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Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls.
Metabolism. 2005 Oct; 54(10):1398-406.M

Abstract

Low birth weight (LBW) is associated with increased risk of developing type 2 diabetes later in life. Progression from normal to impaired glucose tolerance and overt diabetes may depend, to some extent, on elevation of plasma free fatty acids (FFAs). We undertook this study to elucidate whether a prolonged physiological lipid load could unmask or augment existing metabolic defects in otherwise healthy young LBW subjects. Forty 19-year-old men (LBW [n = 20], controls [normal birth weight, NBW] [n = 20]) without a family history of diabetes underwent an intravenous glucose tolerance test (0.3 g kg(-1)), followed by 2-step hyperinsulinemic-euglycemic clamps (2 x 120 minutes: 10 and 40 mU m(-2) min(-1)) in combination with [3-3H]-glucose and indirect calorimetry. The tests were preceded, in randomized order, by a 24-hour continuous intralipid (20%, 0.4 mg mL(-1) h(-1)) or saline infusion. Estimates of cellular glucose metabolism were obtained and a disposition index calculated. Clamp FFA concentrations were 4- to ten-fold higher during lipid infusion. Both groups experienced a similar decrease in insulin-stimulated glucose disposal in response to lipid infusion (approximately 15%; P < .05), which was mainly accounted for by reduced glucose oxidation (approximately 30%; P < .001). Glycolysis, glucose storage, and glucose production were not significantly altered by lipid infusion. Nevertheless, the LBW group had significantly lower insulin-stimulated glycolysis during lipid infusion (approximately 27%; P < .05) than the NBW group. An appropriate increase in insulin secretion matched the decline in insulin sensitivity in both groups. A 24-hour low-grade intralipid infusion has similar effects on whole-body glucose metabolism and first-phase insulin secretion in 19-year-old, healthy, lean, LBW men with normal glucose tolerance and in NBW controls. We reproduced our previous finding of lower insulin-stimulated glycolysis in this population.

Authors+Show Affiliations

Steno Diabetes Center, DK-2820 Gentofte, Denmark. cbjj@steno.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16154442

Citation

Jensen, Christine B., et al. "Young, Low-birth-weight Men Are Not More Susceptible to the Diabetogenic Effects of a Prolonged Free Fatty Acid Exposure Than Matched Controls." Metabolism: Clinical and Experimental, vol. 54, no. 10, 2005, pp. 1398-406.
Jensen CB, Storgaard H, Holst JJ, et al. Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls. Metabolism. 2005;54(10):1398-406.
Jensen, C. B., Storgaard, H., Holst, J. J., Dela, F., Madsbad, S., & Vaag, A. (2005). Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls. Metabolism: Clinical and Experimental, 54(10), 1398-406.
Jensen CB, et al. Young, Low-birth-weight Men Are Not More Susceptible to the Diabetogenic Effects of a Prolonged Free Fatty Acid Exposure Than Matched Controls. Metabolism. 2005;54(10):1398-406. PubMed PMID: 16154442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls. AU - Jensen,Christine B, AU - Storgaard,Heidi, AU - Holst,Jens Juul, AU - Dela,Flemming, AU - Madsbad,Sten, AU - Vaag,Allan, PY - 2004/09/18/received PY - 2005/05/18/accepted PY - 2005/9/13/pubmed PY - 2005/10/28/medline PY - 2005/9/13/entrez SP - 1398 EP - 406 JF - Metabolism: clinical and experimental JO - Metabolism VL - 54 IS - 10 N2 - Low birth weight (LBW) is associated with increased risk of developing type 2 diabetes later in life. Progression from normal to impaired glucose tolerance and overt diabetes may depend, to some extent, on elevation of plasma free fatty acids (FFAs). We undertook this study to elucidate whether a prolonged physiological lipid load could unmask or augment existing metabolic defects in otherwise healthy young LBW subjects. Forty 19-year-old men (LBW [n = 20], controls [normal birth weight, NBW] [n = 20]) without a family history of diabetes underwent an intravenous glucose tolerance test (0.3 g kg(-1)), followed by 2-step hyperinsulinemic-euglycemic clamps (2 x 120 minutes: 10 and 40 mU m(-2) min(-1)) in combination with [3-3H]-glucose and indirect calorimetry. The tests were preceded, in randomized order, by a 24-hour continuous intralipid (20%, 0.4 mg mL(-1) h(-1)) or saline infusion. Estimates of cellular glucose metabolism were obtained and a disposition index calculated. Clamp FFA concentrations were 4- to ten-fold higher during lipid infusion. Both groups experienced a similar decrease in insulin-stimulated glucose disposal in response to lipid infusion (approximately 15%; P < .05), which was mainly accounted for by reduced glucose oxidation (approximately 30%; P < .001). Glycolysis, glucose storage, and glucose production were not significantly altered by lipid infusion. Nevertheless, the LBW group had significantly lower insulin-stimulated glycolysis during lipid infusion (approximately 27%; P < .05) than the NBW group. An appropriate increase in insulin secretion matched the decline in insulin sensitivity in both groups. A 24-hour low-grade intralipid infusion has similar effects on whole-body glucose metabolism and first-phase insulin secretion in 19-year-old, healthy, lean, LBW men with normal glucose tolerance and in NBW controls. We reproduced our previous finding of lower insulin-stimulated glycolysis in this population. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16154442/Young_low_birth_weight_men_are_not_more_susceptible_to_the_diabetogenic_effects_of_a_prolonged_free_fatty_acid_exposure_than_matched_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(05)00213-1 DB - PRIME DP - Unbound Medicine ER -