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Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers.
Eur J Med Chem. 2005 Nov; 40(11):1188-92.EJ

Abstract

The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers at 37 degrees C. The effect of concentration and generation of the PAMAM dendrimers has been investigated. Results showed that the solubility of NSAIDs in the PAMAM dendrimer solutions was approximately proportional to dendrimer concentration; the solubility of NSAIDs in higher generation PAMAM solutions was in fact higher that those in lower ones; the order of increased solubility of NSAIDs in PAMAM dendrimers at a constant dendrimer concentration and generation was Naproxen>Ketoprofen>Ibuprofen>Diflunisal. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs.

Authors+Show Affiliations

School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China. yycheng@mail.ustc.edu.cnNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16153746

Citation

Yiyun, Cheng, and Xu Tongwen. "Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-steroidal Anti-inflammatory Drugs in the Presence of Polyamidoamine Dendrimers." European Journal of Medicinal Chemistry, vol. 40, no. 11, 2005, pp. 1188-92.
Yiyun C, Tongwen X. Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers. Eur J Med Chem. 2005;40(11):1188-92.
Yiyun, C., & Tongwen, X. (2005). Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers. European Journal of Medicinal Chemistry, 40(11), 1188-92.
Yiyun C, Tongwen X. Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-steroidal Anti-inflammatory Drugs in the Presence of Polyamidoamine Dendrimers. Eur J Med Chem. 2005;40(11):1188-92. PubMed PMID: 16153746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers. AU - Yiyun,Cheng, AU - Tongwen,Xu, Y1 - 2005/09/08/ PY - 2005/06/02/received PY - 2005/06/14/accepted PY - 2005/9/13/pubmed PY - 2006/2/16/medline PY - 2005/9/13/entrez SP - 1188 EP - 92 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 40 IS - 11 N2 - The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers at 37 degrees C. The effect of concentration and generation of the PAMAM dendrimers has been investigated. Results showed that the solubility of NSAIDs in the PAMAM dendrimer solutions was approximately proportional to dendrimer concentration; the solubility of NSAIDs in higher generation PAMAM solutions was in fact higher that those in lower ones; the order of increased solubility of NSAIDs in PAMAM dendrimers at a constant dendrimer concentration and generation was Naproxen>Ketoprofen>Ibuprofen>Diflunisal. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs. SN - 0223-5234 UR - https://www.unboundmedicine.com/medline/citation/16153746/Dendrimers_as_potential_drug_carriers__Part_I__Solubilization_of_non_steroidal_anti_inflammatory_drugs_in_the_presence_of_polyamidoamine_dendrimers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(05)00170-4 DB - PRIME DP - Unbound Medicine ER -