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Towards control of schistosomiasis in sub-Saharan Africa.
J Helminthol. 2005 Sep; 79(3):181-5.JH

Abstract

Approximately 80% of the 200 million people infected with schistosomiasis inhabit sub-Saharan Africa, and the annual mortality is estimated to be 280,000. Praziquantel is the drug of choice in the treatment of schistosomiasis and pregnant women may now be treated. It was agreed at the World Health Assembly in 2001 that at least 75% of school-aged children in high burden areas should be treated for schistosomiasis and soil-transmitted helminth infections by 2010 to reduce morbidity. A grant from the Bill and Melinda Gates Foundation to the Schistosomiasis Control Initiative, Imperial College of Science, Technology and Medicine, London has enabled control programmes to be initiated in Uganda, Tanzania, Zambia, Burkina Faso, Niger and Mali. Additional programmes have recently commenced in Zanzibar with a grant from the Health Foundation to The Natural History Museum, London and in Cameroon. Combination treatment for schistosomiasis, gastrointestinal helminths and filariasis reduces costs of control programmes. The EC Concerted Action Group on 'Praziquantel: its central role in the chemotherapy of schistosome infection' met in Yaoundé Cameroon in 2004 to discuss recent developments in laboratory and field studies. The use of standard operating procedures will enable data on drug action on schistosomes produced in different laboratories to be compared. With the ever increasing use of praziquantel there is a possibility of the development of resistance by schistosomes to the drug, hence the necessity to explore the activities of other compounds. Artemether, unlike praziquantel, is effective against immature schistosomes. The effectiveness of mirazid, an extract of myrrh, is controversial as data from different laboratories are equivocal. It is suggested that an independent body such as the World Health Organization should determine whether mirazid should be used in the treatment of schistosomiasis.

Authors+Show Affiliations

Parasitology Division, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, The Natural History Museum, South Kensington, London SW7 5BD, UK. V.Southgate@nhm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16153310

Citation

Southgate, V R., et al. "Towards Control of Schistosomiasis in sub-Saharan Africa." Journal of Helminthology, vol. 79, no. 3, 2005, pp. 181-5.
Southgate VR, Rollinson D, Tchuem Tchuenté LA, et al. Towards control of schistosomiasis in sub-Saharan Africa. J Helminthol. 2005;79(3):181-5.
Southgate, V. R., Rollinson, D., Tchuem Tchuenté, L. A., & Hagan, P. (2005). Towards control of schistosomiasis in sub-Saharan Africa. Journal of Helminthology, 79(3), 181-5.
Southgate VR, et al. Towards Control of Schistosomiasis in sub-Saharan Africa. J Helminthol. 2005;79(3):181-5. PubMed PMID: 16153310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards control of schistosomiasis in sub-Saharan Africa. AU - Southgate,V R, AU - Rollinson,D, AU - Tchuem Tchuenté,L A, AU - Hagan,P, PY - 2005/9/13/pubmed PY - 2006/2/24/medline PY - 2005/9/13/entrez SP - 181 EP - 5 JF - Journal of helminthology JO - J Helminthol VL - 79 IS - 3 N2 - Approximately 80% of the 200 million people infected with schistosomiasis inhabit sub-Saharan Africa, and the annual mortality is estimated to be 280,000. Praziquantel is the drug of choice in the treatment of schistosomiasis and pregnant women may now be treated. It was agreed at the World Health Assembly in 2001 that at least 75% of school-aged children in high burden areas should be treated for schistosomiasis and soil-transmitted helminth infections by 2010 to reduce morbidity. A grant from the Bill and Melinda Gates Foundation to the Schistosomiasis Control Initiative, Imperial College of Science, Technology and Medicine, London has enabled control programmes to be initiated in Uganda, Tanzania, Zambia, Burkina Faso, Niger and Mali. Additional programmes have recently commenced in Zanzibar with a grant from the Health Foundation to The Natural History Museum, London and in Cameroon. Combination treatment for schistosomiasis, gastrointestinal helminths and filariasis reduces costs of control programmes. The EC Concerted Action Group on 'Praziquantel: its central role in the chemotherapy of schistosome infection' met in Yaoundé Cameroon in 2004 to discuss recent developments in laboratory and field studies. The use of standard operating procedures will enable data on drug action on schistosomes produced in different laboratories to be compared. With the ever increasing use of praziquantel there is a possibility of the development of resistance by schistosomes to the drug, hence the necessity to explore the activities of other compounds. Artemether, unlike praziquantel, is effective against immature schistosomes. The effectiveness of mirazid, an extract of myrrh, is controversial as data from different laboratories are equivocal. It is suggested that an independent body such as the World Health Organization should determine whether mirazid should be used in the treatment of schistosomiasis. SN - 0022-149X UR - https://www.unboundmedicine.com/medline/citation/16153310/Towards_control_of_schistosomiasis_in_sub_Saharan_Africa_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X05000272/type/journal_article DB - PRIME DP - Unbound Medicine ER -