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Differential activation of dopamine release in the nucleus accumbens core and shell after acute or repeated amphetamine injections: a comparative study in the Roman high- and low-avoidance rat lines.
Neuroscience. 2005; 135(3):987-98.N

Abstract

The selectively bred Roman high- and low-avoidance rats differ in emotionality and responsiveness to the motor effects of acute and repeated psychostimulant administration. These lines also show drastic differences in the neurochemical responses of their mesolimbic dopamine systems to addictive drugs. The nucleus accumbens is critically involved in the locomotor activation produced by psychostimulants and in the augmentation of this effect observed upon repeated drug administration (i.e. behavioral sensitization), although there is not a general consensus as to whether the nucleus accumbens-core or the nucleus accumbens-shell is preferentially involved in such alterations. This study was designed to evaluate the effects of acute amphetamine (0.20 mg/kg, s.c.) on dopamine output in the nucleus accumbens-shell and nucleus accumbens-core of the Roman lines under basal conditions (i.e. naïve rats) and after the repeated administration of amphetamine (1 mg/kg, s.c. x 10 days) or saline. We show that (1) in naïve rats, amphetamine caused a larger increment in dopamine output in the nucleus accumbens-shell vs the nucleus accumbens-core only in the Roman high-avoidance line; (2) repeated amphetamine elicits behavioral sensitization in Roman high-avoidance, but not Roman low-avoidance, rats; (3) in sensitized Roman high-avoidance rats, amphetamine provokes a larger increment in dopamine output in the nucleus accumbens-core, and an attenuated dopaminergic response in the nucleus accumbens-shell, as compared with Roman high-avoidance rats repeatedly treated with saline; and (4) such neurochemical changes are not observed in the mesoaccumbens dopaminergic system of the sensitization-resistant Roman low-avoidance line. We propose that (1) Roman high-avoidance and Roman low-avoidance rats differ in the vulnerability to develop psychostimulant sensitization, (2) the nucleus accumbens-core and nucleus accumbens-shell subserve distinct functional roles in this phenomenon, and (3) comparative studies in the Roman lines may provide insight into the influence of neural substrates and genetic background on the individual vulnerability to addiction.

Authors+Show Affiliations

Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. giorgi@unica.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16154292

Citation

Giorgi, O, et al. "Differential Activation of Dopamine Release in the Nucleus Accumbens Core and Shell After Acute or Repeated Amphetamine Injections: a Comparative Study in the Roman High- and Low-avoidance Rat Lines." Neuroscience, vol. 135, no. 3, 2005, pp. 987-98.
Giorgi O, Piras G, Lecca D, et al. Differential activation of dopamine release in the nucleus accumbens core and shell after acute or repeated amphetamine injections: a comparative study in the Roman high- and low-avoidance rat lines. Neuroscience. 2005;135(3):987-98.
Giorgi, O., Piras, G., Lecca, D., & Corda, M. G. (2005). Differential activation of dopamine release in the nucleus accumbens core and shell after acute or repeated amphetamine injections: a comparative study in the Roman high- and low-avoidance rat lines. Neuroscience, 135(3), 987-98.
Giorgi O, et al. Differential Activation of Dopamine Release in the Nucleus Accumbens Core and Shell After Acute or Repeated Amphetamine Injections: a Comparative Study in the Roman High- and Low-avoidance Rat Lines. Neuroscience. 2005;135(3):987-98. PubMed PMID: 16154292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential activation of dopamine release in the nucleus accumbens core and shell after acute or repeated amphetamine injections: a comparative study in the Roman high- and low-avoidance rat lines. AU - Giorgi,O, AU - Piras,G, AU - Lecca,D, AU - Corda,M G, Y1 - 2005/09/08/ PY - 2005/04/02/received PY - 2005/05/23/revised PY - 2005/06/21/accepted PY - 2005/9/13/pubmed PY - 2005/12/24/medline PY - 2005/9/13/entrez SP - 987 EP - 98 JF - Neuroscience JO - Neuroscience VL - 135 IS - 3 N2 - The selectively bred Roman high- and low-avoidance rats differ in emotionality and responsiveness to the motor effects of acute and repeated psychostimulant administration. These lines also show drastic differences in the neurochemical responses of their mesolimbic dopamine systems to addictive drugs. The nucleus accumbens is critically involved in the locomotor activation produced by psychostimulants and in the augmentation of this effect observed upon repeated drug administration (i.e. behavioral sensitization), although there is not a general consensus as to whether the nucleus accumbens-core or the nucleus accumbens-shell is preferentially involved in such alterations. This study was designed to evaluate the effects of acute amphetamine (0.20 mg/kg, s.c.) on dopamine output in the nucleus accumbens-shell and nucleus accumbens-core of the Roman lines under basal conditions (i.e. naïve rats) and after the repeated administration of amphetamine (1 mg/kg, s.c. x 10 days) or saline. We show that (1) in naïve rats, amphetamine caused a larger increment in dopamine output in the nucleus accumbens-shell vs the nucleus accumbens-core only in the Roman high-avoidance line; (2) repeated amphetamine elicits behavioral sensitization in Roman high-avoidance, but not Roman low-avoidance, rats; (3) in sensitized Roman high-avoidance rats, amphetamine provokes a larger increment in dopamine output in the nucleus accumbens-core, and an attenuated dopaminergic response in the nucleus accumbens-shell, as compared with Roman high-avoidance rats repeatedly treated with saline; and (4) such neurochemical changes are not observed in the mesoaccumbens dopaminergic system of the sensitization-resistant Roman low-avoidance line. We propose that (1) Roman high-avoidance and Roman low-avoidance rats differ in the vulnerability to develop psychostimulant sensitization, (2) the nucleus accumbens-core and nucleus accumbens-shell subserve distinct functional roles in this phenomenon, and (3) comparative studies in the Roman lines may provide insight into the influence of neural substrates and genetic background on the individual vulnerability to addiction. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16154292/Differential_activation_of_dopamine_release_in_the_nucleus_accumbens_core_and_shell_after_acute_or_repeated_amphetamine_injections:_a_comparative_study_in_the_Roman_high__and_low_avoidance_rat_lines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(05)00720-7 DB - PRIME DP - Unbound Medicine ER -