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Effects of alternations (10 days) of high-fat with normal diet on liver lipid infiltration, fat gain, and plasma metabolic profile in rats.

Abstract

The purpose of the present study was to test the hypothesis that short-term alternations of high-fat with normal chow feeding result in higher fat accumulation in liver than continuous intake of the same high-fat diet. Male Sprague-Dawley rats (7 weeks of age) were divided into 3 groups according to diet composition: standard chow (SD; 12,5% kcal as fat), high-fat (HF; 42% kcal as fat), and food cycles (FC) consisting of 10-day alternations between HF and SD diets beginning with the high-fat diet. Rats in each of these 3 groups were sacrificed after 10, 30, and 50 days (n = 10 rats/sub-groups). Energy intake, body weight, liver and muscle relative weights were not significantly (P > 0.05) different between FC- and HF-fed rats. Using the total energy intake for the 50-day period, it was calculated that approximately 30% less calories as fat was ingested in the FC- compared to the HF-fed rats. In spite of this, liver lipid infiltration as well as fat accretion in abdominal adipose tissues were increased (P < 0.01) similarly in FC- and HF-fed rats. Plasma FFA and insulin levels depicted strong tendencies (P < 0.07) to be higher in FC- than in continuous HF-fed rats at the end of the 50-day period. These results indicate that, despite a 30% reduction in ingested lipids, alternations of HF with normal chow diet compared to the continuous hyperlipidic diet caused the same level of infiltration of lipids in the liver and in the abdominal adipose tissues and, to a certain extent, may even result in a larger deterioration of the metabolic profile.

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  • Authors+Show Affiliations

    ,

    Département de kinésiologie, Université de Montréal, C.P. 6128, Succ. centre-ville, Montréal (Québec), Canada, H3C 3J7. jean-marc.lavoie@umontreal.ca

    , ,

    Source

    Physiology & behavior 86:4 2005 Nov 15 pg 442-8

    MeSH

    Adipose Tissue
    Animals
    Dietary Fats
    Energy Metabolism
    Fatty Acids, Nonesterified
    Fatty Liver
    Insulin
    Liver
    Male
    Obesity
    Rats
    Rats, Sprague-Dawley
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16154606

    Citation

    Lavoie, Jean-Marc, et al. "Effects of Alternations (10 Days) of High-fat With Normal Diet On Liver Lipid Infiltration, Fat Gain, and Plasma Metabolic Profile in Rats." Physiology & Behavior, vol. 86, no. 4, 2005, pp. 442-8.
    Lavoie JM, Yasari S, Abdennadher M, et al. Effects of alternations (10 days) of high-fat with normal diet on liver lipid infiltration, fat gain, and plasma metabolic profile in rats. Physiol Behav. 2005;86(4):442-8.
    Lavoie, J. M., Yasari, S., Abdennadher, M., & Paquette, A. (2005). Effects of alternations (10 days) of high-fat with normal diet on liver lipid infiltration, fat gain, and plasma metabolic profile in rats. Physiology & Behavior, 86(4), pp. 442-8.
    Lavoie JM, et al. Effects of Alternations (10 Days) of High-fat With Normal Diet On Liver Lipid Infiltration, Fat Gain, and Plasma Metabolic Profile in Rats. Physiol Behav. 2005 Nov 15;86(4):442-8. PubMed PMID: 16154606.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of alternations (10 days) of high-fat with normal diet on liver lipid infiltration, fat gain, and plasma metabolic profile in rats. AU - Lavoie,Jean-Marc, AU - Yasari,Siham, AU - Abdennadher,Mahdi, AU - Paquette,Amélie, Y1 - 2005/09/12/ PY - 2005/04/05/received PY - 2005/07/21/revised PY - 2005/07/22/accepted PY - 2005/9/13/pubmed PY - 2006/1/18/medline PY - 2005/9/13/entrez SP - 442 EP - 8 JF - Physiology & behavior JO - Physiol. Behav. VL - 86 IS - 4 N2 - The purpose of the present study was to test the hypothesis that short-term alternations of high-fat with normal chow feeding result in higher fat accumulation in liver than continuous intake of the same high-fat diet. Male Sprague-Dawley rats (7 weeks of age) were divided into 3 groups according to diet composition: standard chow (SD; 12,5% kcal as fat), high-fat (HF; 42% kcal as fat), and food cycles (FC) consisting of 10-day alternations between HF and SD diets beginning with the high-fat diet. Rats in each of these 3 groups were sacrificed after 10, 30, and 50 days (n = 10 rats/sub-groups). Energy intake, body weight, liver and muscle relative weights were not significantly (P > 0.05) different between FC- and HF-fed rats. Using the total energy intake for the 50-day period, it was calculated that approximately 30% less calories as fat was ingested in the FC- compared to the HF-fed rats. In spite of this, liver lipid infiltration as well as fat accretion in abdominal adipose tissues were increased (P < 0.01) similarly in FC- and HF-fed rats. Plasma FFA and insulin levels depicted strong tendencies (P < 0.07) to be higher in FC- than in continuous HF-fed rats at the end of the 50-day period. These results indicate that, despite a 30% reduction in ingested lipids, alternations of HF with normal chow diet compared to the continuous hyperlipidic diet caused the same level of infiltration of lipids in the liver and in the abdominal adipose tissues and, to a certain extent, may even result in a larger deterioration of the metabolic profile. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16154606/Effects_of_alternations__10_days__of_high_fat_with_normal_diet_on_liver_lipid_infiltration_fat_gain_and_plasma_metabolic_profile_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(05)00282-9 DB - PRIME DP - Unbound Medicine ER -