Tags

Type your tag names separated by a space and hit enter

Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients.
Metabolism 2005; 54(10):1297-301M

Abstract

The aim of the present study was to investigate the relationship between insulin resistance and tumor necrosis factor alpha (TNF-alpha) as well as soluble TNF receptors (sTNF-R), body mass index (BMI), leptin, adiponectin, and serum lipid profile including triglycerides in nonobese Japanese patients with type 2 diabetes. A total of 88 nonobese Japanese type 2 diabetic patients were studied. The duration of diabetes was 11.0 +/- 0.8 years. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting concentrations of plasma glucose, serum lipids (triglycerides, high-density lipoprotein cholesterol, and total cholesterol), serum leptin, serum adiponectin, serum TNF-alpha, and soluble TNF receptors (sTNF-R1 and sTNF-R2) were also measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment. Insulin resistance was positively correlated with BMI, triglycerides, leptin, and total cholesterol and negatively correlated with adiponectin and high-density lipoprotein cholesterol. In contrast, insulin resistance was not associated with TNF-alpha, nor sTNF-R (sTNF-R1 and sTNF-R2) in our diabetic patients. There was no significant relationship between the 3 measures of TNF-alpha system (TNF-alpha, sTNF-R1, and sTNF-R2) and BMI, serum triglycerides, leptin, or adiponectin in these patients. From these results, it can be concluded that peripheral levels of TNF-alpha system activity are not a major factor responsible for insulin resistance in nonobese Japanese type 2 diabetic patients.

Authors+Show Affiliations

Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka 553-0003, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16154427

Citation

Ohya, Michihiro, et al. "Three Measures of Tumor Necrosis Factor Alpha Activity and Insulin Resistance in Nonobese Japanese Type 2 Diabetic Patients." Metabolism: Clinical and Experimental, vol. 54, no. 10, 2005, pp. 1297-301.
Ohya M, Taniguchi A, Fukushima M, et al. Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients. Metab Clin Exp. 2005;54(10):1297-301.
Ohya, M., Taniguchi, A., Fukushima, M., Nakai, Y., Kawasaki, Y., Nagasaka, S., ... Seino, Y. (2005). Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients. Metabolism: Clinical and Experimental, 54(10), pp. 1297-301.
Ohya M, et al. Three Measures of Tumor Necrosis Factor Alpha Activity and Insulin Resistance in Nonobese Japanese Type 2 Diabetic Patients. Metab Clin Exp. 2005;54(10):1297-301. PubMed PMID: 16154427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients. AU - Ohya,Michihiro, AU - Taniguchi,Ataru, AU - Fukushima,Mitsuo, AU - Nakai,Yoshikatsu, AU - Kawasaki,Yukiko, AU - Nagasaka,Shoichiro, AU - Kuroe,Akira, AU - Taki,Yoshiro, AU - Yoshii,Satoru, AU - Hosokawa,Masaya, AU - Inagaki,Nobuya, AU - Seino,Yutaka, PY - 2004/12/04/received PY - 2005/04/05/accepted PY - 2005/9/13/pubmed PY - 2005/10/28/medline PY - 2005/9/13/entrez SP - 1297 EP - 301 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 54 IS - 10 N2 - The aim of the present study was to investigate the relationship between insulin resistance and tumor necrosis factor alpha (TNF-alpha) as well as soluble TNF receptors (sTNF-R), body mass index (BMI), leptin, adiponectin, and serum lipid profile including triglycerides in nonobese Japanese patients with type 2 diabetes. A total of 88 nonobese Japanese type 2 diabetic patients were studied. The duration of diabetes was 11.0 +/- 0.8 years. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting concentrations of plasma glucose, serum lipids (triglycerides, high-density lipoprotein cholesterol, and total cholesterol), serum leptin, serum adiponectin, serum TNF-alpha, and soluble TNF receptors (sTNF-R1 and sTNF-R2) were also measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment. Insulin resistance was positively correlated with BMI, triglycerides, leptin, and total cholesterol and negatively correlated with adiponectin and high-density lipoprotein cholesterol. In contrast, insulin resistance was not associated with TNF-alpha, nor sTNF-R (sTNF-R1 and sTNF-R2) in our diabetic patients. There was no significant relationship between the 3 measures of TNF-alpha system (TNF-alpha, sTNF-R1, and sTNF-R2) and BMI, serum triglycerides, leptin, or adiponectin in these patients. From these results, it can be concluded that peripheral levels of TNF-alpha system activity are not a major factor responsible for insulin resistance in nonobese Japanese type 2 diabetic patients. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16154427/Three_measures_of_tumor_necrosis_factor_alpha_activity_and_insulin_resistance_in_nonobese_Japanese_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(05)00179-4 DB - PRIME DP - Unbound Medicine ER -