAR) and the day-curve. In addition, the dexamethasone suppression test (DST) was applied to assess the feedback efficacy of the HPA-axis. There were no differences observed in the CAR, day-curve or CAR after DST in the burnout group as compared to a healthy control group. Burnout shows overlap in symptoms with chronic fatigue syndrome (CFS) and depression. Therefore, differential changes in HPA-axis functioning that resemble the hypo-functioning of the HPA-axis in CFS, or rather the hyper-functioning of the HPA-axis in depression, might have obscured the findings. However, no effect of fatigue or depressive mood on HPA-axis functioning was found in the burnout group. We concluded that HPA-axis functioning in clinically diagnosed burnout participants as tested in the present study, seems to be normal. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16150550/Clinical_burnout_is_not_reflected_in_the_cortisol_awakening_response_the_day_curve_or_the_response_to_a_low_dose_dexamethasone_suppression_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(05)00175-7 DB - PRIME DP - Unbound Medicine ER -