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Altered cortisol awakening response in posttraumatic stress disorder.
Psychoneuroendocrinology. 2006 Feb; 31(2):209-15.P

Abstract

An altered function of the hypothalamic-pituitary-adrenal axis is assumed to be characteristic for Posttraumatic Stress Disorder (PTSD), although there is inconsistent empirical evidence. Only few studies examined the awakening cortisol response and a daytime profile in PTSD. Salivary cortisol levels were measured at seven intervals from awakening until 8 PM in trauma-exposed subjects with (N=29) and without PTSD (N=19) and in 15 non-exposed controls. While the three groups did not differ with respect to their first cortisol level immediately after awakening, the expected cortisol increase to awakening 15-60 min later was significantly lower in PTSD patients compared to non-PTSD subjects and healthy controls. This effect remained stable when trauma-exposed subjects with comorbid major depression were excluded from the analysis. A significant negative correlation between the overall cortisol secretion (AUC(G)) and overall PTSD symptomatology and hyper-arousal symptoms was found. The findings are discussed in light of the hypothesis of a counterregulation of hyper-arousal symptoms and chronic stress in PTSD.

Authors+Show Affiliations

Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany. wessa@zi-mannheim.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16154709

Citation

Wessa, Michèle, et al. "Altered Cortisol Awakening Response in Posttraumatic Stress Disorder." Psychoneuroendocrinology, vol. 31, no. 2, 2006, pp. 209-15.
Wessa M, Rohleder N, Kirschbaum C, et al. Altered cortisol awakening response in posttraumatic stress disorder. Psychoneuroendocrinology. 2006;31(2):209-15.
Wessa, M., Rohleder, N., Kirschbaum, C., & Flor, H. (2006). Altered cortisol awakening response in posttraumatic stress disorder. Psychoneuroendocrinology, 31(2), 209-15.
Wessa M, et al. Altered Cortisol Awakening Response in Posttraumatic Stress Disorder. Psychoneuroendocrinology. 2006;31(2):209-15. PubMed PMID: 16154709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered cortisol awakening response in posttraumatic stress disorder. AU - Wessa,Michèle, AU - Rohleder,Nicolas, AU - Kirschbaum,Clemens, AU - Flor,Herta, Y1 - 2005/09/09/ PY - 2004/10/14/received PY - 2005/05/02/revised PY - 2005/06/14/accepted PY - 2005/9/13/pubmed PY - 2006/3/11/medline PY - 2005/9/13/entrez SP - 209 EP - 15 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 2 N2 - An altered function of the hypothalamic-pituitary-adrenal axis is assumed to be characteristic for Posttraumatic Stress Disorder (PTSD), although there is inconsistent empirical evidence. Only few studies examined the awakening cortisol response and a daytime profile in PTSD. Salivary cortisol levels were measured at seven intervals from awakening until 8 PM in trauma-exposed subjects with (N=29) and without PTSD (N=19) and in 15 non-exposed controls. While the three groups did not differ with respect to their first cortisol level immediately after awakening, the expected cortisol increase to awakening 15-60 min later was significantly lower in PTSD patients compared to non-PTSD subjects and healthy controls. This effect remained stable when trauma-exposed subjects with comorbid major depression were excluded from the analysis. A significant negative correlation between the overall cortisol secretion (AUC(G)) and overall PTSD symptomatology and hyper-arousal symptoms was found. The findings are discussed in light of the hypothesis of a counterregulation of hyper-arousal symptoms and chronic stress in PTSD. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16154709/Altered_cortisol_awakening_response_in_posttraumatic_stress_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(05)00170-8 DB - PRIME DP - Unbound Medicine ER -