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Elastomeric hydrolyzable porous scaffolds: copolymers of aliphatic polyesters and a polyether-ester.
Biomacromolecules 2005 Sep-Oct; 6(5):2718-25B

Abstract

Porous scaffolds of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) were prepared by a solvent casting, salt particulate leaching technique in which the composites were detached from their mold using a novel methanol swelling procedure. By incorporating DXO segments into polymers containing LLA or CL, an increase in hydrophilicity is achieved, and incorporating soft amorphous domains in the crystalline sections enables tailoring of the mechanical properties. The porosities of the scaffolds ranged from 89.2% to 94.6%, and the pores were shown to be interconnected. The materials were synthesized by bulk copolymerization of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) using stannous 2-ethylhexanoate as catalyst. The copolymers formed varied in structure; poly(DXO-co-CL) is random in its arrangement, whereas poly(DXO-co-LLA) and poly(LLA-co-CL) are more blocky in their structures.

Authors+Show Affiliations

Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16153111

Citation

Odelius, Karin, et al. "Elastomeric Hydrolyzable Porous Scaffolds: Copolymers of Aliphatic Polyesters and a Polyether-ester." Biomacromolecules, vol. 6, no. 5, 2005, pp. 2718-25.
Odelius K, Plikk P, Albertsson AC. Elastomeric hydrolyzable porous scaffolds: copolymers of aliphatic polyesters and a polyether-ester. Biomacromolecules. 2005;6(5):2718-25.
Odelius, K., Plikk, P., & Albertsson, A. C. (2005). Elastomeric hydrolyzable porous scaffolds: copolymers of aliphatic polyesters and a polyether-ester. Biomacromolecules, 6(5), pp. 2718-25.
Odelius K, Plikk P, Albertsson AC. Elastomeric Hydrolyzable Porous Scaffolds: Copolymers of Aliphatic Polyesters and a Polyether-ester. Biomacromolecules. 2005;6(5):2718-25. PubMed PMID: 16153111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elastomeric hydrolyzable porous scaffolds: copolymers of aliphatic polyesters and a polyether-ester. AU - Odelius,Karin, AU - Plikk,Peter, AU - Albertsson,Ann-Christine, PY - 2005/9/13/pubmed PY - 2005/12/29/medline PY - 2005/9/13/entrez SP - 2718 EP - 25 JF - Biomacromolecules JO - Biomacromolecules VL - 6 IS - 5 N2 - Porous scaffolds of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) were prepared by a solvent casting, salt particulate leaching technique in which the composites were detached from their mold using a novel methanol swelling procedure. By incorporating DXO segments into polymers containing LLA or CL, an increase in hydrophilicity is achieved, and incorporating soft amorphous domains in the crystalline sections enables tailoring of the mechanical properties. The porosities of the scaffolds ranged from 89.2% to 94.6%, and the pores were shown to be interconnected. The materials were synthesized by bulk copolymerization of 1,5-dioxepan-2-one (DXO), L-lactide (LLA), and epsilon-caprolactone (CL) using stannous 2-ethylhexanoate as catalyst. The copolymers formed varied in structure; poly(DXO-co-CL) is random in its arrangement, whereas poly(DXO-co-LLA) and poly(LLA-co-CL) are more blocky in their structures. SN - 1525-7797 UR - https://www.unboundmedicine.com/medline/citation/16153111/Elastomeric_hydrolyzable_porous_scaffolds:_copolymers_of_aliphatic_polyesters_and_a_polyether_ester_ L2 - https://dx.doi.org/10.1021/bm050190b DB - PRIME DP - Unbound Medicine ER -