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Is ephedrine infusion more effective at preventing hypotension than traditional prehydration during spinal anaesthesia for caesarean section in African parturients?
Int J Obstet Anesth 2005; 14(4):294-9IJ

Abstract

BACKGROUND

Hypotension following spinal anaesthesia for caesarean section may result in maternal nausea and vomiting and decreased uteroplacental blood flow with possible fetal acidaemia. Numerous methods have been tried to minimise hypotension. In developing countries where resources are limited, this study aimed to compare a standard infusion of ephedrine with traditional prehydration to prevent spinal hypotension.

METHOD

Sixty patients for elective caesarean section were randomly allocated to group 1: 1 L 0.9% saline before spinal block, and group 2: infusion of ephedrine 30 mg in 1 L of 0.9% saline after spinal block, titrated to maternal systolic pressure. Spinal anaesthesia was achieved with 2.5 mL of 0.5% heavy bupivacaine in the L3/L4 interspace.

RESULTS

Systolic pressure decreased 5 min after spinal block. Group 2 had higher mean values of systolic pressure throughout most of the study period than group 1 (P < 0.05). Hypotension occurred in 70% of patients in group 1 and 40% of patients in group 2 (P = 0.037). Severe hypotension occurred in 40% of group 1 and 13.3% of group 2 (P = 0.039). Nausea was the most common side effect of hypotension, occurring in 39.4% of all hypotensive patients. Other complications, including hypertension, tachycardia and bradycardia were similar in the two groups. Neonatal outcome was similar in the two groups and median Apgar scores at one and five minutes were 8.

CONCLUSION

Prophylactic ephedrine given by standard infusion set was more effective than crystalloid prehydration in the prevention of hypotension during spinal anaesthesia for elective caesarean section.

Authors+Show Affiliations

Department of Anaesthesia, College of Medicine, Lagos University Teaching Hospital, Nigeria. ronkedesalu@yahoo.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16154346

Citation

Desalu, I, and O T. Kushimo. "Is Ephedrine Infusion More Effective at Preventing Hypotension Than Traditional Prehydration During Spinal Anaesthesia for Caesarean Section in African Parturients?" International Journal of Obstetric Anesthesia, vol. 14, no. 4, 2005, pp. 294-9.
Desalu I, Kushimo OT. Is ephedrine infusion more effective at preventing hypotension than traditional prehydration during spinal anaesthesia for caesarean section in African parturients? Int J Obstet Anesth. 2005;14(4):294-9.
Desalu, I., & Kushimo, O. T. (2005). Is ephedrine infusion more effective at preventing hypotension than traditional prehydration during spinal anaesthesia for caesarean section in African parturients? International Journal of Obstetric Anesthesia, 14(4), pp. 294-9.
Desalu I, Kushimo OT. Is Ephedrine Infusion More Effective at Preventing Hypotension Than Traditional Prehydration During Spinal Anaesthesia for Caesarean Section in African Parturients. Int J Obstet Anesth. 2005;14(4):294-9. PubMed PMID: 16154346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is ephedrine infusion more effective at preventing hypotension than traditional prehydration during spinal anaesthesia for caesarean section in African parturients? AU - Desalu,I, AU - Kushimo,O T, PY - 2004/09/01/received PY - 2004/12/01/revised PY - 2005/05/01/accepted PY - 2005/9/13/pubmed PY - 2006/2/8/medline PY - 2005/9/13/entrez SP - 294 EP - 9 JF - International journal of obstetric anesthesia JO - Int J Obstet Anesth VL - 14 IS - 4 N2 - BACKGROUND: Hypotension following spinal anaesthesia for caesarean section may result in maternal nausea and vomiting and decreased uteroplacental blood flow with possible fetal acidaemia. Numerous methods have been tried to minimise hypotension. In developing countries where resources are limited, this study aimed to compare a standard infusion of ephedrine with traditional prehydration to prevent spinal hypotension. METHOD: Sixty patients for elective caesarean section were randomly allocated to group 1: 1 L 0.9% saline before spinal block, and group 2: infusion of ephedrine 30 mg in 1 L of 0.9% saline after spinal block, titrated to maternal systolic pressure. Spinal anaesthesia was achieved with 2.5 mL of 0.5% heavy bupivacaine in the L3/L4 interspace. RESULTS: Systolic pressure decreased 5 min after spinal block. Group 2 had higher mean values of systolic pressure throughout most of the study period than group 1 (P < 0.05). Hypotension occurred in 70% of patients in group 1 and 40% of patients in group 2 (P = 0.037). Severe hypotension occurred in 40% of group 1 and 13.3% of group 2 (P = 0.039). Nausea was the most common side effect of hypotension, occurring in 39.4% of all hypotensive patients. Other complications, including hypertension, tachycardia and bradycardia were similar in the two groups. Neonatal outcome was similar in the two groups and median Apgar scores at one and five minutes were 8. CONCLUSION: Prophylactic ephedrine given by standard infusion set was more effective than crystalloid prehydration in the prevention of hypotension during spinal anaesthesia for elective caesarean section. SN - 0959-289X UR - https://www.unboundmedicine.com/medline/citation/16154346/Is_ephedrine_infusion_more_effective_at_preventing_hypotension_than_traditional_prehydration_during_spinal_anaesthesia_for_caesarean_section_in_African_parturients L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-289X(05)00058-0 DB - PRIME DP - Unbound Medicine ER -