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Glycated albumin is low in obese, non-diabetic children.
Diabetes Res Clin Pract. 2006 Mar; 71(3):334-8.DR

Abstract

The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any differences in these indices. GA, HbA1c, casual PG and casual IRI in obese children (n = 209) were compared to those of non-obese children (n = 1060) in Ina town, Saitama Prefecture, in 2002-2003. In obese children, the levels of HbA1c, PG and IRI were statistically higher when compared to those of non-obese children. In contrast, the median and intra-quartile range (IQR) of GA of obese children (13.6%: 12.6-14.7) was statistically lower when compared to that of non-obese children (14.3%: 13.5-15.4, p < 0.001). The low GA (%) in obese children is mainly due to the low absolute value of GA (g/dl) rather than a higher albumin value (g/dl). This is the first report to reveal that GA levels are low in obese, non-diabetic children. Additional data collection and an experimental approach are necessary to reveal the reasons behind lower GA levels in obese children.

Authors+Show Affiliations

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan. rimei@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16154660

Citation

Nishimura, Rimei, et al. "Glycated Albumin Is Low in Obese, Non-diabetic Children." Diabetes Research and Clinical Practice, vol. 71, no. 3, 2006, pp. 334-8.
Nishimura R, Kanda A, Sano H, et al. Glycated albumin is low in obese, non-diabetic children. Diabetes Res Clin Pract. 2006;71(3):334-8.
Nishimura, R., Kanda, A., Sano, H., Matsudaira, T., Miyashita, Y., Morimoto, A., Shirasawa, T., Kawaguchi, T., & Tajima, N. (2006). Glycated albumin is low in obese, non-diabetic children. Diabetes Research and Clinical Practice, 71(3), 334-8.
Nishimura R, et al. Glycated Albumin Is Low in Obese, Non-diabetic Children. Diabetes Res Clin Pract. 2006;71(3):334-8. PubMed PMID: 16154660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycated albumin is low in obese, non-diabetic children. AU - Nishimura,Rimei, AU - Kanda,Akira, AU - Sano,Hironari, AU - Matsudaira,Toru, AU - Miyashita,Yumi, AU - Morimoto,Aya, AU - Shirasawa,Takako, AU - Kawaguchi,Takeshi, AU - Tajima,Naoko, Y1 - 2005/09/09/ PY - 2005/04/01/received PY - 2005/06/06/revised PY - 2005/07/28/accepted PY - 2005/9/13/pubmed PY - 2006/7/20/medline PY - 2005/9/13/entrez SP - 334 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 71 IS - 3 N2 - The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any differences in these indices. GA, HbA1c, casual PG and casual IRI in obese children (n = 209) were compared to those of non-obese children (n = 1060) in Ina town, Saitama Prefecture, in 2002-2003. In obese children, the levels of HbA1c, PG and IRI were statistically higher when compared to those of non-obese children. In contrast, the median and intra-quartile range (IQR) of GA of obese children (13.6%: 12.6-14.7) was statistically lower when compared to that of non-obese children (14.3%: 13.5-15.4, p < 0.001). The low GA (%) in obese children is mainly due to the low absolute value of GA (g/dl) rather than a higher albumin value (g/dl). This is the first report to reveal that GA levels are low in obese, non-diabetic children. Additional data collection and an experimental approach are necessary to reveal the reasons behind lower GA levels in obese children. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16154660/Glycated_albumin_is_low_in_obese_non_diabetic_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(05)00302-5 DB - PRIME DP - Unbound Medicine ER -