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[Polymorphic gene markers of lipid metabolism are associated with diabetic nephropathy in patients with type 1 diabetes mellitus].
Genetika. 2005 Jul; 41(7):931-7.G

Abstract

In groups of type 1 diabetes mellitus patients with and without clinical signs of diabetic nephropathy (n = 62 and n = 68, respectively), a search was made for associations between diabetic nephropathy and the polymorphic marker epsilon2/epsilon3/epsilon4 of apolipoprotein E gene (APOE), I/D marker of apolipoprotein B gene (APOB), and Ser447Ter marker of lipoprotein lipase-encoding gene (LPL). The risk of diabetic nephropathy was higher in the carriers of allele epsilon3 and genotype epsilon3/epsilon3 of the polymorphic marker epsilon2/epsilon3/epsilon4 of APOE gene as well as in the carriers of allele 1 and APOB genotype/gene (OR = 2.08 and 2.16; 1.91 and 2.11, respectively). Conversely, the carriers of allele D showed a reduced risk of this complication (OR = 0.52). No significant differences in distribution of alleles and genotypes of the polymorphic marker Ser447Ter of LPL gene were found between the groups. Our results indicate that the genes encoding two major components of lipid metabolism are involved in the development of diabetic nephropathy in patients with type 1 diabetes mellitus.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

16152798

Citation

Iakunina, N Iu, et al. "[Polymorphic Gene Markers of Lipid Metabolism Are Associated With Diabetic Nephropathy in Patients With Type 1 Diabetes Mellitus]." Genetika, vol. 41, no. 7, 2005, pp. 931-7.
Iakunina NIu, Shestakova MV, Voron'ko OE, et al. [Polymorphic gene markers of lipid metabolism are associated with diabetic nephropathy in patients with type 1 diabetes mellitus]. Genetika. 2005;41(7):931-7.
Iakunina, N. I. u., Shestakova, M. V., Voron'ko, O. E., Vikulova, O. K., Sevost'ianov, K. V., Chugunova, L. A., Shamkhalova, M. S. h., Dedov, I. I., & Nosikov, V. V. (2005). [Polymorphic gene markers of lipid metabolism are associated with diabetic nephropathy in patients with type 1 diabetes mellitus]. Genetika, 41(7), 931-7.
Iakunina NIu, et al. [Polymorphic Gene Markers of Lipid Metabolism Are Associated With Diabetic Nephropathy in Patients With Type 1 Diabetes Mellitus]. Genetika. 2005;41(7):931-7. PubMed PMID: 16152798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Polymorphic gene markers of lipid metabolism are associated with diabetic nephropathy in patients with type 1 diabetes mellitus]. AU - Iakunina,N Iu, AU - Shestakova,M V, AU - Voron'ko,O E, AU - Vikulova,O K, AU - Sevost'ianov,K V, AU - Chugunova,L A, AU - Shamkhalova,M Sh, AU - Dedov,I I, AU - Nosikov,V V, PY - 2005/9/13/pubmed PY - 2005/10/19/medline PY - 2005/9/13/entrez SP - 931 EP - 7 JF - Genetika JO - Genetika VL - 41 IS - 7 N2 - In groups of type 1 diabetes mellitus patients with and without clinical signs of diabetic nephropathy (n = 62 and n = 68, respectively), a search was made for associations between diabetic nephropathy and the polymorphic marker epsilon2/epsilon3/epsilon4 of apolipoprotein E gene (APOE), I/D marker of apolipoprotein B gene (APOB), and Ser447Ter marker of lipoprotein lipase-encoding gene (LPL). The risk of diabetic nephropathy was higher in the carriers of allele epsilon3 and genotype epsilon3/epsilon3 of the polymorphic marker epsilon2/epsilon3/epsilon4 of APOE gene as well as in the carriers of allele 1 and APOB genotype/gene (OR = 2.08 and 2.16; 1.91 and 2.11, respectively). Conversely, the carriers of allele D showed a reduced risk of this complication (OR = 0.52). No significant differences in distribution of alleles and genotypes of the polymorphic marker Ser447Ter of LPL gene were found between the groups. Our results indicate that the genes encoding two major components of lipid metabolism are involved in the development of diabetic nephropathy in patients with type 1 diabetes mellitus. SN - 0016-6758 UR - https://www.unboundmedicine.com/medline/citation/16152798/[Polymorphic_gene_markers_of_lipid_metabolism_are_associated_with_diabetic_nephropathy_in_patients_with_type_1_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -